Journal ArticleDOI
Gingerols and shogaols: Important nutraceutical principles from ginger
Ruchi Badoni Semwal,Deepak Kumar Semwal,Sandra Combrinck,Alvaro M. Viljoen,Alvaro M. Viljoen +4 more
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TLDR
Significant evidence is highlighted indicating that these phenolic compounds could serve as important lead molecules for the development of therapeutic agents to treat various life-threatening human diseases, particularly cancer.About:
This article is published in Phytochemistry.The article was published on 2015-09-01. It has received 379 citations till now. The article focuses on the topics: Gingerol.read more
Citations
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Plants of the Genus Zingiber as a Source of Bioactive Phytochemicals: From Tradition to Pharmacy
Mehdi Sharifi-Rad,Elena Maria Varoni,Bahare Salehi,Javad Sharifi-Rad,Javad Sharifi-Rad,Karl R. Matthews,Seyed Abdulmajid Ayatollahi,Seyed Abdulmajid Ayatollahi,Farzad Kobarfard,Salam A. Ibrahim,Dima Mnayer,Zainul Amiruddin Zakaria,Zainul Amiruddin Zakaria,Majid Sharifi-Rad,Zubaida Yousaf,Marcello Iriti,Adriana Basile,Daniela Rigano +17 more
TL;DR: A literature overview on Zingiber spp.
Journal ArticleDOI
Protective and therapeutic potential of ginger (Zingiber officinale) extract and [6]-gingerol in cancer: A comprehensive review.
Rosália Maria Tôrres de Lima,Antonielly Campinho dos Reis,Ag-Anne Pereira Melo de Menezes,José Victor de Oliveira Santos,José Williams Gomes de Oliveira Filho,Jose Ferreira,Marcus Vinícius Oliveira Barros de Alencar,Ana Maria Oliveira Ferreira da Mata,Ishaq N. Khan,Amirul Islam,Shaikh Jamal Uddin,Eunus S. Ali,Muhammad Torequl Islam,Swati Tripathi,Siddhartha Kumar Mishra,Mohammad S. Mubarak,Ana Amélia de Carvalho Melo-Cavalcante +16 more
TL;DR: Data collected from experimental (in vitro or in vivo) and clinical studies discussed in this review indicate that ginger derivatives, in the form of an extract or isolated compounds, exhibit relevant antiproliferative, antitumor, invasive, and anti‐inflammatory activities.
Journal ArticleDOI
Clinical aspects and health benefits of ginger (Zingiber officinale) in both traditional Chinese medicine and modern industry
TL;DR: The obtained findings suggest potential of ginger extract as an additive in the food and pharmaceutical industries.
Journal ArticleDOI
Pharmacotherapeutic potential of ginger and its compounds in age-related neurological disorders.
TL;DR: It is concluded that the active ingredients in ginger have therapeutic potential in age-related neurological disorders through by modulating cell death or cell survival signaling molecules.
Journal ArticleDOI
Protective properties of 6-gingerol-rich fraction from Zingiber officinale (Ginger) on chlorpyrifos-induced oxidative damage and inflammation in the brain, ovary and uterus of rats.
Amos O. Abolaji,Mercy Ojo,Tosin T. Afolabi,Mary D. Arowoogun,Darlinton Nwawolor,Ebenezer O. Farombi +5 more
TL;DR: Overall, the protective effects of 6-GRF on CPF-induced toxicity in the brain and reproductive organs of rats may be due to its potent antioxidative, anti-inflammatory and antiapoptotic properties.
References
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Journal ArticleDOI
Antioxidant actions of thymol, carvacrol, 6-gingerol, zingerone and hydroxytyrosol
Robert Aeschbach,J. Löliger,Brigitte C. Scott,A Murcia,John Butler,Barry Halliwell,Okezie I. Aruoma +6 more
TL;DR: The data suggest that thymol, carvacrol and 6-gingerol possess useful antioxidant properties and may become important in the search for 'natural' replacements for 'synthetic' antioxidant food additives.
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Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol.
Swarnalatha Dugasani,Mallikarjuna Rao Pichika,Vishna Devi Nadarajah,Madhu Katyayani Balijepalli,Satyanarayana Tandra,Jayaveera Narsimha Korlakunta +5 more
TL;DR: 6-Shogaol has exhibited the most potent antioxidant and anti-inflammatory properties which can be attributed to the presence of alpha,beta-unsaturated ketone moiety, and this study justifies the use of dry ginger in traditional systems of medicine.
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Analgesic and anti-inflammatory activities of [6]-gingerol
TL;DR: Results suggested that [6]-gingerol possessed analgesic and anti-inflammatory activities.
Journal ArticleDOI
Pharmacological studies on ginger. i. pharmacological actions of pungent constituents, (6)-gingerol and (6)-shogaol
TL;DR: General pharmacological studies were performed on ( 6)-gingerol and (6)-shogaol which are the pungent constituents of ginger which produced an inhibition of spontaneous motor activity, an antipyretic and analgesic effects, prolonged hexobarbital-induced sleeping time, and an intense antitussive effect in comparison with dihydrocodeine phosphate.
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[6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin.
Sue Ok Kim,Joydeb Kumar Kundu,Young Kee Shin,Jin Hong Park,Myung-Haing Cho,Tae-Yoon Kim,Young-Joon Surh +6 more
TL;DR: Topical application of [6]-gingerol inhibits TPA-induced COX-2 expression in mouse skin in vivo by blocking the p38 MAP kinase-NF-κB signaling pathway.