Abnormal pulmonary function and imaging studies in critical COVID-19 survivors at 100 days after the onset of symptoms.
Maki Miwa,Mikio Nakajima,Richard H Kaszynski,Shoichiro Hamada,Hitoshi Ando,Tomotsugu Nakano,Masamitsu Shirokawa,Hideaki Goto +7 more
TLDR
In this paper, the authors investigated the pulmonary function and computed tomography (CT) findings of critical COVID-19 patients approximately 100 days after symptom onset and found that the extent of the residual CT findings might be associated with the degree of abnormal pulmonary function.Abstract:
Background The long-term repercussions of critical COVID-19 on pulmonary function and imaging studies remains unexplored. In this study, we investigated the pulmonary function and computed tomography (CT) findings of critical COVID-19 patients approximately 100 days after symptom onset. Methods We retrospectively extracted data on critical COVID-19 patients who received invasive mechanical ventilation during hospitalization from April to December 2020 and evaluated their pulmonary function, residual respiratory symptoms and radiographic abnormalities on CT. Results We extracted 17 patients whose median age was 63 (interquartile range [IQR], 59–67) years. The median lengths of hospitalization and mechanical ventilation were 23 (IQR, 18–38) and 9 (IQR, 6–13) days, respectively. At 100 days after symptom onset, the following pulmonary function abnormalities were noted in 8 (47%) patients: a diffusion capacity of the lung for carbon monoxide (%DLCO) of Conclusions Over 90% of the critical COVID-19 patients who underwent invasive mechanical ventilation continued presenting with abnormal imaging studies and 47% of the patients presented with abnormal pulmonary function 100 days after symptom onset. The extent of the residual CT findings might be associated with the degree of abnormal pulmonary function in critical COVID-19 survivors.read more
Citations
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Parenchymal lung abnormalities following hospitalisation for COVID-19 and viral pneumonitis: a systematic review and meta-analysis
Laura Fabbri,Samuel M Moss,Fasihul Khan,Wen-Juan Chi,Junfeng Xie,Karen A. Robinson,Alan R. Smyth,Gisli Jenkins,Iain A. Stewart +8 more
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Post-COVID-19 Syndrome
TL;DR: An integrative review was conducted using Whittemore and Knafl's methodology for literature published through August 30, 2021, using combinations of the following key words: post-COVID-19 syndrome, post-SARS-CoV-2, long COVID- 19, and pathophysiology of post-CoVID19 syndrome as discussed by the authors .
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Post-viral parenchymal lung disease of COVID-19 and viral pneumonitis: A systematic review and meta-analysis.
Laura Fabbri,Laura Fabbri,Laura Fabbri,Samuel Moss,Samuel Moss,Fasihul Khan,Fasihul Khan,Wenjie Chi,Jun Xia,Karen A. Robinson,Alan R. Smyth,Alan R. Smyth,Gisli Jenkins,Gisli Jenkins,Gisli Jenkins,Iain A. Stewart,Iain A. Stewart,Iain A. Stewart +17 more
TL;DR: Although estimates of prevalence are likely limited by differences in case mix and initial severity, a substantial proportion of radiological and functional sequelae are observed following viral pneumonitis, including COVID-19, which highlights the importance of vigilant radiology and functional follow up.
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Role of antifibrotic drugs in the management of post-COVID-19 interstitial lung disease: A review of literature and report from an expert working group
Sundeep Salvi,Deesha Ghorpade,Sahajal Dhoori,Raja Dhar,Harjit Dumra,Prashant N. Chhajed,Parathasarathi Bhattacharya,Sujeet Rajan,Deepak Talwar,Devasahayam J. Christopher,Murali Mohan,Zarir F Udwadia +11 more
TL;DR: Almost one-third of the survivors of SARS have been shown to have significant pulmonary fibrosis, and it seems likely that lung fibrosis may be a common long-term consequence of COVID-19 pneumonia.
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Pulmonary function test and computed tomography features during follow-up after SARS, MERS and COVID-19: a systematic review and meta-analysis
TL;DR: In this paper , the longitudinal pulmonary function test (PFT) and computed tomography (CT) features of patients recovering from SARS, MERS and COVID-19 infection were performed.
References
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TL;DR: In this article, the authors describe the long-term health consequences of patients with COVID-19 who have been discharged from hospital and investigate the associated risk factors, in particular disease severity.
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TL;DR: In this article, the authors evaluated 109 survivors of the acute respiratory distress syndrome 3, 6, and 12 months after discharge from the intensive care unit, and found that muscle weakness and fatigue were the reasons for their functional limitation.
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Yumiao Zhao,Yao-min Shang,Wen-bin Song,Qingquan Li,Hua Xie,Qin-Fu Xu,Jia Junli,Li-ming Li,Hong-li Mao,Xiuman Zhou,Hong Luo,Yan-feng Gao,Ai-Guo Xu +12 more
TL;DR: Radiological and physiological abnormalities were still found in a considerable proportion of COVID-19 survivors without critical cases 3 months after discharge, and higher level of D-dimer levels on admission could effectively predict impaired DLCO after 3 months discharge.
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Abnormal pulmonary function in COVID-19 patients at time of hospital discharge.
Xiaoneng Mo,Wenhua Jian,Zhu-Quan Su,Mu Chen,Hui Peng,Ping Peng,Chunliang Lei,Ruchong Chen,Nanshan Zhong,Shiyue Li +9 more
TL;DR: In discharged survivors with COVID-19, impairment of diffusion capacity is the most common abnormality of lung function, followed by restrictive ventilatory defects, which are both associated with the severity of the disease.
Journal ArticleDOI
Factors Associated With Prolonged Viral RNA Shedding in Patients with Coronavirus Disease 2019 (COVID-19).
Kaijin Xu,Yanfei Chen,Jing Yuan,Ping Yi,Cheng Ding,Wenrui Wu,Yongtao Li,Qin Ni,Rongrong Zou,Xiaohe Li,Min Xu,Ying Zhang,Hong Zhao,Xuan Zhang,Liang Yu,Junwei Su,Guanjing Lang,Jun Liu,Xiaoxin Wu,Yongzheng Guo,Jingjing Tao,Ding Shi,Ling Yu,Qing Cao,Bing Ruan,Lei Liu,Zhaoqin Wang,Yan Xu,Yingxia Liu,Jifang Sheng,Lanjuan Li +30 more
TL;DR: Male sex, delayed admission to hospital after illness onset, and invasive mechanical ventilation were associated with prolonged SARS-CoV-2 RNA shedding and hospital admission and general treatments should be started as soon as possible in symptomatic COVID-19 patients, especially male patients.