Journal ArticleDOI
Airway responsiveness in young black and white women.
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After adjusting for selective demographic and smoking differences, a significant additional effect of race on mean PD20 was found, however, after adjustment for level of serum IgE and level of FEV1, racial differences were no longer apparent.Abstract:
The prevalence and severity of asthma appears to be greater in blacks than in whites. To determine if racial differences in airway responsiveness may explain these findings, methacholine challenge tests from 62 black and 238 white women 20 to 35 yr of age were evaluated. Subjects served as controls for a case-control study of the relation of airway responsiveness and preterm labor. Standardized questionnaires were used to obtain information on age, obstetrical history, education, income, cigarette smoking, medication use, and respiratory illnesses and symptoms. Total serum IgE was measured using a radioimmunoassay. Methacholine challenge testing was performed on all subjects 6 wk after delivery, and the provocative dose causing a 20% decrease in FEV1 (PD20) was calculated. Black women in the study had more pregnancies and children, were younger, less well educated and more impoverished, and reported greater cigarette smoking and less medication use than did the white women. Additionally, black women had h...read more
Citations
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Journal ArticleDOI
Race, socioeconomic factors, and area of residence are associated with asthma prevalence.
TL;DR: Investigation of the effect of SES on the relationship between race/ethnicity and asthma prevalence in a cohort of families with a history of asthma or allergies from the Boston, Massachusetts area found that Blacks and Hispanics are higher in SES than other minority groups.
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Respiratory symptoms and bronchial responsiveness in lifeguards exposed to nitrogen trichloride in indoor swimming pools.
TL;DR: The data show that lifeguards exposed to NCl3 in indoor swimming pools are at risk of developing irritant eye, nasal, and throat symptoms and exposure to N Cl3 does not seem to carry therisk of developing permanent bronchial hyperresponsiveness.
Journal ArticleDOI
Prevalence and treatment of chronic airways obstruction in adults over the age of 45.
D. S. Renwick,Martin J. Connolly +1 more
TL;DR: Investigating the possibility that older adults with obstructive airways disease frequently do not receive appropriate treatment in central Manchester found chronic airways obstruction is very common in adults in this inner city population, but is frequently overlooked.
Journal ArticleDOI
Exposure to cockroach allergen in the home is associated with incident doctor-diagnosed asthma and recurrent wheezing.
TL;DR: Exposure to cockroach allergen early in life may contribute to the development of asthma in susceptible children and neither dust mite nor catAllergen levels were significantly associated with either outcome.
Journal ArticleDOI
Ethnic differences in asthma and associated phenotypes: Collaborative Study on the Genetics of Asthma
Lucille A. Lester,Stephen S. Rich,Malcolm N. Blumenthal,Alkis Togias,Shirley Murphy,Floyd J. Malveaux,Michael E. Miller,Georgia M. Dunston,Julian Solway,Raoul L. Wolf,Jonathan M. Samet,David G. Marsh,Deborah A. Meyers,Carole Ober,Eugene R. Bleecker +14 more
TL;DR: Clinical differences observed in asthma and allergic characteristics among African American, white, and Hispanic family members could be due to differences in genetic susceptibility among the ethnic groups, such as those suggested by the previous genome screen.
References
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Journal ArticleDOI
Relation between airway responsiveness and serum IgE in children with asthma and in apparently normal children.
TL;DR: Even in children who have been asymptomatic throughout their lives and have no history of atopic disease, airway hyperresponsiveness appears to be closely linked to an allergic diathesis, as reflected by the serum total IgE level.
Journal ArticleDOI
Analysis of dose-response curves to methacholine. An approach suitable for population studies.
TL;DR: Dose-response slope is proposed as a quantitative measure of nonspecific airway responsiveness that avoids censoring and that may be particularly useful in epidemiologic studies.
Journal ArticleDOI
Growth and decay of pulmonary function in healthy blacks and whites
TL;DR: Maximum expiratory flow-volume curves are recorded in 3046 healthy persons, blacks and whites, age 7 and over--a representative population of lifetime nonsmokers except for some black adult males, who were healthy smokers or ex-smokers.
Journal ArticleDOI
Poverty, race, and hospitalization for childhood asthma.
TL;DR: It is concluded that Black children are at increased risk of hospitalization for asthma, but that some or all of this increase is related to poverty rather than to race.
Journal ArticleDOI
Racial, Social, and Environmental Risks for Childhood Asthma
TL;DR: It is concluded that black and poor children in the United States do have higher rates of asthma, that social and environmental factors exert substantial influences on rates of Asthma, and that much of the racial and economic disparity in prevalence can be accounted for by a variety ofsocial and environmental characteristics.