Journal ArticleDOI
Pharmacology of diminazene. A review
A.S. Peregrine,M. Mamman +1 more
TLDR
The current status of knowledge concerning the therapeutic spectrum of Diminazene, resistance to diminazene in trypanosomes, and combination therapeutic regimens in which diminazenes has been administered together with other compounds are considered.About:
This article is published in Acta Tropica.The article was published on 1993-09-01. It has received 185 citations till now. The article focuses on the topics: Diminazene.read more
Citations
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Journal ArticleDOI
Human African trypanosomiasis: pharmacological re-engagement with a neglected disease
TL;DR: The challenges of chemotherapy for human African trypanosomiasis (HAT) are discussed, and the few drugs registered for use against the disease are unsatisfactory for a number of reasons.
Journal ArticleDOI
The vasoprotective axes of the renin-angiotensin system: Physiological relevance and therapeutic implications in cardiovascular, hypertensive and kidney diseases.
TL;DR: The roles and therapeutic implications of the vasoprotective axes of the RAS in cardiovascular, hypertensive and kidney diseases are reviewed.
Journal ArticleDOI
Drugs and drug resistance in African trypanosomiasis.
V. Delespaux,Harry P. de Koning +1 more
TL;DR: The use of current drugs against human and veterinary African trypanosomiasis, the prevalence, causes and mechanisms of drug resistance and new developments in trypanOSomiasis therapy such as the introduction of nifurtimox and DB289 are discussed.
Journal ArticleDOI
The animal trypanosomiases and their chemotherapy: a review.
TL;DR: This review provides a comprehensive overview of the current options available for the treatment and prophylaxis of the animal trypanosomiases, with a special focus on the problem of resistance.
Journal ArticleDOI
Current Advances in Detection and Treatment of Babesiosis
TL;DR: The post-genomic era brings a new light on the development of diagnosis methods and new chemotherapy targets for babesiosis, with additional reference to several apicomplexan parasites.
References
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Journal ArticleDOI
Selective cleavage of kinetoplast DNA minicircles promoted by antitrypanosomal drugs.
TL;DR: Selective inhibition of a mitochondrial type II topoisomerase may explain why these antitrypanosomal drugs preferentially disrupt mitochondrial DNA structure and generate dyskinetoplastic trypanosomes (which lack mitochondrial DNA).
Journal ArticleDOI
The brain as a source of relapsing Trypanosoma brucei infection in mice after chemotherapy.
TL;DR: During the aparasitaemic period following chemotherapy of all three strains of T. brucei infections in mice, successful transmission as shown by subsequent parasitaemia, was regularly achieved following the inoculation of homogenates of brain tissue into recipient mice.
Journal ArticleDOI
The relationship between duration of infection with Trypanosoma brucei in mice and the efficacy of chemotherapy.
TL;DR: In this article, the authors showed that mice with T. brucei TREU 667 infection with Ethidium and Prothidium at dose levels of 7.5 and 10 mg/kg respectively were also followed by relapse if treatment was delayed for 3 weeks after infection.
Journal ArticleDOI
Epidemiology of bovine trypanosomiasis in the Ghibe valley, southwest Ethiopia. 3. Occurrence of populations of Trypanosoma congolense resistant to diminazene, isometamidium and homidium
V. Codjia,Woudyalew Mulatu,Phelix A.O. Majiwa,S.G.A. Leak,G.J. Rowlands,Edith Authié,G.D.M. D'Ieteren,A.S. Peregrine +7 more
TL;DR: Six different karyotypes were observed and all eight of the latter isolates belonged to different zymodemes, indicating that the multi-resistance phenotype at Ghibe was associated with many genetically distinct populations.
Related Papers (5)
Diminazene attenuates pulmonary hypertension and improves angiogenic progenitor cell functions in experimental models.
Vinayak Shenoy,Altin Gjymishka,Yagna P. R. Jarajapu,Yanfei Qi,Aqeela Afzal,Katya Rigatto,Anderson J. Ferreira,Rodrigo A. Fraga-Silva,Patrick Kearns,Jane Yellowlees Douglas,Deepmala Agarwal,Kamal K. Mubarak,Chastity Bradford,William R. Kennedy,Joo Yun Jun,Anandharajan Rathinasabapathy,Erin Bruce,Dipankar Gupta,Arturo J. Cardounel,J Mocco,Jawaharlal M. Patel,Jawaharlal M. Patel,Joseph Francis,Maria B. Grant,Michael J. Katovich,Mohan K. Raizada +25 more