Open AccessJournal Article
Antidiabetic activity of heart wood of Pterocarpus marsupium Roxb. and analysis of phytoconstituents.
Akansha Mishra,Rohit Srivastava,Swayam Prakash Srivastava,Sudeep Gautam,Akhilesh K. Tamrakar,Rakesh Maurya,Arvind K. Srivastava +6 more
TLDR
It may primarily be concluded that phenolic-C-glycosides present in P. marsupium heart wood are the phytoconstituents responsible for the antihyperglycemic activity and validate the claim of antidiabetic activity of heart wood of P. Marsupium.Abstract:
The crude powder, ethanolic extract and aqueous, chloroform, hexane and n-butanol soluble fractions of ethanolic extract of heart wood of P. marsupium showed marked improvement on oral glucose tolerance post sucrose load in normal rats. All these fractions except aqueous fraction showed improvement on oral glucose tolerance post sucrose load on streptozotocin (STZ)-induced diabetic rats. The crude powder, ethanolic extract and hexane and n-butanol fractions showed marked decline in blood glucose level on STZ-induced diabetic rats. The ethanolic extract (100 mg/kg body weight) when given to STZ-induced diabetic rats for 10 consecutive days declined blood glucose, improved OGTT and increased their serum insulin levels. The ethanolic extract also showed marked improvement on oral glucose tolerance on high fat-low dosed STZ-induced diabetic rats and neonatally STZ treated rats. The ethanolic extract of P. marsupium also showed marked antidyslipidemic effects on high fat diet fed Syrian golden hamsters. Altered renal and hepatic function markers and serum insulin levels of high fat diet fed-low dosed STZ-treated diabetic rats were also found towards normalization when these animals were treated with ethanolic extract of P. marsupium for 28 consecutive days. The four out of five phenolic C-glycosides isolated from n-butanol fraction of ethanolic extract of P. marsupium enhanced glucose uptake by skeletal muscle cells (C2C12) in a dose dependent manner. It may primarily be concluded that phenolic-C-glycosides present in P. marsupium heart wood are the phytoconstituents responsible for the antihyperglycemic activity and validate the claim of antidiabetic activity of heart wood of P. marsupium.read more
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Role of medicinal plants in the management of diabetes mellitus: a review
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Natural Tannin Wood Extracts as a Potential Food Ingredient in the Food Industry.
Silvia Molino,Natalia A. Casanova,José Angel Rufián Henares,Mariano Enrique Fernandez Miyakawa +3 more
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Ethnobotany of India.
TL;DR: In this article, the authors present a survey of reviews on the Ethnobotany of India, focusing on three categories: Vegetation and Flora, Vegetation, and Ethnic Diversity.
References
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Journal ArticleDOI
Fructose, weight gain, and the insulin resistance syndrome
TL;DR: Although there are existing data on the metabolic and endocrine effects of dietary fructose that suggest that increased consumption of fructose may be detrimental in terms of body weight and adiposity and the metabolic indexes associated with the insulin resistance syndrome, much more research is needed to fully understand the metabolic effect of dietaryructose in humans.
Journal ArticleDOI
New drug targets for type 2 diabetes and the metabolic syndrome
TL;DR: Emerging knowledge of key pathogenic mechanisms, such as the impairment of glucose-stimulated insulin secretion and the role of 'lipotoxicity' as a probable cause of hepatic and muscle resistance to insulin's effects on glucose metabolism, has led to a host of new molecular drug targets.
Journal ArticleDOI
Comparative evaluation of hypoglycaemic activity of some Indian medicinal plants in alloxan diabetic rats
TL;DR: Present studies besides confirming hypoglycaemic activities of the experimental herbal samples, help identify more potent indigenous hyp glucosecaemic herbs (in crude ethanolic extract) from the comparative study of the reported experimental results.
Journal ArticleDOI
Relation of diabetic control to development of microvascular complications.
TL;DR: The opinion of the author is that strict control of diabetes is worthwile in patients with long life expectancy and no psychological, social or cultural handicaps.
Journal ArticleDOI
Antihyperlipidemic effect of Eugenia jambolana seed kernel on streptozotocin-induced diabetes in rats.
TL;DR: EJs- kernel possesses hypolipidemic effect, which may be due to the presence of flavonoids, saponins, glycosides and triterpenoids in the extract, which is anticipated to have biological significance and provide a scientific rationale for the use of EJs-kernel as an anti-diabetic plant.
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