Journal ArticleDOI
Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis
TLDR
The nucleus basalis of Meynert provides diffuse cholinergic input to the neocortex and loss of this neuronal population may represent an anatomical correlate of the well‐documented cholinerential derangement in Alzheimer disease.Abstract:
The nucleus basalis of Meynert provides diffuse cholinergic input to the neocortex. When compared with an age- and sex-matched control, the nucleus basalis from a patient with Alzheimer disease demonstrated substantial reduction of neurons. Loss of this neuronal population may represent an anatomical correlate of the well-documented cholinergic derangement in Alzheimer disease.read more
Citations
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Journal ArticleDOI
The Cholinergic Hypothesis of Geriatric Memory Dysfunction
Raymond T. Bartus,Raymond T. Bartus,Reginald L. Dean,Bernard Beer,Bernard Beer,Arnold S. Lippa,Arnold S. Lippa +6 more
TL;DR: Biochemical, electrophysiological, and pharmacological evidence supporting a role for cholinergic dysfunction in age-related memory disturbances is critically reviewed and an attempt has been made to identify pseudoissues, resolve certain controversies, and clarify misconceptions that have occurred in the literature.
Journal ArticleDOI
Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain.
Peter J. Whitehouse,Donald L. Price,Robert G. Struble,Arthur W. Clark,Joseph T. Coyle,Mahlon R. DeLong +5 more
TL;DR: Demonstration of selective degeneration of neurons of the nucleus basalis of Meynert represents the first documentation of a loss of a transmitter-specific neuronal population in a major disorder of higher cortical function and points to a critical subcortical lesion in Alzheimer's patients.
Journal ArticleDOI
Alzheimer's disease: a disorder of cortical cholinergic innervation
TL;DR: Advances in neurotransmitter systems involved in the symptomatic manifestations of neurological and psychiatric disorders reflect a close interaction between experimental and clinical neuroscientists in which information derived from basic neurobiology is rapidly utilized to analyze disorders of the human brain.
Journal ArticleDOI
Central cholinergic pathways in the rat: an overview based on an alternative nomenclature (Ch1-Ch6).
TL;DR: It appears that the age-related changes of memory function as well as some of the behavioral disturbances seen in the dementia of Alzheimer's Disease may be related to pathological alterations along central cholinergic pathways.
Journal ArticleDOI
Cholinergic innervation of cortex by the basal forebrain : cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (substantia innominata), and hypothalamus in the rhesus monkey
TL;DR: The organization of projections from the cholinergic neurons of the basal forebrain to neocortex and associated structures was investigated in the rhesus monkey with the help of horseradish peroxidase transport, acetyl‐cholinesterase histochemistry, and choline acetyltransferase immunohis‐tochemistry.
References
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Journal ArticleDOI
Selective loss of central cholinergic neurons in alzheimer's disease
Peter Davies,A.J.F. Maloney +1 more
Journal ArticleDOI
The ascending cholinergic reticular system: neocortical, olfactory and subcortical projections
C. C. D. Shute,P. R. Lewis +1 more
Journal ArticleDOI
Necropsy evidence of central cholinergic deficits in senile dementia.
Journal ArticleDOI
Dementia of the Alzheimer Type
R D Terry,P Davies +1 more
TL;DR: In recent years most investigators have agreed that it is essentially identical to the most common form of senile dementia, which is thus calledSenile dementia of the Alzheimer type, or SDAT, which was originally described as a presenile disor der occurring before age 65.
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Selective loss of central cholinergic neurons in alzheimer's disease
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