Journal ArticleDOI
Action of baclofen on mammalian synaptic transmission.
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TLDR
Microiontophoretic and systemic injections were used to investigate the mechanism of baclofen's powerful depressant action on transmission at primary afferent synapses in the cat and depressed the spontaneous and evoked activity of cuneate cells and reduced the excitability and input resistance of spinal motoneurones.About:
This article is published in Neuroscience.The article was published on 1978-06-01. It has received 199 citations till now. The article focuses on the topics: Baclofen & Inhibitory postsynaptic potential.read more
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Book
The synaptic organization of the brain
TL;DR: Introduction to synaptic circuits, Gordon M.Shepherd and Christof Koch membrane properties and neurotransmitter actions, David A.Brown and Anthony M.Brown.
Journal ArticleDOI
Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor
TL;DR: GABA clearly decreased the evoked release of accumulated 3H-noradrenaline from rat atria in vitro and3H-acetylcholine from preganglionic terminals in the rat superior cervical ganglion in vitro without affecting the basal release of tritium.
Journal ArticleDOI
Synaptic Control of Motoneuronal Excitability
TL;DR: A background description of motoneurons: their development, anatomical organization, and membrane properties, both passive and active, and a description of the major transmitter systems that affect mot oneuronal excitability, focusing on synaptic and cellular properties.
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GABA receptor mechanisms in the central nervous system.
Lucia G. Sivilotti,A. Nistri +1 more
References
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Journal ArticleDOI
Substance p: localization in the central nervous system and in some primary sensory neurons
TL;DR: Results give morphological support for a transmitter (or modulator) role of substance P in the nervous system of the rat and the cat.
Journal ArticleDOI
Immunohistochemical evidence for separate populations of somatostatin-containing and substance P-containing primary afferent neurons in the rat.
Tomas Hökfelt,Tomas Hökfelt,Robert Elde,Robert Elde,O. Johansson,O. Johansson,R. Luft,R. Luft,G. Nilsson,G. Nilsson,Akira Arimura,Akira Arimura +11 more
TL;DR: The present results indicate that two subpopulations of primary sensory neurons exist, one containing somatostatin, or som atostatin-like immunoreactivity, and the other containing substance P, or substance P-like Immunoreactivity.
Journal ArticleDOI
Iontophoretic studies of neurones in the mammalian cerebral cortex.
K. Krnjević,J. W. Phillis +1 more
TL;DR: Iontophoresis has been used extensively in experiments on spinal neurones and also in two studies of neurones in the brain stem, and is the method of choice whenever the substance is ionized in solution.
Journal ArticleDOI
Dendritic location of synapses and possible mechanisms for the monosynaptic EPSP in motoneurons.
TL;DR: The purpose of this paper is to determine whether the experimental data will allow us to put some restrictions on the model parameters which determine EPSP shapes and to provide a more sharply defined picture of the organizati on of synapses on the motoneuronal soma and dendritic tree.
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