Allometric scaling of M-mode cardiac measurements in normal adult dogs.
Craig C. Cornell,Mark D Kittleson,Paul Della Torre,Jens Häggström,Christophe W. Lombard,Henrik D. Pedersen,Andrea Vollmar,Aaron C. Wey +7 more
TLDR
The equations developed from this study appear to be applicable to adult dogs of most breeds, and appropriate mean values and prediction intervals were calculated for normal dogs, allowing veterinarians to correctly and appropriately index M-mode values.Abstract:
Indices for M-mode measurements in dogs usually have been based on the assumption that a linear relationship exists between these measurements and body weight (BW) or body surface area (BSA). The relationships between the geometry of 3-dimensional objects do not support this assumption. The purposes of this study were to retrospectively examine M-mode data from a large number of dogs of varying sizes and breeds that were examined by a large number of ultrasonographers, to use the allometric equation to determine the appropriate BW exponent required to predict these cardiac dimensions, and to determine normal mean values and prediction intervals for common M-mode variables. Linear regression analyses of data from 494 dogs (2.2-95 kg) revealed a good correlation between M-mode measurements and BW after logarithmic transformation of the data (r2 = .55-.88). Most variables were most closely related to an index of body length, BW(1/3), although the exponent that best predicted diastolic and systolic left ventricular wall thicknesses was closer to 0.25. No variable indexed well to BW or BSA. With these data, appropriate mean values and prediction intervals were calculated for normal dogs, allowing veterinarians to correctly and appropriately index M-mode values. The equations developed from this study appear to be applicable to adult dogs of most breeds.read more
Citations
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Journal ArticleDOI
Does Size Matter? Clinical Applications of Scaling Cardiac Size and Function for Body Size
TL;DR: The critical role of body size measurements in cardiovascular medicine is described and the experimental evidence, theoretical basis, and clinical application of scaling of various functional parameters are presented.
Journal ArticleDOI
ACVIM consensus guidelines for the diagnosis and treatment of myxomatous mitral valve disease in dogs.
Bruce W. Keene,Clarke E. Atkins,John D. Bonagura,John D. Bonagura,Philip R. Fox,Jens Häggström,Virginia Luis Fuentes,Mark A. Oyama,John E. Rush,Rebecca L. Stepien,Masami Uechi +10 more
TL;DR: In this paper, the authors present guidelines for the diagnosis and treatment of myxomatous mitral valve disease (MMVD), also known as endocardiosis and degenerative or chronic valvular heart disease in dogs.
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Effect of pimobendan or benazepril hydrochloride on survival times in dogs with congestive heart failure caused by naturally occurring myxomatous mitral valve disease: the QUEST study.
Jens Häggström,Adrian Boswood,Michael R. O'Grady,Olaf Jöns,Sarah Smith,Simon Swift,M. Borgarelli,B. Gavaghan,Jan-Gerd Kresken,M. Patteson,B. Åblad,Claudio Bussadori,Tony M. Glaus,A. Kovacevic,M. Rapp,Roberto A. Santilli,Anna Tidholm,A. Eriksson,M.C. Belanger,M. Deinert,C.J.L. Little,Clarence Kvart,Anne French,M. Ronn-Landbo,Gerhard Wess,A.V. Eggertsdottir,M.L. O'Sullivan,Matthias Schneider,Christophe W. Lombard,Joanna Dukes-McEwan,Ruth Willis,A. Louvet,Rocky DiFruscia +32 more
TL;DR: Pimobendan plus conventional therapy prolongs time to sudden death, euthanasia for cardiac reasons, or treatment failure in dogs with CHF caused by MMVD compared with benazeprilplus conventional therapy.
Journal ArticleDOI
Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study - A Randomized Clinical Trial
Adrian Boswood,Jens Häggström,Sonya G. Gordon,Gerhard Wess,Rebecca L. Stepien,Mark A. Oyama,Bruce W. Keene,John D. Bonagura,Kristin A. MacDonald,M. Patteson,Sarah Smith,Philip R. Fox,Karen Sanderson,Richard Woolley,Viktor Szatmári,Pierre Menaut,Whitney M. Church,M. L. O'Sullivan,J-P Jaudon,J-G Kresken,John E. Rush,Kirstie A. Barrett,Steven L. Rosenthal,Ashley B. Saunders,Ingrid Ljungvall,M. Deinert,Eric Bomassi,Amara H. Estrada,M. J. Fernández del Palacio,N.S. Moïse,Jonathan A. Abbott,Yoko Fujii,Alan W. Spier,Michael W. Luethy,Roberto A. Santilli,Masami Uechi,Anna Tidholm,P. Watson +37 more
TL;DR: Administration of pimobendan to dogs with MMVD and echocardiographic and radiographic evidence of cardiomegaly results in prolongation of preclinical period and is safe and well tolerated.
Journal ArticleDOI
Efficacy of Pimobendan in the prevention of congestive heart failure or sudden death in Doberman Pinschers with preclinical dilated cardiomyopathy (The PROTECT Study)
Nuala Summerfield,Adrian Boswood,Michael R. O'Grady,Sonya G. Gordon,Joanna Dukes-McEwan,Mark A. Oyama,Sarah Smith,M. Patteson,Anne French,Geoff Culshaw,L Braz-Ruivo,Amara H. Estrada,M. L. O'Sullivan,J. Loureiro,Ruth Willis,P. Watson +15 more
TL;DR: Administration of pimobendan to Dobermans with preclinical DCM prolongs the time to the onset of clinical signs and extends survival and treatment of dogs in the preclinical phase of this common cardiovascular disorder can lead to improved outcome.
References
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Journal ArticleDOI
Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements.
TL;DR: The survey shows significant interobserver and interlaboratory variation in measurement when examining the same echoes and indicates a need for ongoing education, quality control and standardization of measurement criteria.
Book
Scaling, why is animal size so important?
TL;DR: The importance of animal size in animal function is discussed in this paper, where it is shown that physical laws are equally important, for they determine rates of diffusion and heat transfer, transfer of force and momentum, strength of structures, the dynamics of locomotion, and other aspects of the functioning of animal bodies.
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