Covid-19: European countries suspend use of Oxford-AstraZeneca vaccine after reports of blood clots.
Reads0
Chats0
TLDR
Denmark has temporarily suspended use of the Oxford-AstraZeneca covid-19 vaccine as a precautionary move after reports of blood clots and one death.Abstract:
Denmark has temporarily suspended use of the Oxford-AstraZeneca covid-19 vaccine as a precautionary move after reports of blood clots and one death. However, the European Medicines Agency (EMA) and the UK’s regulatory body have said that there is no indication that vaccination is linked to thromboembolic events.
Eight other countries—Norway, Iceland, Austria, Estonia, Lithuania, Luxembourg, Italy, and Latvia—have also suspended use of AstraZeneca’s vaccine. The decisions are a further setback for Europe’s vaccination campaign, which has struggled to pick up speed, partly because of delays in delivering the AstraZeneca vaccine.
The Danish Health Authority said that one person in Denmark had died after receiving the AstraZeneca vaccine and that it would suspend the drug’s use for two weeks while the case was investigated. “It is important to point out that we have not terminated the use of the AstraZeneca vaccine—we are just pausing its use,” said the Danish Health Authority’s director, Soren Brostrom.
On 10 …read more
Citations
More filters
Journal ArticleDOI
Immune responses against SARS-CoV-2 variants after heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination.
Joana Barros-Martins,Swantje I. Hammerschmidt,Anne Cossmann,Ivan Odak,Metodi V. Stankov,Gema Morillas Ramos,Alexandra Dopfer-Jablonka,Annika Heidemann,Christiane Ritter,Michaela Friedrichsen,Christian Schultze-Florey,Inga Ravens,Stefanie Willenzon,Anja Bubke,Jasmin Ristenpart,Anika Janssen,George Ssebyatika,Günter Bernhardt,Jan Münch,Markus Hoffmann,Markus Hoffmann,Stefan Pöhlmann,Stefan Pöhlmann,Thomas Krey,Berislav Bošnjak,Reinhold Förster,Georg M. N. Behrens +26 more
TL;DR: In this article, the authors used the COVID-19 Contact Study cohort of healthcare professionals to monitor ChAd-primed immune responses before and 3 weeks after booster with ChAd or BioNTech/Pfizer's BNT162b2 (n = 55).
Journal ArticleDOI
Arterial events, venous thromboembolism, thrombocytopenia, and bleeding after vaccination with Oxford-AstraZeneca ChAdOx1-S in Denmark and Norway: population based cohort study.
Anton Pottegård,Lars Christian Lund,Øystein Karlstad,Jesper Dahl,Morten Andersen,Jesper Hallas,Øjvind Lidegaard,German Tapia,Hanne Løvdal Gulseth,Paz Lopez-Doriga Ruiz,Sara Sofie Viksmoen Watle,Anders P. Mikkelsen,Lars Pedersen,Lars Pedersen,Henrik Toft Sørensen,Henrik Toft Sørensen,Reimar W. Thomsen,Reimar W. Thomsen,Anders Hviid,Anders Hviid +19 more
TL;DR: In this paper, the authors assess rates of cardiovascular and haemostatic events in the first 28 days after vaccination with the Oxford-AstraZeneca vaccine ChAdOx1-S in Denmark and Norway and compare them with rates observed in the general populations.
Journal ArticleDOI
Efficacy and Safety of COVID-19 Vaccines: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Ali Pormohammad,Mohammad Zarei,Saied Ghorbani,Mehdi Mohammadi,Mohammad Hossein Razizadeh,Diana L. Turner,Raymond J. Turner +6 more
TL;DR: The current study systematically reviewed, summarized and meta-analyzed the clinical features of the vaccines in clinical trials to provide a better estimate of their efficacy, side effects and immunogenicity and found the adenovirus-vectored and mRNA-based vaccines showed the highest efficacy after first and second doses, respectively.
Journal ArticleDOI
First-dose ChAdOx1 and BNT162b2 COVID-19 vaccines and thrombocytopenic, thromboembolic and hemorrhagic events in Scotland.
Colin R Simpson,Colin R Simpson,Ting Shi,Eleftheria Vasileiou,Srinivasa Vittal Katikireddi,Shona M. Kerr,Emily Moore,Colin McCowan,Utkarsh Agrawal,Syed Ahmar Shah,Lewis D Ritchie,Josie Murray,Jiafeng Pan,Declan Bradley,Sarah J. Stock,Rachael Wood,Antony Chuter,Jillian Beggs,Helen R. Stagg,Mark Joy,Ruby S. M. Tsang,S de Lusignan,Richard J. Hobbs,Ronan A Lyons,Fatemeh Torabi,Stuart Bedston,M O'Leary,Ashley Akbari,Jim McMenamin,Chris Robertson,Aziz Sheikh +30 more
TL;DR: In this article, an association was found between exposure to first-dose ChAdOx1 or BNT162b2 vaccination and hematological and vascular adverse events using a nested incident-matched case-control study and a confirmatory self-controlled case series (SCCS) analysis.
