Acute Myocardial Infarction and Myocarditis following COVID-19 Vaccination.
Yin Nwe Aye,Aaron Shengting Mai,Audrey Zhang,Oliver Zi Hern Lim,Norman Lin,Cheng Han Ng,Mark Y Chan,James Yip,Poay-Huan Loh,Nicholas Chew +9 more
TLDR
A pooled analysis of patients presenting with cardiac manifestations following COVID-19 vaccination highlights the differences between myocarditis and acute myocardial infarction (AMI) presentations in temporal association with the vaccination as mentioned in this paper.Abstract:
Background Emerging reports raise concerns on the potential association between the COVID-19 vaccines and cardiac manifestations. We sought to evaluate cardiac complications associated with COVID-19 vaccination in a pooled analysis from our institution's cohort study and systematic review. Methods Consecutive patients admitted in a tertiary hospital in Singapore between 1 January 2021 and 31 March 2021, with onset of cardiac manifestations within 14 days following COVID-19 vaccination were studied. Furthermore, a systematic review was performed, with PubMed, Embase, Research Square, MedRxiv, and LitCovid databases accessed from inception up to 29 June 2021. Relevant manuscripts reporting individual patient data on cardiac complications following COVID-19 vaccination were included. Results Thirty patients were included in the study cohort, with 29 diagnosed with acute myocardial infarction (AMI) and 1 with myocarditis. Five patients developed heart failure, two had cardiogenic shock, three intubated, and one had cardiovascular-related mortality. In the systematic review, 16 studies were included with 41 myocarditis and six AMI cases. In the pooled analysis of the study cohort and the systematic review, 35 patients had AMI and 42 had myocarditis. Majority were men, and myocarditis patients were younger than AMI patients. Myocarditis patients tended to present 72 hours post-vaccination, while AMI patients were older and typically presented 24 hours post-vaccination. Majority with AMI or myocarditis developed symptoms after the first and second vaccination dose respectively. Conclusions This pooled analysis of patients presenting with cardiac manifestations following COVID-19 vaccination highlights the differences between myocarditis and AMI presentations in temporal association with the vaccination.read more
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Epidemiology, clinical ramifications, and cellular pathogenesis of COVID-19 mRNA-vaccination-induced adverse cardiovascular outcomes: A state-of-the-heart review
Talal Almas,Sarah Rehman,Eyad Mansour,Tarek Khedro,Aliya Alansari,Jahanzeb Malik,Norah Alshareef,V. Nagarajan,Abdullah Al-Awaid,Reema Alsufyani,Majid Alsufyani,Alila Nur Aza Rifai,Ahlam A. Alzahrani,Dhineswaran Raj Nagarajan,Tala Abdullatif,Varman Gunasaegaram,Enaam Alzadjali,Arthi Subramanian,A. S. M. Zisanur Rahman,Yasar Sattar,Jason Galo,Hafeez Ul Hassan Virk,M. Chadi Alraies +22 more
TL;DR: In this paper , the authors aim to critically appraise the available literature regarding the cardiovascular side effects of the various mRNA vaccines and the associated pathophysiology, and they aim to identify the most commonly reported sequelae post vaccination.
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Profiling COVID-19 Vaccine Adverse Events by Statistical and Ontological Analysis of VAERS Case Reports
Wenxin Guo,Jessica Deguise,Yujia Tian,Philip Chi-En Huang,Rohit Goru,Qiuyue Yang,Suyuan Peng,Luxia Zhang,Lili Zhao,Jiangan Xie,Yongqun He +10 more
TL;DR: Notably, severe COVID-19 vaccine AEs (including myocarditis, GBS, and TTS) rarely occur in comparison to the large number of COvid-19 vaccinations administered in the United States, affirming the overall safety of these CO VID-19 vaccines.
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Signaling COVID-19 Vaccine Adverse Events
Rave Harpaz,William DuMouchel,Robbert P. van Manen,Alexander Nip,Steve Bright,Ana Szarfman,Joseph M. Tonning,Magnus Lerch +7 more
TL;DR: In this article , the authors investigate the problem of masking in the context of COVID-19 vaccine signal detection, assessing its impact, extent, and root causes, based on data underlying the Vaccine Adverse Event Reporting System, three commonly applied statistical signal detection methodologies, and a more advanced regression-based methodology.
References
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TL;DR: In this article, the authors reported several cases of unusual thrombotic events and thrombo-cellocytopenia after vaccination with the recombinant adenoviral vector encoding the spike protein antigen of spike proteins.
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Covid-19: European countries suspend use of Oxford-AstraZeneca vaccine after reports of blood clots.
TL;DR: Denmark has temporarily suspended use of the Oxford-AstraZeneca covid-19 vaccine as a precautionary move after reports of blood clots and one death.