Journal ArticleDOI
A predictive model for massive transfusion in combat casualty patients
Daniel F. McLaughlin,Sarah E. Niles,Jose Salinas,Jeremy G. Perkins,E. Darrin Cox,Charles E. Wade,John B. Holcomb +6 more
TLDR
Independent predictors for MT were identified in a cohort of severely injured patients requiring transfusions and patients requiring a MT can be identified with variables commonly obtained upon hospital admission.Abstract:
Background:Massive transfusion (MT) is associated with increased morbidity and mortality in severely injured patients. Early and aggressive use of blood products in these patients may correct coagulopathy, control bleeding, and improve outcomes. However, rapid identification of patients at risk forread more
Citations
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Journal ArticleDOI
Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients
John B. Holcomb,Charles E. Wade,Joel E. Michalek,Gary B. Chisholm,Lee Ann Zarzabal,Martin A. Schreiber,Ernest A. Gonzalez,Gregory J. Pomper,Jeremy G. Perkins,Phillip C. Spinella,Kari L. Williams,Myung S. Park +11 more
TL;DR: The combination of high plasma and high platelet to RBC ratios were associated with decreased truncal hemorrhage, increased 6-hour, 24 hours, and 30-day survival, and increased intensive care unit, ventilator, and hospital-free days, with no change in multiple organ failure deaths.
Journal ArticleDOI
The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: Comparative effectiveness of a time-varying treatment with competing risks
John B. Holcomb,Deborah J. del Junco,Erin E. Fox,Charles E. Wade,Mitchell J. Cohen,Martin A. Schreiber,Louis H. Alarcon,Yu Bai,Karen J. Brasel,Eileen M. Bulger,Bryan A. Cotton,Nena Matijevic,Peter Muskat,John G. Myers,Herb A. Phelan,Christopher E. White,Jiajie Zhang,Mohammad H. Rahbar +17 more
TL;DR: Higher plasma and platelet ratios early in resuscitation were associated with decreased mortality in patients who received transfusions of at least 3 units of blood products during the first 24 hours after admission, and among survivors at 24 hours, the subsequent risk of death by day 30 was not associated with plasma or Platelet ratios.
Journal ArticleDOI
Early Prediction of Massive Transfusion in Trauma: Simple as ABC (Assessment of Blood Consumption)?
Timothy C. Nunez,Igor V. Voskresensky,Lesly A. Dossett,Ricky Shinall,William D. Dutton,Bryan A. Cotton,Bryan A. Cotton +6 more
TL;DR: The ABC score, which uses nonlaboratory, nonweighted parameters, is a simple and accurate in identifying patients who will require MT as compared with those previously published scores.
Journal ArticleDOI
Warm fresh whole blood is independently associated with improved survival for patients with combat-related traumatic injuries.
Philip C. Spinella,Jeremy G. Perkins,Jeremy G. Perkins,Kurt W. Grathwohl,Alec C. Beekley,John B. Holcomb +5 more
TL;DR: In patients with trauma with hemorrhagic shock, resuscitation strategies that include W FWB may improve 30-day survival, and may be a result of less anticoagulants and additives with WFWB use in this population.
Journal ArticleDOI
Resuscitation and transfusion principles for traumatic hemorrhagic shock.
TL;DR: Recently described mechanisms that contribute to traumatic coagulopathy, which include increased anti-coagulation factors and hyperfibrinolysis are discussed, suggest that these concepts may significantly decrease mortality in massively transfused trauma patients.
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Damage control resuscitation: Directly addressing the early coagulopathy of trauma
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