Journal ArticleDOI
A review of botanical characteristics, phytochemistry, clinical relevance in efficacy and safety of Lycium barbarum fruit (Goji)
TLDR
A review of chemical constituents and efficacies with safety of L. barbarum can be found in this article, where a new direction for research and current regulatory situation of the chemical constituents are discussed.About:
This article is published in Food Research International.The article was published on 2011-08-01. It has received 442 citations till now. The article focuses on the topics: Goji berry.read more
Citations
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Journal ArticleDOI
Biological activities and potential health benefit effects of polysaccharides isolated from Lycium barbarum L.
TL;DR: The purpose of the present review is to summarize previous and current references regarding biological activities as well as potential health benefits of L. barbarum polysaccharides.
Journal ArticleDOI
Characterization and hypoglycemic effect of a polysaccharide extracted from the fruit of Lycium barbarum L.
TL;DR: In vitro and in vivo hypoglycemic experiments showed that LBP-s-1 had significanthypoglycemic effects and insulin-sensitizing activity through increasing glucose metabolism and insulin secretion and promoting pancreatic β cell proliferation.
Journal ArticleDOI
Goji berry fruit (Lycium spp.): antioxidant compound fingerprint and bioactivity evaluation
Dario Donno,Gabriele Loris Beccaro,Maria Gabriella Mellano,Alessandro Kim Cerutti,Giancarlo Bounous +4 more
TL;DR: Goji berry was identified as a rich source of antioxidant compounds, with health-promoting properties comparable with other common fruit species, and may be useful to better understand the nutraceutical traits of this species recently considered as functional food.
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An evidence-based update on the pharmacological activities and possible molecular targets of Lycium barbarum polysaccharides.
Jiang Cheng,Zhi Wei Zhou,Hui Ping Sheng,Lan Jie He,Xue Wen Fan,Zhi Xu He,Tao Sun,Xueji Zhang,Ruan Jin Zhao,Ling Gu,Chuanhai Cao,Shu-Feng Zhou +11 more
TL;DR: There is increasing evidence from preclinical and clinical studies supporting the therapeutic and health-promoting effects of LBPs, but further mechanistic and clinical Studies are warranted to establish the dose–response relationships and safety profiles of LBP.
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Lycium barbarum polysaccharides: Extraction, purification, structural characterisation and evidence about hypoglycaemic and hypolipidaemic effects. A review.
Alessandra Masci,Simone Carradori,Maria Antonietta Casadei,Patrizia Paolicelli,Stefania Petralito,Rino Ragno,Stefania Cesa +6 more
TL;DR: The evidence suggests that these purified components of the Goji berry may be potentially useful as adjuvants in the treatment of diabetes and its correlated illnesses.
References
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Journal ArticleDOI
Protective effect of Lycium barbarum polysaccharide 4 on kidneys in streptozotocin-induced diabetic rats.
TL;DR: The decreased activation of ERK1/2 in mesangial cells, through the involvement of PKC, could explain the protective mechanism in kidneys of diabetic rats treated with LBP-4.
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Evaluation of hypoglycemic activity of the polysaccharides extracted from lycium barbarum
TL;DR: The data demonstrated LBP at the dose of 40 mg/kg bw exhibited the better effect, and LBP significantly increased body weight.
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Antioxidants rescue photoreceptors in rd1 mice: Relationship with thiol metabolism
María Miranda,Emma Arnal,Satpal Ahuja,Raquel Alvarez-Nölting,Rosa López-Pedrajas,Per Ekström,Francisco Bosch-Morell,Theo van Veen,Theo van Veen,Francisco J. Romero +9 more
TL;DR: Thiol contents and thiol-dependent peroxide metabolism seem to be directly related to the survival of photoreceptors in rd1 mouse retina.
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Lycium barbarum inhibits growth of estrogen receptor positive human breast cancer cells by favorably altering estradiol metabolism.
TL;DR: The ER + MCF-7 model examined growth inhibitory effects of the medicinal herb Lycium barbarum and identified mechanistic leads for its efficacy and retained their mitogenic and metabolic response to E 2 and LB downregulates E 2 -stimulated growth via the formation of antiproliferative 2-OHE 1 and accelerated conversion of mitogenic 16α -OHE1 to antimitogenic E 3 .
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[Effects of Lycium barbarum polysaccharide on tumor microenvironment T-lymphocyte subsets and dendritic cells in H22-bearing mice].
TL;DR: LBP has anti-tumor effect probably by increasing the numbers of CD4(+) and CD8(+) T cells in TIL to relieve the immunosuppression and enhance the anti-Tumor function of the immune system.