Journal ArticleDOI
Androgen and estrogen receptors immunolocalization in the sand rat (Psammomys Obesus) cauda epididymis
Rafik Menad,Rafik Menad,Meriem Fernini,Lynda Lakabi,Souaâd Smaï,Thérèse Gernigon-Spychalowicz,Khammar Farida,Xavier Bonnet,Elara Moudilou,Jean-Marie Exbrayat +9 more
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In this article, the authors used immunochemistry to localize androgen and estrogen receptors in the cauda in the fat sand rat (Psammomys obesus) and compared results obtained during the breeding versus resting seasons.About:
This article is published in Acta Histochemica.The article was published on 2021-02-01. It has received 4 citations till now. The article focuses on the topics: Efferent ducts & Apical cytoplasm.read more
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Crucial Convolution: Genetic and Molecular Mechanisms of Coiling during Epididymis Formation and Development in Embryogenesis
Joanne Wong,Jemma G. Gasperoni,Jarrad N Fuller,Sylvia V.H. Grommen,Bert De Groef,Cathryn A. Hogarth,Sebastian Dworkin +6 more
TL;DR: This review of known genetic and molecular factors that operate to pattern complex, coiled structures, with a primary focus on the epididymis as an excellent model organ to examine coiling, discusses genetic mechanisms involving coiling in the seminiferous tubules and intestine to establish the final form and function in the mature organism.
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Effects of testosterone on skin structure and factors related to androgen conversion and binding in Hetian sheep
TL;DR: This study suggests that androgens can be effective in regulating sebum production in sheep and will help advance research efforts to further explore the molecular and cellular mechanisms by which androgens modify sheep follicles and sebaceous glands.
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Progress in research on the reproductive function in the sand rat (Psammomys obesus): A review.
TL;DR: In this article , the authors review and sum up the progress in the understanding of the reproductive anatomo-histo-physiology of Psammomys obesus, in order to facilitate future research in this area and expose further perspectives for researchers.
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The appendage of the testis: morphogenesis, structural and functional characteristics in physiological and pathological conditions
N. N. Shevlyuk,M. F. Ryskulov +1 more
TL;DR: Morphological equivalents of the negative influence of various damaging factors are basically similar, which evidences the presence of a nonspecific mechanism of reaction to the action of adverse factors formed during evolution.
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Generation and reproductive phenotypes of mice lacking estrogen receptor β
John H. Krege,Jeffrey B. Hodgin,John F. Couse,Eva Enmark,Margaret Warner,Joel F. Mahler,Madhabananda Sar,Kenneth S. Korach,Jan-Åke Gustafsson,Oliver Smithies +9 more
TL;DR: The generation of mice lacking estrogen receptor beta (ERbeta -/-) is described by insertion of a neomycin resistance gene into exon 3 of the coding gene by using homologous recombination in embryonic stem cells to determine the role of ERbeta in bone and cardiovascular homeostasis.
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Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes.
TL;DR: Results reveal a functional redundancy between ERalpha and ERbeta for ovarian folliculogenesis, and strongly suggest that ERbeta plays an important role in mediating the stimulatory effects of estrogens on granulosa cell proliferation.
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Tissue Distribution and Quantitative Analysis of Estrogen Receptor-α (ERα) and Estrogen Receptor-β (ERβ) Messenger Ribonucleic Acid in the Wild-Type and ERα-Knockout Mouse
TL;DR: The optimization and use of an RNase protection assay able to detect and distinguish messenger RNA (mRNA) transcripts from both the ERalpha and ERbeta genes in the mouse suggest that the biological functions of the ERbeta protein may be dependent on the presence of ERalpha in certain cell types and tissues.
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Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility
Edward M. Eddy,Todd F. Washburn,Donna O. Bunch,Eugenia H. Goulding,Beth C. Gladen,Dennis B. Lubahn,Kenneth S. Korach +6 more
TL;DR: It is suggested that estrogen action is required for fertility in male mice and that the mutation of the ER in ERKO males leads to reduced mating frequency, low sperm numbers, and defective sperm function.
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New insights into epididymal biology and function
TL;DR: The data indicate that the human epididymis plays an important role in sperm maturation but has unique properties compared with animal models, and new insights that ultimately could improve human health are provided.