Journal ArticleDOI
Acromegaly and the Cardiovascular System
TLDR
Control of acromegaly by surgery or pharmacotherapy could improve cardiovascular morbidity thanks to decreasing left ventricular mass and reducing cardiac dysfunction, and an early diagnosis and a careful evaluation of cardiac function, morphology and activity seem to be mandatory.Abstract:
Acromegaly is characterized by an increased cardiovascular morbidity and mortality. In fact, growth hormone and insulin-like growth factor-I excess induces a specific cardiomyopathy. The heart is involved from the very early stages of the disease in which the hyperkinetic syndrome (high heart rate and increased systolic output) takes place. Frequently, if the disease is untreated for many years or unsuccessfully treated, concentric biventricular hypertrophy and diastolic dysfunction can develop and, at least, lead to diastolic congestive heart failure. Rhythm disturbances and valve dysfunction are also frequently described in acromegaly. The coexistence of other complications, such as diabetes and arterial hypertension, can induce the worsening of acromegalic cardiomyopathy. Control of acromegaly by surgery or pharmacotherapy could improve cardiovascular morbidity thanks to decreasing left ventricular mass and reducing cardiac dysfunction. In conclusion, an early diagnosis and a careful evaluation of cardiac function, morphology and activity seem to be mandatory in acromegaly.read more
Citations
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Journal ArticleDOI
Clinical practice guidelines for multiple endocrine neoplasia type 1 (MEN1)
Rajesh V. Thakker,Paul J. Newey,Gerard V Walls,John P. Bilezikian,Henning Dralle,Peter R. Ebeling,Shlomo Melmed,Akihiro Sakurai,Francesco Tonelli,Maria Luisa Brandi +9 more
TL;DR: It is recommended that MEN1 patients and their families should be cared for by multidisciplinary teams comprising relevant specialists with experience in the diagnosis and treatment of patients with endocrine tumors.
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Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer
Gary L. Francis,Steven G. Waguespack,Andrew J. Bauer,Peter Angelos,Salvatore Benvenga,Janete M. Cerutti,Catherine A. Dinauer,Jill Hamilton,Ian D. Hay,Markus Luster,Marguerite T. Parisi,Marianna Rachmiel,Geoffrey B. Thompson,Shunichi Yamashita +13 more
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Diastolic Heart Failure
TL;DR: In this paper, a 78-year-old woman with a history of hypertension is admitted to the hospital with congestive heart failure, and physical examination reveals a blood pressure of 180/90 mm Hg, increased jugular venous pressure, peripheral edema and pulmonary rales.
Journal ArticleDOI
American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the Diagnosis and Treatment of Acromegaly-2011 Update
Laurence Katznelson,John L.D. Atkinson,David M. Cook,Shereen Ezzat,Amir H. Hamrahian,Karen K. Miller +5 more
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Cardiovascular phenotype in Turner syndrome--integrating cardiology, genetics, and endocrinology.
TL;DR: An up-to-date condensation of current state-of-the-art knowledge in Turner syndrome provides insight into pathogenesis of Turner syndrome with perspectives to advances in the understanding of genetics of the X-chromosome.
References
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Journal ArticleDOI
Systemic complications of acromegaly: epidemiology, pathogenesis, and management.
TL;DR: The most important cause of morbidity and functional disability of this disease is arthropathy, which can be reversed at an initial stage, but not if the disease is left untreated for several years.
Journal ArticleDOI
Diastolic heart failure
TL;DR: A 78-year-old woman with a history of hypertension is admitted to the hospital with congestive heart failure and physical examination reveals a blood pressure of 180/90 mm Hg, increased jugular venous pressure, peripheral edema, and pulmonary rales.
Journal Article
Diastolic Heart Failure
TL;DR: In this paper, a 78-year-old woman with a history of hypertension is admitted to the hospital with congestive heart failure, and physical examination reveals a blood pressure of 180/90 mm Hg, increased jugular venous pressure, peripheral edema and pulmonary rales.
Journal ArticleDOI
Growth hormone and the heart
TL;DR: Several lines of evidence have suggested that the cardiovascular abnormalities can be partially reversed by suppressing GH and IGF‐I levels in acromegaly or after GH replacement therapy in GHD patients.