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Journal ArticleDOI

Aging and cancer.

B J Kennedy
- 01 Dec 1988 - 
- Vol. 6, Iss: 12, pp 1903-1911
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TLDR
Physicians and oncologists need to be prepared for the projected increase of cancer in older persons and a new subspecialty is evolving: geriatric oncology.
Abstract
The world's population is aging. Older age is associated with an increase in the incidence of cancer, especially cancer of the breast, lung, prostate, and colon. The management of older patients with cancer is biased by the simple fact of their chronologic age. Underscreening, understaging, less aggressive therapy, lack of participation in clinical trials, or no treatment at all reflect this bias. Although an age-related reduction in the physiologic function of many organs occurs with age, these are not contraindications to treatment with surgery, radiation therapy, or chemotherapy. Chronologic age alone should not be used as a guide for cancer management. Rather, physiologic function or existence of comorbid conditions should be major factors in determining treatment. As a result of the impending need for improved cancer management in older persons, a new subspecialty is evolving: geriatric oncology. This field stresses an important interaction between geriatricians and oncologists, development of research directed at the problems of cancer in older persons, and education at all levels with respect to cancer prevention, cancer detection, and cancer therapy. Physicians and oncologists need to be prepared for the projected increase of cancer in older persons.

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Citations
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Issues of Aging and Geriatric Medicine: Relevance to Cancer Treatment and Hematopoietic Reconstitution

TL;DR: With appropriate pretreatment assessment of organ reserve, physical performance, and cognitive function, individualized (tailored) therapy may ultimately prove to offer the greatest chance for successful outcomes.
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Patterns-of-Care Analysis for Radiotherapy of Elderly Head-and-Neck Cancer Patients: A Trinational Survey in Germany, Austria and Switzerland

TL;DR: Treatment of elderly HNSCC-patients in the German-speaking countries mainly follows guidelines established for younger patients, and algorithms for patient stratification and treatment de-escalation for “unfit” elderly patients are needed.
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Geriatric oncology and clinical trials.

TL;DR: For future clinical trials to be truly meaningful they need to appropriately assess and incorporate the needs of the majority of the cancer population, including changing eligibility criteria to make them less restrictive by accounting for multiple comorbidities and prior malignancy.
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Nuclear Transglutaminase 2 interacts with topoisomerase II⍺ to promote DNA damage repair in lung cancer cells

TL;DR: Wang et al. as discussed by the authors discovered that Transglutaminase 2 (TG2) acted as a new component of DSB repair complex, which increased sensitivity in lung cancer cells and engrafted lung cancers.
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Rising to the medication's requirements: The experience of elderly cancer patients receiving palliative chemotherapy in the elective oncogeriatrics field.

TL;DR: Following an anthropological critical interpretative approach focusing on practical and symbolic effects of chemotherapy in a rapidly evolving medical field, 20 semi-structured interviews and observations of medicine storage places at home among elderly cancer patients aged 70 and over in a clearly incurable situation receiving palliative chemotherapy are conducted.
References
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Journal ArticleDOI

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TL;DR: The average age at first infirmity can be raised, thereby making the morbidity curve more rectangular, and present data allow calculation of the ideal average life span, approximately 85 years.
Journal ArticleDOI

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Journal ArticleDOI

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TL;DR: Logistic regression analyses of subsamples of breast, lung, and colorectal cancer patients indicate that age is significantly inversely related to receipt of both subsequent chemotherapy and radiation therapy, controlling for stage of disease and presence of co‐morbid disease.
Journal ArticleDOI

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TL;DR: Aspects of ovarian cancer as it pertains especially to elderly women (those 65 years or older) are examined according to age/stage relationships at initial diagnosis and age variations in treatment and survival.
Journal ArticleDOI

Full dose versus attenuated dose daunorubicin, cytosine arabinoside, and 6-thioguanine in the treatment of acute nonlymphocytic leukemia in the elderly.

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