Journal ArticleDOI
A Theoretical Study of Epidural Electrical Stimulation of the Spinal Cord - Part II: Effects on Long Myelinated Fibers
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TLDR
A lumped network model of the myelinated nerve axon is used to predict stimulation thresholds for afferent fiber pathways in the dorsal columns and dorsal roots, and Comparisons are made to other possible targets of stimulation.Abstract:
This second paper, of two, draws upon earlier finite element solutions for electrical fields generated within the spinal cord by epidural electrodes. Given those fields, a lumped network model of the myelinated nerve axon is used to predict stimulation thresholds for afferent fiber pathways in the dorsal columns and dorsal roots. Threshold predictions for dorsal column fibers of 5 and 10 , im diameters correspond closely with sensory thresholds reported experimentally. Descending fibers in the lateral corticospinal tracts are also considered. Comparisons are made to other possible targets of stimulation, and the theoretical indications are discussed in the context of clinical findings.read more
Citations
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Patent
Multichannel apparatus for epidural spinal cord stimulation
TL;DR: In this article, a multi-channel transverse epidural spinal cord stimulation using a multichannel pulse generator driving a plurality of electrodes mounted near the distal end of a lead is described.
Journal ArticleDOI
A Computational Model for Epidural Electrical Stimulation of Spinal Sensorimotor Circuits
Marco Capogrosso,Marco Capogrosso,Nikolaus Wenger,Stanisa Raspopovic,Stanisa Raspopovic,Pavel Musienko,Janine Beauparlant,Lorenzo Bassi Luciani,Grégoire Courtine,Silvestro Micera,Silvestro Micera +10 more
TL;DR: A computational model and in vivo experiments were designed and performed to investigate the type of fibers, neurons, and circuits recruited in response to EES to provide a mechanistic framework for the design of spinal neuroprosthetic systems to improve standing and walking after neurological disorders.
Journal ArticleDOI
Stepping-like movements in humans with complete spinal cord injury induced by epidural stimulation of the lumbar cord: electromyographic study of compound muscle action potentials
Karen Minassian,B. Jilge,Frank Rattay,M. M. Pinter,Heinrich Binder,F. Gerstenbrand,Milan R. Dimitrijevic +6 more
TL;DR: It is proposed that repeated volleys delivered to the lumbar cord via the posterior roots can effectively modify the central state of spinal circuits by temporarily combining them into functional units generating integrated motor behavior of sustained extension and rhythmic flexion/extension movements.
Journal ArticleDOI
A nerve cuff technique for selective excitation of peripheral nerve trunk regions
TL;DR: Modeling and experimentation both suggest that longitudinally aligned tripolardot electrodes on the surface of a nerve trunk, and bounded by a layer of insulation (such as a nerve cuff), will restrict excitation to superficial nerve trunk regions more successfully than will monopolar dot electrodes.
Journal ArticleDOI
Excitation of dorsal root fibers in spinal cord stimulation: a theoretical study
TL;DR: The results of this modeling study predict that, besides the well known influence of fiber diameter, the curvature of the dorsal root fiber and the angle between these fibers and the spinal cord axis are a major influence on their threshold values.
References
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Journal ArticleDOI
Which elements are excited in electrical stimulation of mammalian central nervous system: a review
TL;DR: There are data on the amount of current necessary to stimulate a myelinated fiber or cell body and/or its axon a given distance away from a monopolar electrode over the entire range of practical interest for intracranial stimulation.
Journal ArticleDOI
Electrical inhibition of pain by stimulation of the dorsal columns: preliminary clinical report.
TL;DR: Electrical Inhibition of Pain by Stimulation of the Dorsal Columns: Preliminary Clinical Report
Journal ArticleDOI
Analysis of a Model for Excitation of Myelinated Nerve
TL;DR: It is shown that even when the stimulus is a constant-current pulse, the membrane current at the nodes varies considerably with time, and the strength-duration curve calculated from the model is consistent with previously published experimental data.
Journal ArticleDOI
Temporary Abolition of Pain in Man
Patrick D. Wall,William H. Sweet +1 more
TL;DR: In eight patients with intense chronic cutaneous pain, sensory nerves or roots, square-wave 0.1-millisecond pulses at 100 cycles per second were applied and the voltage was raised until the patient reported tingling in the area, and pressure on previously sensitive areas failed to evoke pain.