Journal ArticleDOI
An anion stimulated l-glutamic acid decarboxylase in non-neural tissues: Occurrence and subcellular localization in mouse kidney and developing chick embryo brain☆
TLDR
The evidence favors the hypothesis that at least two forms of GAD exist in animal tissues, and Pyruvate was the most effective organic anion tested in stimulating the kidney enzyme and was more effective than isomolar concentrations of Cl−.About:
This article is published in Biochemical Pharmacology.The article was published on 1970-03-01. It has received 111 citations till now. The article focuses on the topics: Aminooxyacetic acid & Glutamate decarboxylase.read more
Citations
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Journal ArticleDOI
The structural and functional heterogeneity of glutamic acid decarboxylase: a review.
Mark G. Erlander,Allan J. Tobin +1 more
TL;DR: Studies of the GABA-synthetic enzyme glutamate decarboxylase have demonstrated the structural and functional heterogeneity of brain GAD, and at least part of this heterogeneity derives from the existence of two GAD genes.
Book ChapterDOI
Transport and metabolism of glutamate and GABA in neurons are glial cells.
TL;DR: It is undoubtedly correct that these amino acids can be taken up into presynaptic nerve endings through high-affinity transport processes and it is even possible to distinguish between these transport mechanisms employing inhibitors that have been shown to be selective for the transport carriers.
Journal ArticleDOI
Localization of transmitter candidates in the brain: the hippocampal formation as a model
Journal ArticleDOI
Origin and distribution of glutamate decar☐ylase in substantia nigra of the cat
TL;DR: The results thus indicate that the fibers of the GAD-containing axon terminals in substantia nigra of the cat originate in putamen and nucleus caudatus, and the activity of GAD was always lower in the medial part of pars compacta, which contains the highest concentration of cell bodies.
Journal ArticleDOI
On the Role of Glial Cells in the Mammalian Nervous System UPTAKE, EXCRETION, AND METABOLISM OF PUTATIVE NEUROTRANSMITTERS BY CULTURED GLIAL TUMOR CELLS
TL;DR: The data are consistent with a possible role of central nervous system glial cells in the modulation of neuronal excitability via control of the levels of neuroactive substances in the extracellular milieu of neurons.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
A series of normal stages in the development of the chick embryo
TL;DR: The preparation of a series of normal stages of the chick embryo does not need justification at a time when chick ernbryos are not only widely used in descriptive and experimental embryology but are proving to be increasingly valuable in medical research, as in work on viruses and cancer.
Book
Chromatographic and electrophoretic techniques
TL;DR: The reviewer was left with the impression that more attention is paid to these tests in the author's departments than is usually done in Great Britain.
Journal ArticleDOI
Subcellular distribution of the enzymes of the glutamic acid, glutamine and gamma-aminobutyric acid cycles in rat brain.
L. Salganicoff,E. M. De Robertis +1 more
TL;DR: The function of this group of amino acids seems to be related to the complex structure of the CNS and the existence of numerous compartments and metabolic pools.
Related Papers (5)
Subcellular distribution of the enzymes of the glutamic acid, glutamine and gamma-aminobutyric acid cycles in rat brain.
L. Salganicoff,E. M. De Robertis +1 more