Altered functional loading causes differential effects in the subchondral bone and condylar cartilage in the temporomandibular joint from young mice
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TLDR
Altered functional TMJ loading in mice for 2-6 weeks leads to a loss of the condylar cartilage and a transient loss in the density of the mandibular condylars subchondral bone.About:
This article is published in Osteoarthritis and Cartilage.The article was published on 2009-03-01 and is currently open access. It has received 92 citations till now. The article focuses on the topics: Fibrocartilage & Cartilage.read more
Citations
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Enthesis fibrocartilage cells originate from a population of Hedgehog-responsive cells modulated by the loading environment.
TL;DR: The formation of a functional mineralized tendon enthesis, which links tendons to bones, involves Hedgehog-responsive cells and is modulated by muscle loading, demonstrate that Hh signaling within developing enthesis fibrocartilage cells is required for enthesis formation.
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Temporomandibular joint osteoarthritis: cone beam computed tomography findings, clinical features, and correlations.
TL;DR: Condylar erosion, flattening, osteophytes, pain, joint sounds, reduced jaw movements, and worsened mastication were common findings in TMJ-OA in the present study.
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Reducing dietary loading decreases mouse temporomandibular joint degradation induced by anterior crossbite prosthesis.
Liu Yifan,L.-F. Liao,Hongyun Zhang,Lei Lu,Kai Jiao,Mian Zhang,Jing Zhang,Jian-Jun He,Yaoping Wu,Di Chen,M. Wang +10 more
TL;DR: It is suggested that a lower level of functional loading by providing small-size diet could reduce TMJ degradation induced by the biomechanical stimulation from abnormal occlusion.
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Condylar volume and condylar area in class I, class II and class III young adult subjects
Matteo Saccucci,Michele D'Attilio,Daria Rodolfino,Felice Festa,Antonella Polimeni,Simona Tecco +5 more
TL;DR: Skeletal class appeared to be associated to the mandibular condylar volume and to theMandibular Condylar area in the Caucasian orthodontic population.
Journal ArticleDOI
Indian Hedgehog Roles in Post-natal TMJ Development and Organization
Takanaga Ochiai,Yoshihiro Shibukawa,M. Nagayama,Christina Mundy,Tadashi Yasuda,T. Okabe,K. Shimono,M. Kanyama,Hiromasa Hasegawa,Yukiko Maeda,Beate Lanske,Maurizio Pacifici,Eiki Koyama +12 more
TL;DR: Analysis of the data shows, for the first time, that continuous Ihh action is required for completion of post-natal TMJ growth and organization and that lubricin overexpression in mutants may represent a compensatory response to sustain TMJ movement and function.
References
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RANKL–RANK signaling in osteoclastogenesis and bone disease
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Epidemiology of Temporomandibular Disorders: Implications for the Investigation of Etiologic Factors
TL;DR: The available data highlight the need for further research on etiologic factors associated with temporomandibular pain and with specific diagnostic subtypes of temporom andibular disorders, which appear to be more prevalent in women than in men.
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PTHrP and skeletal development.
TL;DR: Parathyroid hormone‐related protein (PTHrP) participates in the regulation of endochondral bone development and actions to delay chondrocyte differentiation are mediated by the phosphorylation of the transcription factor, SOX9, and by suppression of synthesis of mRNA encoding the transcription factors, Runx2.
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Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP
Tatsuya Kobayashi,Desi W Soegiarto,Yingzi Yang,Beate Lanske,Ernestina Schipani,Andrew P. McMahon,Henry M. Kronenberg +6 more
TL;DR: It is demonstrated that Indian hedgehog acts on periarticular chondrocytes to stimulate their differentiation, thereby regulating the columnar cell mass independently of PTHrP.
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Cellular stages in cartilage formation as revealed by morphometry, radioautography and type II collagen immunostaining of the mandibular condyle from weanling rats.
TL;DR: The role played by cell addition, cell enlargement, and matrix deposition in the endochondral growth of the condyle was assessed in weanling rats by four approaches making use of the light microscope: morphometry, 3H-thymidine radioautographic,3H-proline radioautography, and immunostaining for the cartilage-specific type II collagen.
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