Journal ArticleDOI
Antidepressant drugs increase the locomotor hyperactivity induced by MK-801 in rats.
TLDR
Results indicate that the dopamine system may be involved, at least in part, in the potentiating effect of the combined treatment with AD + MK-801, and this effect was completely blocked by haloperidol and only partly by prazosin.Abstract:
MK-801, a non-competitive NMDA receptor antagonist, induced the locomotor hyperactivity in rats. Imipramine (IMI), amitriptyline (AMI), citalopram (CIT) given acutely increased the MK-801-induced locomotor hyperactivity. Mianserin (MIA) showed a similar but weaker effect. Haloperidol completely blocked the hyperactivity induced by the antidepressant drug (AD) + MK-801. Prazosin had an only weak antagonistic effect. Repeated treatment with AD increased the MK-801 locomotor hyperactivity to a greater extent than acute treatment. This effect was completely blocked by haloperidol and only partly by prazosin. The obtained results indicate that the dopamine system may be involved, at least in part, in the potentiating effect of the combined treatment with AD + MK-801.read more
Citations
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Glutamate and Depression
Ian A. Paul,Phil Skolnick +1 more
TL;DR: Recent data indicate that a single intravenous dose of an NMDA receptor antagonist is sufficient to produce sustained relief from depressive symptoms, and represent exciting and novel avenues to both understand depressive symptomatology and develop more effective antidepressants.
Journal ArticleDOI
Altered dendritic spine density in animal models of depression and in response to antidepressant treatment.
TL;DR: The results suggest that long‐lasting alterations in hippocampal dendritic spine density contribute to the neural mechanism underlying the olfactory bulbectomy model of depression, but not the neonatal clomipramine or maternal deprivation models.
Journal ArticleDOI
Effects of MK-801 and antidepressant drugs in the forced swimming test in rats.
TL;DR: The results indicate that synergism may exist between antidepressants and MK-801 and that the reduction of the immobility time was also observed in those experimental paradigms in which the locomotor activity was not increased.
Journal ArticleDOI
The Role of Sigma Receptors in Depression
Jordanna E. Bermack,Guy Debonnel +1 more
TL;DR: Sigma ligands have potential as antidepressant medications with a fast onset of action as they produce a rapid modulation of the serotonergic system in the DRN and the glutamatergic transmission in the hippocampus and may provide an alternative to the antidepressants currently available and may prove to be beneficial for treatment-resistant depressed patients.
Journal ArticleDOI
The N-methyl-D-aspartate receptor, synaptic plasticity, and depressive disorder. A critical review.
TL;DR: The role of the NMDA receptor and its role in synaptic plasticity in depression was reviewed in this article, where the authors found that chronic administration of antidepressant agents perturb NMDA-dependent synaptic plasticities in the hippocampus.
References
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Journal ArticleDOI
The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.
Erik H. F. Wong,John A. Kemp,Tony Priestley,Antony R. Knight,Geoffrey Neil Woodruff,L. L. Iversen +5 more
TL;DR: Neurophysiological studies in vitro, using a rat cortical-slice preparation, demonstrated a potent, selective, and noncompetitive antagonistic action of MK-801 on depolarizing responses to N-Me-D-Asp but not to kainate or quisqualate, providing an explanation for the mechanism of action ofMK-801 as an anticonvulsant.
Journal ArticleDOI
Functional antagonists at the NMDA receptor complex exhibit antidepressant actions
Ramon Trullas,Phil Skolnick +1 more
TL;DR: The hypothesis that pathways subserved by the NMDA subtype of glutamate receptors are involved in the pathophysiology of affective disorders may have heuristic value and that substances capable of reducing neurotransmission at theNMDA receptor complex may represent a new class of antidepressants is investigated.
Journal ArticleDOI
Possible therapeutic applications of antagonists of excitatory amino acid neurotransmitters
TL;DR: There are theoretical and experimental grounds for studying therapeutic applications in cerebral ischaemia and in chronic degenerative disorders of the motor system and in neurology and psychiatry.
Journal ArticleDOI
Central sympathomimetic activity of (+)-5-methyl-10, 11-dihydro-5H-dibenzo [a, d] cyclohepten-5, 10-imine(MK-801), a substance with potent anticonvulsant, central sympathomimetic and apparent anxiolytic properties
TL;DR: Besides being a potent anticonvulsant, MK‐801 demonstrated selectivity, since much higher doses were required in mice to block clonic convulsions produced by pentylenetetrazol and tonic seizures caused by strychnine than were needed against electroshock or bicuculline.
Journal ArticleDOI
[3H]MK‐801 Labels a Site on the N‐Methyl‐D‐Aspartate Receptor Channel Complex in Rat Brain Membranes
TL;DR: The data suggest that [3H]MK‐801 labels a high‐affinity site on the NMDA receptor channel complex, distinct from theNMDA recognition site, which is responsible for the blocking action of MK‐801 and other noncompetitive NMda receptor antagonists.
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