Allergic identification for ginkgo kernel protein in guinea pigs.
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TLDR
The present results may indicate that gingko kernel protein has an allergenic capacity.Abstract:
Ginkgo biloba L. can cause allergic reactions when consumed. In this paper, an allergy test to guinea pig was investigated. Guinea pigs were sensitized with 50 mg/mL of ginkgo kernel protein orally on days 1, 3, and 5, and intraperitoneally challenged with 100mg/mL of the protein on day 7 after the last sensitization. The volume of sensitization and challenge was 0.20mL/100 g weight. The results showed the average allergy grade for guinea pigs reached four and the allergy rate was 100%. The immunoglobulin G and E levels in sera were significantly higher than those in the controls. Footpads swelled distinctly, and the passive cutaneous allergy test manifested a positive response. There were inflammatory changes in the lungs and intestines. In conclusion, the present results may indicate that gingko kernel protein has an allergenic capacity.read more
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Modification of structure and functionalities of ginkgo seed proteins by pH-shifting treatment.
TL;DR: In this article, the effects of pH-shifting treatments on the structural and functional properties of ginkgo seed protein isolate (GSPI) were investigated, and the pH 2.0-treatment significantly increased the surface hydrophobicity of GSPI and significantly improved the emulsifying activity.
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A critical review of current technologies used to reduce ginkgotoxin, ginkgotoxin-5’-glucoside, ginkgolic acid, allergic glycoprotein, and cyanide in Ginkgo biloba L. seed
TL;DR: In this paper , a review focused on the technologies that have been used to minimize toxins in Ginkgo biloba seed (GBS) and a comparison of these techniques was made based on their benefits, drawbacks, feasibility, pharmacological activities, and future direction or opportunities to improve current ones were provided.
Journal ArticleDOI
A critical review of current technologies used to reduce ginkgotoxin, ginkgotoxin-5'-glucoside, ginkgolic acid, allergic glycoprotein, and cyanide in Ginkgo biloba L. seed.
TL;DR: In this article , a review focused on the technologies that have been used to minimize toxins in Ginkgo biloba seed (GBS) and a comparison of these techniques was made based on their benefits, drawbacks, feasibility, pharmacological activities, and future direction or opportunities to improve current ones were provided.
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An LC-MS-based metabolomic approach provides insights into the metabolite profiles of Ginkgo biloba L. at different developmental stages and in various organs.
TL;DR: In this paper , a comprehensive and systematic untargeted LC-MS metabolomics analysis of the metabolites in ginkgo leaves and seeds at two developmental stages identified 8146 known metabolites, which mainly included lipids and lipid-like molecules, phenylpropanoids and polyketides, organoheterocyclic compounds, organic acids and derivatives, organic oxygen compounds, and benzenoids.
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<i>Ginkgo biloba</i>: A Potential Anti-Cancer Agent
TL;DR: Ginkgo biloba is a living fossil plant, which has been used in record by over 5,000 years as mentioned in this paper , and it is generally considered as safe herbal extract in clinical application.
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In vitro evaluation of the cytotoxic potential of alkylphenols from Ginkgo biloba L.
TL;DR: Electron microscopic analysis of HaCaT cells revealed a drug induced formation of myelinosomes possibly due to the inhibition of lysosomal enzymes, while morphological evaluation of LLC-MK(2) cells indicated that the cytotoxic activity of GA in these cells is primarily mediated by transformation of mitochondria, which is probably induced by uncoupling of oxidative phosphorylation.
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Ginkgolic acids induce neuronal death and activate protein phosphatase type-2C
TL;DR: Ginkgolic acids-induced death showed features of apoptosis as the authors observed chromatin condensation, shrinkage of the nucleus and reduction of the damage by the protein synthesis inhibitor cycloheximide, demonstrating an active type of cell death.