Journal ArticleDOI
Administration of growth hormone to patients with advanced cardiac heart failure: effects upon left ventricular function, exercise capacity, and neurohormonal status.
Mónica Acevedo,Ramón Corbalán,Gastón Chamorro,Jorge E. Jalil,Carolina Nazzal,Claudia Campusano,Pablo Castro +6 more
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TLDR
Although the administration of growth hormone to patients with advanced cardiac heart failure was associated with a significant increase in insulin growth factor-1, there were no significant changes in ejection fraction, exercise capacity and/or neurohormonal status.About:
This article is published in International Journal of Cardiology.The article was published on 2003-02-01. It has received 47 citations till now. The article focuses on the topics: Growth hormone treatment & Ejection fraction.read more
Citations
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Journal ArticleDOI
Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease
TL;DR: Pulmonary rehabilitation, a multidisciplinary and structured intervention for patients with chronic pulmonary diseases, has been shown to improve exercise tolerance, reduce dyspnea and improve health-related quality of life.
Journal ArticleDOI
GH and the cardiovascular system: an update on a topic at heart.
TL;DR: The status of the GH/IGF-I system in relation to heart failure and the potential of GH as a therapeutic tool in the treatment of heart failure are reviewed.
Journal ArticleDOI
Exercise intolerance in chronic heart failure--skeletal muscle dysfunction and potential therapies
TL;DR: Considering the significance of peripheral muscle abnormalities and their development might help physicians and researchers better understand the mechanisms of well-established exercise training and pharmacological therapies that have been shown to improve the prognosis for CHF, and thus develop potential novel therapies.
Journal ArticleDOI
The GH/IGF-1 Axis and Heart Failure
TL;DR: It is believed that more clinical and experimental studies are necessary to exactly understand the mechanisms that determine the variable sensitivity to GH and its positive effects in the failing heart.
Journal ArticleDOI
Cardiac Effects of Growth Hormone Treatment in Chronic Heart Failure: A Meta-Analysis
Philippe Le Corvoisier,Luc Hittinger,Luc Hittinger,Philippe Chanson,Olivier Montagne,Isabelle Macquin-Mavier,Patrick Maison,Patrick Maison +7 more
TL;DR: The meta-analysis suggests that GH treatment improves several relevant cardiovascular parameters in patients with CHF, however, these results must be confirmed by a large randomized placebo-controlled trial on hemodynamic, morphological, and functional parameters during long-term high-dose GH treatment of patients withCHF.
References
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Journal ArticleDOI
Effects of enalapril on mortality in severe congestive heart failure: Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS)
Karl Swedberg,John Kjekshus +1 more
TL;DR: The addition of enalapril to conventional therapy in patients with severe congestive heart failure can reduce mortality and improve symptoms, and the effect seems to be due to a reduction in death from progression of heart failure.
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Randomised trial of losartan versus captopril in patients over 65 with heart failure (Evaluation of Losartan in the Elderly Study, ELITE)
Bertram Pitt,Robert Segal,Felipe Martinez,Georg Meurers,Alan J. Cowley,Ignatius Thomas,Prakash Deedwania,Dawn E Ney,Duane B. Snavely,Paul I Chang +9 more
TL;DR: Treatment with losartan was associated with an unexpected lower mortality than that found with captopril in older heart-failure patients and there was no difference in renal dysfunction.
Journal ArticleDOI
The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency
TL;DR: It is concluded that growth hormone has a role in the regulation of body composition in adults, probably through its anabolic and lipolytic actions.
Journal ArticleDOI
Hormonal Changes and Catabolic/Anabolic Imbalance in Chronic Heart Failure and Their Importance for Cardiac Cachexia
Stefan D. Anker,T. P. Chua,Piotr Ponikowski,Derek Harrington,Jon W. Swan,Wolfgang J. Kox,Philip A. Poole-Wilson,Andrew J.S. Coats +7 more
TL;DR: It is suggested that the syndrome of heart failure progresses to cardiac cachexia if the normal metabolic balance between catabolism and anabolism is altered.
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Growth hormone and the heart.
TL;DR: Evidence from laboratory models shows that GH induces mRNA expression for specific contractile proteins and myocyte hypertrophy, which provides plausible explanations for the cardiac abnormalities observed in clinical settings of excessive or defective GH production and support a role of GH in the maintenance of a normal cardiac structure and performance.