Journal ArticleDOI
Anaphylaxis during anesthesia in France: An 8-year national survey
TLDR
The incidence of allergic reactions during anesthesia, estimated on a national basis, is higher than previously estimated and the similar incidence of reactions according to sex before adolescence suggests a role for sex hormones in the increase of anaphylaxis observed in women.Abstract:
Background More attention should be paid to rare serious adverse events such as anaphylaxis to increase the safety of anesthesia. Objective To report the results of an 8-year survey of anaphylaxis during anesthesia in France. Methods Data from patients who experienced anaphylaxis between January 1, 1997, and December 31, 2004, were analyzed. Estimated incidences were obtained by combining this database with data from the French pharmacovigilance system by using a capture-recapture method. The number of patients exposed to the offending agents was obtained from data collected during the national survey of anesthesia practice. Results A total of 2516 patients was included. A diagnosis of IgE-mediated reaction was established in 1816 cases (72.18%). The most common causes were neuromuscular blocking agents ([NMBAs]; n = 1067; 58.08%), latex (n = 361; 19.65%), and antibiotics (n = 236; 12.85%). The median annual incidence per million procedures was higher for females 154.9 (5th-95th percentile, 117.2-193.1) than for males 55.4 (5th-95th percentile, 42.0-68.0). It reached 250.9 (5th-95th percentile, 189.8-312.9) for women in cases of allergic reactions to NMBAs. In children, a diagnosis of IgE-mediated reactions was obtained in 122 cases (45.9%). The most common causes were latex (n = 51; 41.8%), NMBAs (n = 39; 31.97%), and antibiotics (n = 11; 9.02%). In contrast with adults, no female predominance was observed. Conclusion The incidence of allergic reactions during anesthesia, estimated on a national basis, is higher than previously estimated. These results should be taken into account in the evaluation of the benefit-to-risk ratio of the various anesthetic techniques in individuals. The similar incidence of reactions according to sex before adolescence suggests a role for sex hormones in the increase of anaphylaxis observed in women.read more
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Serum sickness-like reactions in Iranian children: a registry-based study in a referral center.
Azam Mohsenzadeh,Masoud Movahedi,Mohammad Saatchi,Nima Parvaneh,Mansoureh Shariat,Asghar Aghamohammadi,Mohammad Gharagozlou +6 more
TL;DR: This study showed that among the antibiotics, Co-amoxiclav and Cefixime are more prevalent and a review of prescribing these two antibiotics for the treatment of the children's infections is essential if this finding is confirmed by other Iranian scholars.
Journal ArticleDOI
Management of perioperative anaphylaxis: Systematic review
Biruk Adie Admass,Alemayehu Eshetu Hassen,Abatneh Feleke Agegnehu,Mamaru Mollalign Temesgen,Natnael Atnafu Gebeyehu,Yonas Admasu Ferede,Biresaw Ayen Tegegne +6 more
TL;DR: In this article , a systematic review of the literature on perioperative anaphylaxis is presented, in order to establish a clear plan for handling periophylaxis.
Journal ArticleDOI
Allergic and other adverse reactions to drugs used in anesthesia and surgery
TL;DR: The list of drugs patients may be exposed to during the perioperative and post-operative periods is potentially extensive as mentioned in this paper , including induction agents, neuromuscular blocking drugs (NMBDs), opioids, antibiotics, sugammadex, colloids, local anesthetics, polypeptides, antifibrinolytic agents, heparin and related anticoagulants, blue dyes, chlorhexidine, and a range of other agents depending on several factors related to individual patients' clinical condition and progress in the postoperative recovery period.
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