GH and the cardiovascular system: an update on a topic at heart.
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TLDR
The status of the GH/IGF-I system in relation to heart failure and the potential of GH as a therapeutic tool in the treatment of heart failure are reviewed.Abstract:
In this review, the importance of growth hormone (GH) for the maintenance of normal cardiac function in adult life is discussed. Physiological effects of GH and underlying mechanisms for interactions between GH and insulin-like growth factor I (IGF-I) and the cardiovascular system are covered as well as the cardiac dysfunction caused both by GH excess (acromegaly) and by GH deficiency in adult hypopituitary patients. In both acromegaly and adult GH deficiency, there is also increased cardiovascular morbidity and mortality possibly linked to aberrations in GH status. Finally, the status of the GH/IGF-I system in relation to heart failure and the potential of GH as a therapeutic tool in the treatment of heart failure are reviewed in this article.read more
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Journal ArticleDOI
Current Diagnostic and Treatment Strategies for Specific Dilated Cardiomyopathies: A Scientific Statement From the American Heart Association.
Biykem Bozkurt,Monica Colvin,Jennifer L. Cook,Leslie T. Cooper,Anita Deswal,Gregg C. Fonarow,Gary S. Francis,Daniel J. Lenihan,Eldrin F. Lewis,Dennis M. McNamara,Elfriede Pahl,Ramachandran S. Vasan,Kumudha Ramasubbu,Kismet Rasmusson,Jeffrey A. Towbin,Clyde W. Yancy +15 more
TL;DR: The intent of this American Heart Association (AHA) scientific statement is to summarize the current understanding of dilated cardiomyopathies, with special emphasis on recent developments in diagnostic approaches and therapies for specific cardiologyopathies.
Journal ArticleDOI
Systemic Complications of Acromegaly and the Impact of the Current Treatment Landscape: An Update.
TL;DR: Incidence of mortality, its correlation with GH, and IGF-I levels and the shift in the main cause of mortality in patients with acromegaly are addressed and the effects of different acromEGaly treatment options on these complications are detailed.
Journal ArticleDOI
Multiple Effects of Growth Hormone in the Body: Is it Really the Hormone for Growth?
TL;DR: It is proposed that GH may be a prohormone, rather than a hormone, since in many tissues and organs, it is proteolytically cleaved in a tissue-specific manner giving origin to shorter GH forms whose activity is still unknown.
Journal ArticleDOI
Cardioprotective effect of ghrelin against myocardial infarction-induced left ventricular injury via inhibition of SOCS3 and activation of JAK2/STAT3 signaling.
Refaat A. Eid,Mahmoud A. Alkhateeb,Samy M Eleawa,Fahaid Al-Hashem,Mubarak Al-Shraim,Attalla F. El-kott,Mohamed Samir Ahmed Zaki,Mohammad A. Dallak,Hussain Aldera +8 more
TL;DR: The cardioprotective effect of ghrelin against MI-induced LV injury is exerted via activation of JAK2/STAT3 signaling and inhibition of STAT1 signaling, independent of the GF/IGF-1 axis.
Journal ArticleDOI
Growth Hormone (GH) and Cardiovascular System.
TL;DR: It is postulate that short-term GH administration could be useful to treat cardiovascular diseases.
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Matrix Metalloproteinase Inhibition After Myocardial Infarction A New Approach to Prevent Heart Failure
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