Journal ArticleDOI
A solvent-free Jacobs–Gould reaction
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This article is published in Green Chemistry.The article was published on 2000-01-01. It has received 14 citations till now. The article focuses on the topics: Dry media reaction & Stepwise reaction.read more
Citations
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Microwave assisted organic synthesis-a review
Journal ArticleDOI
More sustainable approaches for the synthesis of N-based heterocycles.
TL;DR: This research presents a novel and scalable approach to nanosciences called “Smart Nanotechnology” that combines “smart chip” technology with traditional “nanofiltration” techniques.
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Accounting for clean, fast and high yielding reactions under microwave conditions
TL;DR: The authors showed that rigid adherence to the sixth principle of green chemistry relating to the use of ambient temperature and pressure may not always afford optimal results, and that microwave heated reactions proceed faster and more cleanly than their conventional heated counterparts are valid only when comparably rapid heating and cooling cannot be obtained by conventional heating.
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Highly efficient thermal cyclization reactions of alkylidene esters in continuous flow to give aromatic/heteroaromatic derivatives
László Lengyel,Tibor Zs. Nagy,Gellért Sipos,Richard A. L. Jones,György Dormán,László Ürge,Ferenc Darvas +6 more
TL;DR: In this article, the Gould-Jacobs and Conrad-Limpach types were performed in a designed continuous flow reactor system at temperatures in the range of 300-360°C and under high pressure conditions (100-160 bar) with very short residence times (0.45-4.5min) in tetrahydrofuran as a low-boiling point solvent.
References
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Journal ArticleDOI
The Synthesis of Certain Substituted Quinolines and 5,6-Benzoquinolines
R. Gordon Gould,Walter A. Jacobs +1 more
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Cyclization of 2-aminopyridine derivatives; substituted ethyl 2-pyridylamino-methylenemalonates.
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Recent advances in the synthesis of antibacterial quinolones
Stanislav Radl,Daniel Bouzard +1 more
TL;DR: In this article, the main synthetic approaches used for the construction of antibacterial quinolones, including aza analogs (naphthyridones, cinnolones) and condensed polycyclic analogs, with an emphasis on the more versatile methods which are potentially useful in other fields of heterocyclic chemistry.
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Quinolone antibacterial agents. Synthesis and structure-activity relationships of a series of amino acid prodrugs of racemic and chiral 7-(3-amino-1-pyrrolidinyl)quinolones. Highly soluble quinolone prodrugs with in vivo pseudomonas activity.
Joseph P. Sanchez,John M. Domagala,Carl L. Heifetz,Stephen R. Priebe,Josephine A. Sesnie,Ashok K. Trehan +5 more
TL;DR: The amino acid derivatives showed a 3-70 times improved solubility when compared to the parent compounds, and the amino acid analogues were less active in vitro, but had equal or increased efficacy in vivo.
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A novel synthesis of the pyrazolo[1,5-a]quinoline ring system. New N1-C2 bridged DNA gyrase inhibitors via a novel tandem 1,4-conjugate addition-Michael [3+2] annulation process
TL;DR: A novel tandem 1,4-conjugate addition-intramolecular Michael addition [3+2] annulation process for synthesis of the pyrazolo[1,5-a]quinoline ring system is described.