Journal ArticleDOI
Diminazene aceturate—An antiparasitic drug of antiquity: Advances in pharmacology & therapeutics
TLDR
A systematic review on diminazene aceturate regarding its pharmacological properties suggested promising new applications such as leishmanicidal, amebicidal,anti-pneumocystis, anti-rheumatoid arthritis, antihypertensive agent and mainly as an activator of angiotensin-converting enzyme 2.About:
This article is published in Pharmacological Research.The article was published on 2015-12-01. It has received 41 citations till now. The article focuses on the topics: Diminazene & Antiparasitic agent.read more
Citations
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Journal ArticleDOI
Ellagic acid microspheres restrict the growth of Babesia and Theileria in vitro and Babesia microti in vivo
Amani Magdy Beshbishy,Gaber El-Saber Batiha,Gaber El-Saber Batiha,Naoaki Yokoyama,Ikuo Igarashi +4 more
TL;DR: This is the first study to demonstrate the in vitro and in vivo antibabesial action of EA-NPs and thus supports the use of nanoparticles as an alternative antiparasitic agent.
Journal ArticleDOI
Angiotensin converting enzyme 2 and diminazene: role in cardiovascular and blood pressure regulation.
TL;DR: Experimental studies that have used the off-target effects of the antitrypanosomal agent, diminazene aceturate (DIZE) to activate ACE2 and evaluate its therapeutic potential in comparison with currently available clinical interventions are focused on.
Journal ArticleDOI
The ACE 2 activator diminazene aceturate (DIZE) improves left ventricular diastolic dysfunction following myocardial infarction in rats.
Carmen Castardeli,Carmem Luíza Sartório,Enildo Broetto Pimentel,Ludmila Forechi,José Geraldo Mill +4 more
TL;DR: The findings show that chronic DIZE treatment post-MI attenuates the morphofunctional changes induced by MI in rats, and suggest this drug can be used as a therapeutic agent to reduce interstitial fibrosis and diastolic dysfunction after MI.
Journal ArticleDOI
Angiotensin II Receptors - Impact for COVID-19 Severity.
TL;DR: Patients with SARS‐CoV‐2 infection may benefit from therapeutic strategies that activate ACE2‐Ang 1‐7‐Mas axis, such as Ang II receptor blockers (ARBs), ACE inhibitors (ACEIs), Mas receptor agonists and ACE2.
Journal ArticleDOI
17-DMAG inhibits the multiplication of several Babesia species and Theileria equi on in vitro cultures, and Babesia microti in mice.
Azirwan Guswanto,Arifin Budiman Nugraha,Bumduuren Tuvshintulga,Dickson Stuart Tayebwa,Mohamed Abdo Rizk,Gaber El-Saber Batiha,Sambuu Gantuya,Thillaiampalam Sivakumar,Naoaki Yokoyama,Ikuo Igarashi +9 more
TL;DR: 17-DMAG is a potent drug for treating piroplamosis and as an option in combination with atovaquone for the treatment of human babesiosis, and the two-drug combination of 17- DMAG with diminazene aceturate (DA) and atOVAquone (AV) showed synergism or addition on in vitro cultures of Babesia and Theileria parasites.
References
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Journal ArticleDOI
Drugs and drug resistance in African trypanosomiasis.
V. Delespaux,Harry P. de Koning +1 more
TL;DR: The use of current drugs against human and veterinary African trypanosomiasis, the prevalence, causes and mechanisms of drug resistance and new developments in trypanOSomiasis therapy such as the introduction of nifurtimox and DB289 are discussed.
Journal ArticleDOI
DNA minor groove-binding ligands: a different class of mammalian DNA topoisomerase I inhibitors
TL;DR: The results suggest that MGBLs, like camptothecin, abort Topo I reactions by trapping reversible cleavable complexes, and DNA topoisomerase (Topo) I may be a pharmacological target of M GBLs.
Journal ArticleDOI
Current Advances in Detection and Treatment of Babesiosis
TL;DR: The post-genomic era brings a new light on the development of diagnosis methods and new chemotherapy targets for babesiosis, with additional reference to several apicomplexan parasites.
Journal ArticleDOI
Chemotherapy against babesiosis.
Henri Vial,André Gorenflot +1 more
TL;DR: Clinical manifestations differ markedly between European and North American diseases, and a combination of clindamycin and quinine is administered as the standard treatment, but also administration of atovaquone-azithromycin is successful.
Related Papers (5)
Diminazene aceturate (Berenil), a new use for an old compound?
Shiby Kuriakose,Jude E. Uzonna +1 more