Journal ArticleDOI
Aldehyde dehydrogenase gene superfamily: the 2000 update
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TLDR
A complete list of all ALDH sequences known to date is presented here along with the evolution analysis of the eukaryotic ALDHs.About:
This article is published in Chemico-Biological Interactions.The article was published on 2001-01-30. It has received 82 citations till now. The article focuses on the topics: Aldehyde dehydrogenase & Genome.read more
Citations
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Journal ArticleDOI
Role of aldehyde dehydrogenases in endogenous and xenobiotic metabolism.
TL;DR: This review summarizes the ALDHs with an emphasis on catalytic properties and xenobiotic substrates of these enzymes.
Journal ArticleDOI
Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family
TL;DR: Analysis of the aldehyde dehydrogenase (ALDH) gene superfamily showed that the human genome contains 19 putatively functional genes and three pseudogenes, and the ALDH gene products appear to be multifunctional proteins, possessing both catalytic and non-catalytic properties.
Journal ArticleDOI
Aldehyde dehydrogenase gene superfamily: the 2002 update.
TL;DR: A complete listing of all ALDH sequences known to date, along with the evolutionary analysis of the eukaryotic ALDHs are presented.
Journal ArticleDOI
Update on the aldehyde dehydrogenase gene (ALDH) superfamily
Brian C. Jackson,Chad Brocker,David C. Thompson,William Black,Konstandinos Vasiliou,Daniel W. Nebert,Vasilis Vasiliou +6 more
TL;DR: The update of ALDH genes in several recently sequenced vertebrates is provided and the associated records found in the National Center for Biotechnology Information (NCBI) gene database are clarified, highlighting where and when likely gene-duplication and gene-loss events have occurred.
Journal ArticleDOI
Role of human aldehyde dehydrogenases in endobiotic and xenobiotic metabolism
TL;DR: The human genome contains at least 17 genes that are members of the aldehyde dehydrogenase (ALDH) superfamily, enzymes that oxidize a wide range of aldehydes to their corresponding carboxylic acids.
References
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Journal ArticleDOI
A genomic perspective on protein families
TL;DR: Comparison of proteins encoded in seven complete genomes from five major phylogenetic lineages and elucidation of consistent patterns of sequence similarities allowed the delineation of 720 clusters of orthologous groups (COGs), which comprise a framework for functional and evolutionary genome analysis.
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Pfam 3.1: 1313 multiple alignments and profile HMMs match the majority of proteins
TL;DR: Pfam is a collection of multiple alignments and profile hidden Markov models of protein domain families that contains 1313 families and over 54% of proteins in SWISS-PROT-35 and SP-TrEMBL-5 match a Pfam family.
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Human aldehyde dehydrogenase gene family
TL;DR: The phylogenic tree constructed of 56 ALDH sequences of humans, animals, fungi, protozoa and eubacteria, suggests that the present-day human ALDH genes were derived from four ancestral genes that existed prior to the divergence of Eubacteria and Eukaryotes.
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Aldehyde Dehydrogenases and Their Role in Carcinogenesis
TL;DR: This work suggests that modulation of ALDH activity may an important determinant of the effectiveness of certain chemotherapeutic agents and what is currently known about the general structural and functional properties of the enzymes and the interrelationships of the various forms.
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Relationships within the aldehyde dehydrogenase extended family.
TL;DR: Phylogenetic analysis of these aldehyde dehydrogenase‐related sequences indicates at least 13 ALDH families, most of which have previously been identified but not grouped separately by alignment, which cluster into seven sequence motifs conserved in almost all ALDHs.