M
Masao Moroi
Researcher at Toho University
Publications - 148
Citations - 5368
Masao Moroi is an academic researcher from Toho University. The author has contributed to research in topics: Coronary artery disease & Medicine. The author has an hindex of 27, co-authored 126 publications receiving 4898 citations.
Papers
More filters
Journal ArticleDOI
Disruption of adiponectin causes insulin resistance and neointimal formation.
Naoto Kubota,Yasuo Terauchi,Toshimasa Yamauchi,Tetsuya Kubota,Masao Moroi,Junji Matsui,Kazuhiro Eto,Tokuyuki Yamashita,Junji Kamon,Hidemi Satoh,Wataru Yano,Philippe Froguel,Ryozo Nagai,Satoshi Kimura,Takashi Kadowaki,Tetsuo Noda,Tetsuo Noda +16 more
TL;DR: This study provides the first direct evidence that adiponectin plays a protective role against insulin resistance and atherosclerosis in vivo.
Journal ArticleDOI
Adiponectin Stimulates AMP-Activated Protein Kinase in the Hypothalamus and Increases Food Intake
Naoto Kubota,Wataru Yano,Tetsuya Kubota,Tetsuya Kubota,Toshimasa Yamauchi,Shinsuke Itoh,Hiroki Kumagai,Hideki Kozono,Iseki Takamoto,Shiki Okamoto,Tetsuya Shiuchi,Ryo Suzuki,Hidemi Satoh,Atsushi Tsuchida,Masao Moroi,Kaoru Sugi,Tetsuo Noda,Tetsuo Noda,Hiroyuki Ebinuma,Yoichi Ueta,Tatsuya Kondo,Eiichi Araki,Osamu Ezaki,Ryozo Nagai,Kazuyuki Tobe,Yasuo Terauchi,Kohjiro Ueki,Yasuhiko Minokoshi,Takashi Kadowaki +28 more
TL;DR: It is shown that adiponectin stimulates food intake and decreases energy expenditure during fasting through its effects in the central nervous system via its receptor AdipoR1 to stimulate food intake.
Journal ArticleDOI
Impaired Insulin Signaling in Endothelial Cells Reduces Insulin-Induced Glucose Uptake by Skeletal Muscle
Tetsuya Kubota,Naoto Kubota,Hiroki Kumagai,Shinichi Yamaguchi,Hideki Kozono,Takehiro Takahashi,Mariko Inoue,Shinsuke Itoh,Iseki Takamoto,Takayoshi Sasako,Katsuyoshi Kumagai,Tomoko Kawai,Shinji Hashimoto,Tsuneo Kobayashi,Maki Sato,Kumpei Tokuyama,Satoshi Nishimura,Masaki Tsunoda,Tomohiro Ide,Koji Murakami,Tomomi Yamazaki,Osamu Ezaki,Koichi Kawamura,Hirotake Masuda,Masao Moroi,Kaoru Sugi,Yuichi Oike,Hiroaki Shimokawa,Nobuyuki Yanagihara,Masato Tsutsui,Yasuo Terauchi,Kazuyuki Tobe,Ryozo Nagai,Katsuo Kamata,Kenji Inoue,Tatsuhiko Kodama,Kohjiro Ueki,Takashi Kadowaki +37 more
TL;DR: The results show that insulin signaling in endothelial cells plays a pivotal role in the regulation of glucose uptake by skeletal muscle, and improving endothelial insulin signaling may serve as a therapeutic strategy for ameliorating skeletal muscle insulin resistance.
Journal ArticleDOI
Pioglitazone Ameliorates Insulin Resistance and Diabetes by Both Adiponectin-dependent and -independent Pathways
Naoto Kubota,Yasuo Terauchi,Tetsuya Kubota,Hiroki Kumagai,Shinsuke Itoh,Hidemi Satoh,Wataru Yano,Hitomi Ogata,Kumpei Tokuyama,Iseki Takamoto,Tomoka Mineyama,Michiro Ishikawa,Masao Moroi,Kaoru Sugi,Toshimasa Yamauchi,Kohjiro Ueki,Kazuyuki Tobe,Tetsuo Noda,Tetsuo Noda,Ryozo Nagai,Takashi Kadowaki +20 more
TL;DR: In this article, pioglitazone-induced amelioration of insulin resistance and diabetes in ob/ob mice was attributed to decreased glucose production and increased AMP-activated protein kinase in the liver but not to increased glucose uptake in skeletal muscle.
Journal ArticleDOI
Insulin receptor substrate 2 plays a crucial role in β cells and the hypothalamus
Naoto Kubota,Yasuo Terauchi,Kazuyuki Tobe,Wataru Yano,Ryo Suzuki,Kohjiro Ueki,Iseki Takamoto,Hidemi Satoh,Toshiyuki Maki,Tetsuya Kubota,Masao Moroi,Miki Okada-Iwabu,Osamu Ezaki,Ryozo Nagai,Yoichi Ueta,Takashi Kadowaki,Tetsuo Noda +16 more
TL;DR: It is concluded that, in beta cells and the hypothalamus, Irs2 is crucially involved in the regulation of beta cell mass and leptin sensitivity.