Journal ArticleDOI
Emerging COVID-19 variants and their impact on SARS-CoV-2 diagnosis, therapeutics and vaccines
Queenie Fernandes,Varghese Inchakalody,Maysaloun Merhi,Sarra Mestiri,Nassiba Taib,Dina Moustafa Abo El-Ella,Takwa Bedhiafi,Afsheen Raza,Lobna Al-Zaidan,Mona O. Mohsen,Mariam Ali Yousuf Al-Nesf,Ali Ait Hssain,Hadi M. Yassine,Martin F. Bachmann,Shahab Uddin,Said Dermime +15 more
TL;DR: An updated perspective is provided on the current challenges posed by the emergence of novel SARS-CoV-2 mutants/variants and the evolution of diagnostic techniques to enable their detection and the development, formulation, working mechanisms, advantages, and drawbacks of some of the most used vaccines/therapeutic drugs.
Related Papers (5)
Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK.
Merryn Voysey,Clemens Sac.,Shabir A. Madhi,Lily Yin Weckx,P M Folegatti,Parvinder K. Aley,Brian Angus,Vicky L. Baillie,Shaun Barnabas,Q E Bhorat,S Bibi,Carmen Briner,P Cicconi,Andrea M. Collins,R Colin-Jones,Clare L. Cutland,Thomas C. Darton,Keertan Dheda,Duncan Cja.,Emary Krw.,Katie J. Ewer,Lee Fairlie,Saul N. Faust,Shuo Feng,Daniela M. Ferreira,Adam Finn,Anna Goodman,Catherine M. Green,Christopher A Green,Paul T. Heath,Christopher Hill,Helen Hill,Ian Hirsch,Hodgson Shc.,Allen Izu,S Jackson,D Jenkin,Joe Ccd.,S Kerridge,Anthonet Koen,Gaurav Kwatra,Rajeka Lazarus,Alison M. Lawrie,A Lelliott,Vincenzo Libri,Patrick J. Lillie,R Mallory,Mendes Ava.,Eveline Pipolo Milan,Angela M. Minassian,Alastair McGregor,Hazel Morrison,Y Mujadidi,Amit J Nana,P J O’Reilly,S D Padayachee,A Pittella,E Plested,Katrina M Pollock,M N Ramasamy,S Rhead,Alexandre Vargas Schwarzbold,Nisha Singh,Andrew Smith,R Song,Matthew D. Snape,Eduardo Sprinz,Rebecca K. Sutherland,R Tarrant,E. Thomson,M E Török,Mark Toshner,Turner Dpj.,Johan Vekemans,Tonya Villafana,Watson Mee.,C J Williams,Alexander D. Douglas,Hill Avs.,Teresa Lambe,Sarah C. Gilbert,Andrew J. Pollard +81 more
Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine.
Fernando P. Polack,Stephen J. Thomas,Nicholas Kitchin,Judith Absalon,Alejandra Gurtman,Stephen Lockhart,John L. Perez,Gonzalo Pérez Marc,Edson D. Moreira,Cristiano Zerbini,Ruth Bailey,Kena A. Swanson,Satrajit Roychoudhury,Kenneth Koury,Ping Li,Warren Kalina,David A. Cooper,Robert W. Frenck,Laura L. Hammitt,Özlem Türeci,Haylene Nell,Axel Schaefer,Serhat Ünal,Dina B. Tresnan,Susan Mather,Philip R. Dormitzer,Ugur Sahin,Kathrin U. Jansen,William C. Gruber +28 more
Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine.
Lindsey R. Baden,Hana M. El Sahly,Brandon Essink,Karen L. Kotloff,Sharon E. Frey,Rick Novak,David Diemert,Stephen A. Spector,Nadine Rouphael,C. Buddy Creech,John W McGettigan,Shishir Khetan,Nathan Segall,Joel Solis,Adam Brosz,Carlos Fierro,Howard J. Schwartz,Kathleen M. Neuzil,Lawrence Corey,Peter B. Gilbert,Holly Janes,Dean Follmann,Mary A. Marovich,John R. Mascola,Laura Polakowski,Julie E. Ledgerwood,Barney S. Graham,Hamilton Bennett,Rolando Pajon,Conor Knightly,Brett Leav,Weiping Deng,Honghong Zhou,Shu Liang Han,Melanie Ivarsson,Jacqueline Miller,Tal Z Zaks +36 more
Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia.
Denis Y. Logunov,Inna V. Dolzhikova,Dmitry V. Shcheblyakov,A. I. Tukhvatulin,Olga V. Zubkova,Alina S. Dzharullaeva,Anna V. Kovyrshina,Nadezhda L. Lubenets,Daria M. Grousova,Alina S. Erokhova,Andrei G. Botikov,Fatima M. Izhaeva,Olga Popova,Tatiana A Ozharovskaya,Ilias B Esmagambetov,Irina A Favorskaya,Denis I. Zrelkin,Daria V Voronina,Dmitry N. Shcherbinin,Alexander S. Semikhin,Yana V. Simakova,Elizaveta A. Tokarskaya,Daria A. Egorova,M M Shmarov,Natalia A. Nikitenko,Vladimir A. Gushchin,Elena A Smolyarchuk,Sergey Zyryanov,Sergei V. Borisevich,Boris S. Naroditsky,Alexander L. Gintsburg +30 more