Journal ArticleDOI
Angiotensin receptor blockers and the kidney: possible advantages over ACE inhibition?
Reads0
Chats0
TLDR
AT1 receptor blockade may offer additional clinical benefits over ACE inhibitor treatment, particularly in the kidney, where AT1-receptor blockade does not cause the fall in glomerular filtration rate seen withACE inhibitor treatment.Abstract:
This review deals with similarities and differences between the effects of ACE inhibitors and AT1-receptor blockers in the kidney. Specific receptor blockade has demonstrated that the beneficial effects of AT1 blockers arise from two mechanisms: the reduction of the AT1 receptor mediated response and the increase in plasma levels of Ang II through the AT1-receptor blockade, which leads to increased stimulation of the AT2 receptor (the so-called yin-yang effect). Both ACE inhibition and AT1-receptor blockade provide significant renal protection in the majority of experimental animal models of kidney diseases. AT1 receptor blockade may offer additional clinical benefits over ACE inhibitor treatment, particularly in the kidney, where AT1-receptor blockade does not cause the fall in glomerular filtration rate seen with ACE inhibitor treatment. A number of long-term clinical studies currently running should show the real value of this new class of compounds in the management of hypertension and associated cardiorenal diseases.read more
Citations
More filters
Journal ArticleDOI
Angiotensin II AT1 receptor blockade decreases vasopressin-induced water reabsorption and AQP2 levels in NaCl-restricted rats.
TL;DR: Ang II AT(1) receptor blockade in DDAVP-treated rats was associated with decreased urine concentration and decreased AQP2 and AQP1 expression, suggesting that ANG II AT-1 receptor activation plays a significant role in regulating aquaporin and sodium transporter expression and modulating urine concentration in vivo.
Journal ArticleDOI
Increased angiotensin II type-2 receptor density in hyperplasia, DCIS and invasive carcinoma of the breast is paralleled with increased iNOS expression
TL;DR: It is shown that AT2 receptor and iNOS overexpression are associated with breast disease, further confirming the involvement of the components of the renin-angiotensin system in the aetiology of breast cancer.
Journal ArticleDOI
Current approaches to the management of smoking cessation
TL;DR: Ce dernier est surtout exprime lors du developpement - ou son role exact est mal connu - et, chez l'adulte, dans des tissus comme l'uterus, l'ovaire, le rein, the rein, les vaisseaux and le coeur, essentiellement lors of l'insuffisance cardiaque and de l'ischemie myocardique.
Journal ArticleDOI
Angiotensin II AT1 and AT2 Receptors Contribute to Maintain Basal Adrenomedullary Norepinephrine Synthesis and Tyrosine Hydroxylase Transcription
Miroslava Jezova,Ines Armando,Claudia Bregonzio,Zu Xi Yu,Sujuan Qian,Victor J. Ferrans,Hans Imboden,Juan M. Saavedra +7 more
TL;DR: The hypothesis of an AT(1)/AT(2) receptor cross-talk in the adrenomedullary ganglion cells is supported, and a role for both receptor types on the selective regulation of basal NE, but not epinephrine formation, and in theregulation of basal TH transcription is suggested.
Journal ArticleDOI
Transient prehypertensive treatment in spontaneously hypertensive rats: a comparison of spironolactone and losartan regarding long-term blood pressure and target organ damage.
Marcus Baumann,J. J. Rob Hermans,Ben J. A. Janssen,Carine J. Peutz-Kootstra,Oliver Witzke,Uwe Heemann,Jos F.M. Smits,Harry A.J. Struijker Boudier +7 more
TL;DR: Although transient spironolactone treatment leads to prolonged blood pressure reduction and reduced collagen deposition, long-term organ protection only partially exists, and transient sp ironolact one treatment is less effective than transient losartan treatment.
References
More filters
Book
Textbook of Medical Physiology
Arthur C. Guyton,John E. Hall +1 more
TL;DR: Textbook of medical physiology , Textbook ofmedical physiology , کتابخانه دیجیتال جندی شاپور اهواز
Journal ArticleDOI
Textbook of Medical Physiology
TL;DR: Textbook of medical physiology, Textbook of Medical Physiology, this paper, textbook of medicine, textbooks of medical science, text book of medical literature, textbook medical physiology.
Journal ArticleDOI
The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The collaborative study group
TL;DR: Captopril protects against deterioration in renal function in insulin-dependent diabetic nephropathy and is significantly more effective than blood-pressure control alone.
Journal ArticleDOI
The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy.
TL;DR: Whether captopril has kidney-protecting properties independent of its effect on blood pressure in diabetic nephropathy is determined.
Journal Article
International Union of Pharmacology. XXIII. The Angiotensin II Receptors
TL;DR: Although AT(1) receptors mediate most of the known actions of Ang II, the AT(2) receptor contributes to the regulation of blood pressure and renal function and the development of specific nonpeptide receptor antagonists has led to major advances in the physiology, pharmacology, and therapy of the renin-angiotensin system.
Related Papers (5)
Does blockade of angiotensin II receptors offer clinical benefits over inhibition of angiotensin-converting enzyme?
Marc de Gasparo,Nigel Levens +1 more