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Journal ArticleDOI

Amniotic fluid phospholipids in normal and abnormal pregnancy

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TLDR
A method is described that gives accurate quantification of the phospholipid fractions in amniotic fluid and requires a sample of only one ml, which is associated with the development of respiratory distress syndrome and also with anencephaly.
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This article is published in British Journal of Obstetrics and Gynaecology.The article was published on 1973-04-01. It has received 22 citations till now. The article focuses on the topics: Amniotic fluid & Phospholipid.

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Citations
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Journal ArticleDOI

The interpretation and significance of the lecithin-sphingomyelin ratio in amniotic fluid.

TL;DR: General principles of acetone precipitation are presented as a guide in clinical interpretation of the L/S ratio and evidence is presented that there is continuity between the fetal lungs and amniotic fluid.
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Surfactant proteins A (SP-A) and D (SP-D): Levels in human amniotic fluid and localization in the fetal membranes

TL;DR: Immunochemistry of paraffin sections of fetal membranes, revealed the presence of both SP-A and SP-D in the amniotic epithelium and chorio-decidual layers, and therefore they may play a role in the antibody-independent recognition and clearance of pathogens in theAmniotic fluid.
Journal Article

Surfactant proteins SP-A and SP-D in human health and disease.

TL;DR: The lung surfactant-associated hydrophilic proteins (SP-A and D) are collagen-containing C-type (calcium-dependent) lectins, called collectins, and are structurally similar to mannose-binding proteins of the complement system.
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Intravenous Labetalol and Intravenous Dihydralazine in Severe Hypertension in Pregnancy

TL;DR: Continuous infusion of labetalol appears to offer significant advantages in the management of severe hypertension in pregnancy and merits further trial.
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Methods of Evaluating Fetal Lung Maturity

TL;DR: It is now clear that most methods currently in use for assessing fetal lung maturity depend on the detection of a sudden release of surfactant into the amniotic fluid as the lung reaches a critical stage of maturity.
References
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Journal ArticleDOI

Phosphorus Assay in Column Chromatography

TL;DR: If the highest accuracy was not required, the following manipulations simplified and speeded multiple total phosphorus determinations on the eluates from column chromatographic separations.
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Clinical assessment of gestational age in the newborn infant

TL;DR: A scoring system for gestational age, based on 10 neurologic and 11 “external” criteria, has been applied to 167 newborn infants and gives consistent results within the first 5 days and is equally reliable in the first 24 hours of life.
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Diagnosis of the respiratory distress syndrome by amniocentesis

TL;DR: Studies on 302 amniocenteses show that changes in phospholipids in amniotic fluid reflect those in the lung of the developing fetus, and a sudden increase in lecithin concentration after 35 weeks heralds maturity of the pulmonary alveolar lining when respiratory distress syndrome will not occur should the fetus then be born.
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Assessment of the risk of the respiratory-distress syndrome by a rapid test for surfactant in amniotic fluid.

TL;DR: Analysis of 138 samples of amniotic fluid showed that an appreciable titer of the surfactant appears on the average at 33 weeks' estimated gestation but that the time of appearance is variable from 25 weeks to term.
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