Journal ArticleDOI
Altered responsiveness of regional brain dopamine and DOPAC levels to systemic administration of quinpirole, a dopamine D2 agonist, in DOCA/NaCl-hypertensive rats.
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Quinpirole resulted in a significant increase in DA stores and decrease in DOPAC stores in most brain regions examined in both DOCA/NaCl-hypertensive rats and normotensive controls, presumably by inhibiting DA release through a presynaptic mechanism.About:
This article is published in Brain Research.The article was published on 1987-06-09. It has received 5 citations till now. The article focuses on the topics: Quinpirole & Dopaminergic.read more
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Effects of quinpirole on central dopamine systems in sensitized and non-sensitized rats
TL;DR: In this paper, post mortem changes in central dopaminergic terminal regions following acute or chronic treatment regimens with the dopamine D2/D3 receptor agonist quinpirole, a psychomotor stimulant which induces pronounced behavioural sensitization when given chronically.
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Effects of quinpirole on central dopamine systems in sensitized and non-sensitized rats 1 A prelimin
Journal ArticleDOI
ROLE OF HYPOTHALAMIC α2‐ADRENOCEPTOR ACTIVITY IN FRUCTOSE‐INDUCED HYPERTENSION
Marcos A. Mayer,Christian Höcht,Javier A.W. Opezzo,H.A. Peredo,Daniel Navacchia,Carlos A. Taira,Belisario E. Fernández,Ana María Puyó +7 more
TL;DR: The notion that α2‐adrenoceptor tone of the anterior hypothalamus ofnormotensive rats, which contributes to normal blood pressure regulation, is not involved in the control of HR in either normotensive C or hypertensive F rats is supported.
Journal ArticleDOI
Cardiovascular responses to intrathecal dopamine receptor agonists in conscious DOCA‐salt hypertensive rats
TL;DR: In conscious DOCA‐salt hypertensive rats, intrathecally‐injected apomorphine or quinpirole decreased MAP and or HR through a spinal D2 dopaminergic mechanism, as previously demonstrated in normotensive intact rats.
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[The role of Na+-K+ ATPase activity on blood pressure regulation and sodium metabolism in DOCA-treated rats].
Shuichi Shigetomi,Hideo Tosaki,Shuichi Ueno,Hiroshi Kohno,Kazuya Mori,Ken Katoh,Kiyonobu Tanaka,Hiroshi Haga,Shinji Kin,A Matsunaga +9 more
TL;DR: The results suggest that Na+-K+ ATPase may play an important role in the maintenance of blood pressure through sodium efflux and that ouabain, Na-potassium adenosine 5'-triphosphatase inhibitor, may change the renal sodium excretion and vascular responsiveness to endogenous pressor substances, leading to higher blood pressure after the administration of sodium and mineralocorticoid.
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Journal Article
Presynaptic regulation of the release of catecholamines.
TL;DR: Evidence has accumulated in favour of the view that, in addition to the classical postsynaptic adrenoceptors that mediate the responses of the effector organ, there are also receptors located on the noradrenergic nerve terminals that appear to be involved in the modulation of the release of dopamine and of epinephrine in the central nervous system.
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Central dopaminergic neurons: Effects of alterations in impulse flow on the accumulation of dihydroxyphenylacetic acid
TL;DR: It is concluded that short-term changes in brain levels of DOPAC appear to provide a useful index of alterations in the functional activity of central dopaminergic neurons.
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Widespread distribution of brain dopamine receptors evidenced with [125I]iodosulpride, a highly selective ligand.
TL;DR: The new benzamide derivative [125I]iodosulpride is a highly sensitive and selective ligand for D-2 dopamine receptors and displays a very low nonspecific binding to membrane or autoradiographic sections, suggesting larger physiological and pathophysiological roles for cerebral dopamine receptors than was previously thought.
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Resolution and absolute configuration of an ergoline-related dopamine agonist, trans-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H(or 2H)-pyrazolo[3,4-g]quinoline
Robert Daniel Titus,Kornfeld Edmund C,Noel D. Jones,James A. Clemens,E. B. Smalstig,Ray W. Fuller,Hahn Ra,Hynes,Norman R. Mason,David T.W. Wong,Foreman Mark Mortensen +10 more
TL;DR: Crystallographic analysis has proven that the absolute configuration of the active (-) isomer is the same as that of the natural ergolines.