Journal ArticleDOI
Aging and cancer.
Reads0
Chats0
TLDR
Physicians and oncologists need to be prepared for the projected increase of cancer in older persons and a new subspecialty is evolving: geriatric oncology.Abstract:
The world's population is aging. Older age is associated with an increase in the incidence of cancer, especially cancer of the breast, lung, prostate, and colon. The management of older patients with cancer is biased by the simple fact of their chronologic age. Underscreening, understaging, less aggressive therapy, lack of participation in clinical trials, or no treatment at all reflect this bias. Although an age-related reduction in the physiologic function of many organs occurs with age, these are not contraindications to treatment with surgery, radiation therapy, or chemotherapy. Chronologic age alone should not be used as a guide for cancer management. Rather, physiologic function or existence of comorbid conditions should be major factors in determining treatment. As a result of the impending need for improved cancer management in older persons, a new subspecialty is evolving: geriatric oncology. This field stresses an important interaction between geriatricians and oncologists, development of research directed at the problems of cancer in older persons, and education at all levels with respect to cancer prevention, cancer detection, and cancer therapy. Physicians and oncologists need to be prepared for the projected increase of cancer in older persons.read more
Citations
More filters
Journal ArticleDOI
The effect of cancer on the labor supply of employed men over the age of 65.
TL;DR: It is shown that cancer has a significant negative effect on the labor supply of employed men over the age of 65, and respondents who are diagnosed with cancer work 3 fewer hours per week than their non‐cancer counterparts.
Journal ArticleDOI
Integrating geriatrics and oncology.
TL;DR: This comprehensive review of the problems of aging and cancer provided encouragement to representatives of both disciplines to stimulate further research and clinical training relating to the problems in older persons and cancer.
Journal Article
Non-Hodgkin's lymphoma in the elderly. Part 1: Overview and treatment of follicular lymphoma.
TL;DR: The disease incidence and treatment approaches for both follicular and diffuse aggressive histologies in elderly patients are reviewed, as well as the impact of aging on the care of these patients.
DNA damage in canine transmissible venereal tumor cells
Anne Santos do Amaral,Isabelle Ferreira,Marcia Moleta Colodel,Dayse Maria Fávero Salvadore,Noeme Sousa Rocha +4 more
TL;DR: Investigation of the level of DNA damage in the three TVT cell types aiming a better understanding of mechanisms related to the aggressiveness of this neoplasia found higher level ofDNA damage was detected in lymphocytoid TVT cells when compared to the other two types.
Journal ArticleDOI
Multi-dimensional computational pipeline for large-scale deep screening of compound effect assessment: an in silico case study on ageing-related compounds.
Vipul Gupta,Alina Crudu,Yukiko Matsuoka,Samik Ghosh,Roger Rozot,Xavier Marat,Sibylle Jäger,Hiroaki Kitano,Lionel Breton +8 more
TL;DR: An international team of researchers led by Lionel Breton and Hiroaki Kitano proposed an innovative multi-dimensional computation pipeline for large-scale assessment of chemical compounds that harnesses the benefits of both structural and network biology together to cluster chemicals on their network effects across pathways and molecular interaction maps.
References
More filters
Journal ArticleDOI
Aging, natural death, and the compression of morbidity.
TL;DR: The average age at first infirmity can be raised, thereby making the morbidity curve more rectangular, and present data allow calculation of the ideal average life span, approximately 85 years.
Journal ArticleDOI
Health Care of the Elderly
TL;DR: The special considerations important to the proper evaluation of elderly patients are discussed, some current controversies in the field are highlighted, and recent progress in the management of several common clinical problems in the elderly are reviewed.
Journal ArticleDOI
Relationship between age at diagnosis and treatments received by cancer patients.
Vincent Mor,Susan Masterson-Allen,Richard J. Goldberg,Francis J. Cummings,Arvin S. Glicksman,Marsha D. Fretwell +5 more
TL;DR: Logistic regression analyses of subsamples of breast, lung, and colorectal cancer patients indicate that age is significantly inversely related to receipt of both subsequent chemotherapy and radiation therapy, controlling for stage of disease and presence of co‐morbid disease.
Journal ArticleDOI
Ovarian cancer in the elderly: an analysis of Surveillance, Epidemiology, and End Results Program data.
TL;DR: Aspects of ovarian cancer as it pertains especially to elderly women (those 65 years or older) are examined according to age/stage relationships at initial diagnosis and age variations in treatment and survival.
Journal ArticleDOI
Full dose versus attenuated dose daunorubicin, cytosine arabinoside, and 6-thioguanine in the treatment of acute nonlymphocytic leukemia in the elderly.
TL;DR: Attenuated chemotherapy with lower doses of DAT is the preferred induction regimen for elderly patients with acute nonlymphocytic leukemia since it causes fewer early deaths, allows a better quality of life, and yields survival times as durable as intensive therapy.