Journal ArticleDOI
Antihepatotoxic actions of gingerols and diarylheptanoids
Hiking Hiroshi,Kiso Yoshinobu,Kato Nobuharu,Hamada Yasumasa,Shioiri Takayuki,Aiyama Ritsuo,Itokawa Hideji,Kiuchi Fumiyuki,Sankawa Ushio +8 more
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TLDR
The carbon tetrachloride assay appeared to be most useful in defining structure-activity relationships and the antihepatotoxic activity of gingerols and shogaols was dependent on the length of the side chain with the [7]- and [8]-companions eliciting the strongest activity.About:
This article is published in Journal of Ethnopharmacology.The article was published on 1985-09-01. It has received 64 citations till now. The article focuses on the topics: Diarylheptanoids.read more
Citations
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Gingerols and shogaols: Important nutraceutical principles from ginger
Ruchi Badoni Semwal,Deepak Kumar Semwal,Sandra Combrinck,Alvaro M. Viljoen,Alvaro M. Viljoen +4 more
TL;DR: Significant evidence is highlighted indicating that these phenolic compounds could serve as important lead molecules for the development of therapeutic agents to treat various life-threatening human diseases, particularly cancer.
Journal ArticleDOI
Chemoprotective properties of some pungent ingredients present in red pepper and ginger
TL;DR: Recent studies reveal substantial antigenotoxic and anticarcinogenic effects of capsaicin, suggesting this compound as another important dietary phytochemical with a potential chemopreventive activity.
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LC–MS/MS analysis, antioxidant and anticholinergic properties of galanga (Alpinia officinarum Hance) rhizomes
Leyla Polat Kose,İlhami Gülçin,İlhami Gülçin,Ahmet C. Gören,Jacek Namiesnik,Alma Leticia Martinez-Ayala,Shela Gorinstein +6 more
TL;DR: In this paper, the authors investigated the antioxidant and anticholinergic properties of Galanga (Alpinia officinarum Hance) rhizome, which is a member of the ginger family (Zingiberaceae).
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The stability of gingerol and shogaol in aqueous solutions.
TL;DR: It was found that gingerol exhibited novel reversible kinetics, in which it undergoes dehydration-hydration transformations with shogaol, the major degradation product, and degradation rates were found to be pH dependent with greatest stability observed at pH 4.
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Bioassay-guided isolation and identification of antifungal compounds from ginger
C. Ficker,Myron L. Smith,Koffi Akpagana,Messanvi Gbeassor,J. Zhang,Tony Durst,R. Assabgui,J. T. Arnason +7 more
TL;DR: Ginger extracts standardized on the basis of the identified compounds, could be considered as antifungal agents for practical therapy.
References
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Pharmacological studies on ginger. i. pharmacological actions of pungent constituents, (6)-gingerol and (6)-shogaol
TL;DR: General pharmacological studies were performed on ( 6)-gingerol and (6)-shogaol which are the pungent constituents of ginger which produced an inhibition of spontaneous motor activity, an antipyretic and analgesic effects, prolonged hexobarbital-induced sleeping time, and an intense antitussive effect in comparison with dihydrocodeine phosphate.
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Antihepatotoxic principles of Curcuma longa rhizomes.
TL;DR: An extract of the crude drug “ukon”, the rhizomes of CURCUMA LONGA, exhibited intense preventive activity against carbon tetrachloride-induced liver injury in primary cultured rat hepatocytes and curcuminoids were shown to possess significant antihepatotoxic action.
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Inhibitors of prostaglandin biosynthesis from ginger.
TL;DR: In addition to [6]-gingerol four new constituents were isolated as potent inhibitors of prostaglandin (PG) biosynthesis from ginger, the roots of Zingiber officinale Roscoe.
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Assay method for antihepatotoxic activity using carbon tetrachloride induced cytotoxicity in primary cultured hepatocytes.
TL;DR: An IN VITRO assay method for antihepatotoxic activity using carbon tetrachloride-induced lesion in primary cultured mouse and rat liver cells was established and good correlation of results obtained with those by IN VIVO assay methods was corroborated by screening of some natural products.
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Inhibitors of prostaglandin biosynthesis from alpinia officinarum
TL;DR: In this paper, three diarylheptanoids were isolated as inhibitors of prostaglandin biosynthesis from the methanol extract of Alpinia offioinarum Hance.