Journal ArticleDOI
Adhesion of Candida albicans to mouse intestinal mucosa in vitro: development of the assay and test of inhibitors
Esther Segal,Dwayne C. Savage +1 more
TLDR
This study describes an in-vitro assay for estimating numbers of Candida albicans adherent to mouse intestinal mucosa and found that chitin soluble extracts inhibited adhesion of the yeasts to duodenal tissue by 48% and 43%, respectively.Abstract:
This study describes an in-vitro assay for estimating numbers of Candida albicans adherent to mouse intestinal mucosa No significant differences were observed in the capacity of C albicans to adhere to genetically distinct mouse strains nor in the binding ability of three C albicans strains Chitin soluble extracts, prepared from chitin isolated from C albicans or from chitin obtained commercially, inhibited adhesion of the yeasts to duodenal tissue by 48% and 43%, respectivelyread more
Citations
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Journal ArticleDOI
Adherence and receptor relationships of Candida albicans.
TL;DR: It is shown that mutants lacking CR3 activity are less adherent in vitro and, in fact, less virulent, and that the ligand recognized by the CR3 receptor (C3bi) as well as anti-CR3 antibodies blocks adherence of the organism to endothelial cells.
Book ChapterDOI
Adhesion and association mechanisms of Candida albicans.
TL;DR: In patients who are compromised immunologically and undergoing prolonged antimicrobic therapy, C. albicans can reach high numbers in the GI tract and, subsequently, pass through the intestinal mucosa to initiate systemic infection by the hematogenous route.
Journal ArticleDOI
The vaginal mycobiome: A contemporary perspective on fungi in women's health and diseases.
L. Latey Bradford,Jacques Ravel +1 more
TL;DR: The vaginal mycobiome has become an emerging field of study as genomics tools are increasingly employed and the authors begin to appreciate the role these fungal communities play in human health and disease.
Journal ArticleDOI
In vitro inhibition of adhesion of Candida albicans clinical isolates to human buccal epithelial cells by Fuc alpha 1----2Gal beta-bearing complex carbohydrates.
TL;DR: Total adhesion inhibitions were never obtained in the present experiments, suggesting that H disaccharide-bearing cell surface glycoconjugates could act as host receptors for C. albicans on human buccal epithelial cells as a part of a mechanism involving multireceptor specificities.
Journal ArticleDOI
Gastrointestinal colonization and systemic dissemination by Candida albicans and Candida tropicalis in intact and immunocompromised mice.
TL;DR: The data indicate that C. tropicalis appears to be more virulent than C. albicans and that factors responsible for gastrointestinal colonization, systemic dissemination, and mortality in immunocompromised mice may not be identical.
References
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Book
Candida and candidosis
TL;DR: A comprehensive and critical review of the medical and scientific literature on Candida infections by a leading authority in the field.
Journal ArticleDOI
Fungaemia and funguria after oral administration of Candida albicans.
W. Krause,H. Matheis,K. Wulf +2 more
TL;DR: It seems likely that antibiotic-induced fungal overpopulation may also result in fungaemia, since the population of C. albicans in the intestine was comparable to that sometimes seen after the use of broad-spectrum antibiotics.
Journal ArticleDOI
Chitin synthesis in Candida albicans: comparison of yeast and hyphal forms.
TL;DR: Chitin synthesis was studied in both yeast and hyphae of the dimorphic fungus Candida albicans, and enzyme activity was found to be located on the inner side of the plasma membrane.
Journal ArticleDOI
Immune Responses to Candida albicans in Genetically Distinct Mice
TL;DR: It is suggested that genetic control of acquired resistance to C. albicans may not be associated with the H-2 complex and resistance to systemic candidiasis is dependent upon a combination of innate factors, predominately an intact complement system, and the acquisition of an immune response, most likely of a cell-mediated type.
Journal ArticleDOI
Effect of various antibiotics on gastrointestinal colonization and dissemination by Candida albicans
Michael J. Kennedy,Paul A. Volz +1 more
TL;DR: It is suggested that the strictly anaerobic bacterial populations which predominate in the gut ecosystem are responsible for the inhibition of C. albicans adhesion, colonization and dissemination from the GI tract.
Related Papers (5)
Adherence of Candida albicans and other Candida species to mucosal epithelial cells.
R D King,J C Lee,A L Morris +2 more