Journal ArticleDOI
Analysis of pulsatile, viscous blood flow through diseased coronary arteries of man*?
TLDR
The rheologic effects of multiple “non-obstructive” plaques in main coronary arteries of man were examined by numerically solving the fluid dynamic equations of motion for pulsatile viscous flow of blood through an arterial section using the actual variation of flow rate during the cardiac cycle.About:
This article is published in Journal of Biomechanics.The article was published on 1977-01-01. It has received 122 citations till now. The article focuses on the topics: Pulsatile flow & Shear stress.read more
Citations
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Journal ArticleDOI
Biochemistry and Genetics of von Willebrand Factor
TL;DR: Growing body of information about VWF synthesis, structure, and function has allowed the reclassification of VWD based upon distinct pathophysiologic mechanisms that appear to correlate with clinical symptoms and the response to therapy.
Journal ArticleDOI
Initiation of Platelet Adhesion by Arrest onto Fibrinogen or Translocation on von Willebrand Factor
TL;DR: Two distinct mechanisms initiating the adhesion of flowing platelets to thrombogenic surfaces are identified: glycoprotein Ib alpha binding to immobilized von Willebrand factor (vWF) and activated alpha IIb beta 3.
Journal ArticleDOI
Specific Synergy of Multiple Substrate–Receptor Interactions in Platelet Thrombus Formation under Flow
TL;DR: Hemodynamic forces and substrate characteristics define the platelet adhesion pathways leading to thrombogenesis.
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Involvement of large plasma von Willebrand factor (vWF) multimers and unusually large vWF forms derived from endothelial cells in shear stress-induced platelet aggregation.
TL;DR: In this article, a fluid shear stress of 180 dyn/cm2 was applied for 0.5 and 5 min to platelets in citrated plasma or blood in a cone and plate viscometer with minimal platelet surface interactions.
Journal ArticleDOI
The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stress.
Yasuo Ikeda,Makoto Handa,Koichi Kawano,Tetsuji Kamata,Mitsuru Murata,Y. Araki,Hironobu Anbo,Y. Kawai,K Watanabe,Ichiro Itagaki +9 more
TL;DR: Von Willebrand factor in the absence of exogenous agonists can mediate platelet aggregation in experimental conditions that may mimic the hemorheological situation of partially occluded arteries and may play a relevant role in thrombogenesis.
References
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Journal ArticleDOI
The Numerical Solution of Parabolic and Elliptic Differential Equations
D. W. Peaceman,H. H. Rachford +1 more
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A practical method for numerical evaluation of solutions of partial differential equations of the heat-conduction type
TL;DR: In this paper, the authors present methods of evaluating numerical solutions of the non-linear partial differential equation to the boundary conditions A, k, q are known constants, where q is the rate of heat generation.
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Physiologic basis for assessing critical coronary stenosis : Instantaneous flow response and regional distribution during coronary hyperemia as measures of coronary flow reserve
TL;DR: Flow response and regional distribution during coronary hyperemia caused by Hypaque are quantitative measures for physiologically assessing critical coronary stenosis and flow reserve with potential applicability to patients.
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Acute Vascular Endothelial Changes Associated with Increased Blood Velocity Gradients
TL;DR: The purpose of this study is to quantify the acute changes in endothelial histology that are associated with an induced increase in blood velocity and to establish the “normal” endothelial cell population density as a function of stress exposure.
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Flow characteristics in models of arterial stenoses. II. Unsteady flow.
Donald F. Young,Frank Y. Tsai +1 more
TL;DR: It is shown that three dimensionless parameters can be used to characterize the unsteady flow in a stenosis and the effect of unsteadiness is investigated experimentally using axisymmetric and nonsymmetric models.