Journal ArticleDOI
Antidepressants for the new millennium.
TLDR
It is hypothesized that two different treatment strategies converge to produce an identical functional endpoint: a region-specific dampening of NMDA receptor function, providing a rudimentary framework for discovering novel antidepressants.About:
This article is published in European Journal of Pharmacology.The article was published on 1999-06-30. It has received 367 citations till now. The article focuses on the topics: Antidepressant & Serotonin.read more
Citations
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Journal ArticleDOI
A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression
Carlos A. Zarate,Jaskaran Singh,Paul J. Carlson,Nancy E. Brutsche,Rezvan Ameli,David A. Luckenbaugh,Dennis S. Charney,Husseini K. Manji +7 more
TL;DR: Robust and rapid antidepressant effects resulted from a single intravenous dose of an N-methyl-D-aspartate antagonist; onset occurred within 2 hours postinfusion and continued to remain significant for 1 week.
Journal ArticleDOI
Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disorders.
TL;DR: A paradigm shift from a monoamine hypothesis of depression to a neuroplasticity hypothesis focused on glutamate may represent a substantial advancement in the working hypothesis that drives research for new drugs and therapies.
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Activation of the TrkB Neurotrophin Receptor Is Induced by Antidepressant Drugs and Is Required for Antidepressant-Induced Behavioral Effects
Tommi Saarelainen,Panu Hendolin,Guilherme de Araújo Lucas,Eija Koponen,Mikko Sairanen,Ewen MacDonald,Karin Agerman,Annakaisa Haapasalo,Hiroyuki Nawa,Raquel Aloyz,Patrik Ernfors,Eero Castrén +11 more
TL;DR: The data suggest that antidepressants acutely increase trkB signaling in a BDNF-dependent manner in cerebral cortex and that this signaling is required for the behavioral effects typical of antidepressant drugs.
Journal ArticleDOI
Enhancing neuronal plasticity and cellular resilience to develop novel, improved therapeutics for difficult-to-treat depression.
Husseini K. Manji,Jorge A. Quiroz,Jonathan R. Sporn,Jennifer L. Payne,Kirk D. Denicoff,Neil A. Gray,Carlos A. Zarate,Dennis S. Charney +7 more
TL;DR: Preclinical studies have shown that critical molecules in neurotrophic signaling cascades are long-term targets for antidepressant agents and antidepressant potentiating modalities, suggesting that effective treatments provide both trophic and neurochemical support, which serves to enhance and maintain normal synaptic connectivity.
Journal ArticleDOI
Glutamate and Depression
Ian A. Paul,Phil Skolnick +1 more
TL;DR: Recent data indicate that a single intravenous dose of an NMDA receptor antagonist is sufficient to produce sustained relief from depressive symptoms, and represent exciting and novel avenues to both understand depressive symptomatology and develop more effective antidepressants.
References
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Journal ArticleDOI
Differential Display of Eukaryotic Messenger RNA by Means of the Polymerase Chain Reaction
Peng Liang,Arthur B. Pardee +1 more
TL;DR: A method to separate and clone individual messenger RNAs (mRNAs) by means of the polymerase chain reaction using a set of oligonucleotide primers, one being anchored to the polyadenylate tail of a subset of mRNAs, the other being short and arbitrary in sequence so that it anneals at different positions relative to the first primer.
Journal ArticleDOI
Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans: Psychotomimetic, perceptual, cognitive, and neuroendocrine responses.
John H. Krystal,Laurence P. Karper,John Seibyl,Glenna K. Freeman,Richard C. Delaney,J. Douglas Bremner,George R. Heninger,Malcolm B. Bowers,Dennis S. Charney +8 more
TL;DR: These data indicate that N-methyl-D-aspartate antagonists produce a broad range of symptoms, behaviors, and cognitive deficits that resemble aspects of endogenous psychoses, particularly schizophrenia and dissociative states.
Journal ArticleDOI
Recent advances in the phencyclidine model of schizophrenia.
TL;DR: It was found that PCP-induced psychotomimetic effects are associated with submicromolar serum concentrations of PCP and the findings suggest that endogenous dysfunction of NMDA receptor-mediated neurotransmission might contribute to the pathogenesis of schizophrenia.
Journal ArticleDOI
Regulation of BDNF and trkB mRNA in Rat Brain by Chronic Electroconvulsive Seizure and Antidepressant Drug Treatments
TL;DR: The enhanced induction and prolonged expression of BDNF in response to chronic ECS and antidepressant drug treatments could promote neuronal survival, and protect neurons from the damaging effects of stress.
Related Papers (5)
Functional antagonists at the NMDA receptor complex exhibit antidepressant actions
Ramon Trullas,Phil Skolnick +1 more