Journal ArticleDOI
Amoxicillin plus clavulanic acid versus appendicectomy for treatment of acute uncomplicated appendicitis: an open-label, non-inferiority, randomised controlled trial
Vons C,Caroline Barry,Sophie Maitre,Karine Pautrat,Mahaut Leconte,Bruno Costaglioli,Mehdi Karoui,Arnaud Alves,Bertrand Dousset,Patrice Valleur,Bruno Falissard,Dominique Franco +11 more
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TLDR
Amoxicillin plus clavulanic acid was not non-inferior to emergency appendicectomy for treatment of acute appendicitis and Identification of predictive markers on CT scans might enable improved targeting of antibiotic treatment.About:
This article is published in The Lancet.The article was published on 2011-05-07. It has received 475 citations till now. The article focuses on the topics: Appendicitis & Amoxicillin.read more
Citations
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Journal ArticleDOI
Acute appendicitis: modern understanding of pathogenesis, diagnosis, and management
Aneel Bhangu,Kjetil Søreide,Kjetil Søreide,Salomone Di Saverio,Jeanette Hansson Assarsson,Frederick Thurston Drake +5 more
TL;DR: In this paper, a clinical classification is used to stratify management based on simple (non-perforated) and complex (gangrenous or perforated), although many patients remain with an equivocal diagnosis, which is one of the most challenging dilemmas.
Journal ArticleDOI
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial
Paulina Salminen,Hannu Paajanen,Tero Rautio,Pia Nordström,Markku Aarnio,Tuomo Rantanen,Risto Tuominen,Saija Hurme,Johanna Virtanen,Jukka-Pekka Mecklin,Juhani Sand,Airi Jartti,Irina Rinta-Kiikka,Juha Grönroos +13 more
TL;DR: Most patients randomized to antibiotic treatment for uncomplicated appendicitis did not require appendectomy during the 1-year follow-up period, and those who required appendectomy did not experience significant complications, despite the prespecified noninferiority margin.
Journal ArticleDOI
Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines
Salomone Di Saverio,Salomone Di Saverio,Mauro Podda,Belinda De Simone,Marco Ceresoli,Goran Augustin,Alice Gori,Marja A. Boermeester,Massimo Sartelli,Federico Coccolini,Antonio Tarasconi,Nicola De Angelis,Dieter G. Weber,Matti Tolonen,Arianna Birindelli,Walter L. Biffl,Ernest E. Moore,Michael D. Kelly,Kjetil Søreide,Jeffry L. Kashuk,Richard P. G. ten Broek,Carlos Augusto Gomes,Michael Sugrue,R. J. Davies,Dimitrios Damaskos,Ari Leppäniemi,Andrew W. Kirkpatrick,Andrew B. Peitzman,Gustavo Pereira Fraga,Ronald V. Maier,Raul Coimbra,Massimo Chiarugi,Gabriele Sganga,Adolfo Pisanu,Gian Luigi De' Angelis,Edward C.T.H. Tan,Harry van Goor,Francesco Pata,Isidoro Di Carlo,Osvaldo Chiara,Andrey Litvin,Fabio Cesare Campanile,Boris Sakakushev,G. Tomadze,Zaza Demetrashvili,Rifat Latifi,Fakri Abu-Zidan,Oreste Romeo,Helmut Segovia-Lohse,Gian Luca Baiocchi,David W da Costa,Sandro Rizoli,Zsolt J. Balogh,Cino Bendinelli,Thomas M. Scalea,Rao R. Ivatury,George C. Velmahos,Roland Andersson,Yoram Kluger,Luca Ansaloni,Fausto Catena +60 more
TL;DR: The 2020 WSES guidelines on AA aim to provide updated evidence-based statements and recommendations on each of the following topics: diagnosis, non-operative management for uncomplicated AA, timing of appendectomy and in-hospital delay, surgical treatment, and intra-operative grading of AA.
Journal ArticleDOI
The Global Incidence of Appendicitis: A Systematic Review of Population-based Studies.
Mollie Ferris,Samuel Quan,Belle S. Kaplan,Natalie A. Molodecky,Chad G. Ball,Greg W. Chernoff,Nij Bhala,Subrata Ghosh,Elijah Dixon,Siew C. Ng,Gilaad G. Kaplan +10 more
TL;DR: In the 21st century, the incidence of appendicitis or appendectomy is high in newly industrialized countries in Asia, the Middle East, and Southern America, and Northern America, while in most Western countries the incidence is stable.
Journal ArticleDOI
Safety and efficacy of antibiotics compared with appendicectomy for treatment of uncomplicated acute appendicitis: meta-analysis of randomised controlled trials
TL;DR: Antibiotics are both effective and safe as primary treatment for patients with uncomplicated acute appendicitis and initial antibiotic treatment merits consideration as a primary treatment option for early uncomplication appendiciti.
References
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Reporting of noninferiority and equivalence randomized trials: an extension of the CONSORT statement.
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Extended-spectrum β-lactamase-producing Enterobacteriaceae: an emerging public-health concern
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Statistics with Confidence : Confidence Intervals and Statistical Guidelines
TL;DR: This comprehensive collection of methods for using confidence intervals, illustrative worked examples and helpful checklists this is a truly practical guide for clinical readers to a fundamental aspect of medical statistics.
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Statistical guidelines for contributors to medical journals.
TL;DR: Comprehensive statistical guidelines are presented to give general information and advice about important aspects of statistical design, analysis, and presentation, and it is hoped that the guidelines present an uncontro versial view of the most frequently used and accepted statistical procedures.
Journal ArticleDOI
Randomized clinical trial of antibiotic therapy versus appendicectomy as primary treatment of acute appendicitis in unselected patients
TL;DR: This study aimed to evaluate antibiotic therapy in unselected men and women with acute appendicitis and found that antibiotic therapy could be an alternative to appendicectomy inappendicitis.