Aceturato de diminazeno e dipropionato de imidocarb no controle de infecção por Trypanosoma evansi em Rattus norvegicus infectados experimentalmente
Aleksandro Schafer da Silva,Camila Tochetto,Régis Adriel Zanette,Felipe Pierezan,Daniel R. Rissi,Janio Morais Santurio,Silvia Gonzalez Monteiro +6 more
TLDR
Dinazene aceturate is effective in treating trypanosomosis in rats when used five days consecutively and resulted in elimination of the trypomastigotes from circulation.Abstract:
The aim of this study was to evaluate the efficacy of diminazene aceturate and imidocarb dipropionate in the control of Trypanosoma evansi infection in rats (Rattus norvegicus) experimentally infected. Fifty-four male rats were inoculated through intraperitoneal route with 104 T. evansi trypomastigotes. The rats were evaluated daily by periferic blood smears examination and treated when eight flagellated parasites were observed in 1000x microscopic field. Two therapeutics protocols were used. The first one included Groups A, B, C, D in which the rats were submitted to a single dose of the testing drugs administered by intramuscular route at the day 0 and again when T. evansi was observed in the blood smears. The rats of the second protocol (Groups E, F, G, H) were submitted to the same treatment by five consecutive days. Four rats (Group I) were used as control and were not submitted to any treatment. Tested drugs did not show any curative effect when used in the first protocol, since parasitaemia was evident few days after treatment. The use of diminazene aceturate in the second protocol resulted in elimination of the trypomastigotes from circulation. In this case the rats were euthanized at the day 90. The infection recurred 30 days after the administration of imidocarb dipropionate. Histologically, no lesions were found in the liver or kidney. Diminazene aceturate is effective in treating trypanosomosis in rats when used five days consecutively.read more
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Canine trypanosomiasis: etiology of infection and implications for public health
TL;DR: Etiological, epidemiological and public health aspects of canine trypanosomiasis, and the most important peculiarities of this zoonosis in dogs are reported.
Journal ArticleDOI
Diminazene aceturate—An antiparasitic drug of antiquity: Advances in pharmacology & therapeutics
TL;DR: A systematic review on diminazene aceturate regarding its pharmacological properties suggested promising new applications such as leishmanicidal, amebicidal,anti-pneumocystis, anti-rheumatoid arthritis, antihypertensive agent and mainly as an activator of angiotensin-converting enzyme 2.
Journal ArticleDOI
Diminazene aceturate in the control of Trypanosoma evansi infection in cats.
A. S. da Silva,Régis Adriel Zanette,Patrícia Wolkmer,Mateus Matiuzzi da Costa,H.A. Garcia,Sonia Terezinha dos Anjos Lopes,Jânio Morais Santúrio,M.M.G. Teixeira,Silvia Gonzalez Monteiro +8 more
TL;DR: The therapy used is effective in controlling T. evansi in cats andAlanine aminotransferase, gamma-glutamyltransferase, urea, and creatinine values remained within the normal physiological range in the treated cats.
Journal ArticleDOI
Tripanossomose em equinos na região sul do Brasil
Aleksandro Schafer da Silva,Olmiro Adair Silveira de Andrade Neto,Márcio Machado Costa,Patrícia Wolkmer,Cinthia Melazzo Mazzantti,Janio Morais Santurio,Sonia Terezinha dos Anjos Lopes,Silvia Gonzalez Monteiro +7 more
TL;DR: The outbreaks of the infection by T. evansi in horses that occurred in southern Brazil were discussed in terms of epidemiology, clinical signs, laboratory tests, pathological findings, diagnosis and treatment by addressing the differences between the cases occurred in the state of Rio Grande do Sul and in other Brazilian states.
Journal ArticleDOI
Susceptibility of Trypanosoma evansi to propolis extract in vitro and in experimentally infected rats.
Lucas T. Gressler,Aleksandro Schafer da Silva,Gustavo Machado,Luciana Dalla Rosa,Fellipe de Souza Dorneles,Letícia Trevisan Gressler,Maurício Schneider Oliveira,Régis Adriel Zanette,Agueda Castangna Vargas,Silvia Gonzalez Monteiro +9 more
TL;DR: Despite the lack of curative efficacy observed in vivo at the concentrations tested, the propolis extract can prolong life in rats infected with the protozoan.
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