Journal ArticleDOI
Antiplatelet effects of a new de-N-acetyl-lyso-glycosphingolipid
Ezio Tubaro,Luisella Belogi,Carlo M. Croce,Giovanni Cavallo,Guiseppina Guida,Giorgio Borelli +5 more
TLDR
WILD20 antiplatelet effect is due to the interference with ADP or thrombin-induced aggregation, probably via phospholipase A2 (PLA2) blockade; the substance is also effective when arachidonic acid is used as an agonist.About:
This article is published in European Journal of Pharmacology: Environmental Toxicology and Pharmacology.The article was published on 1993-08-02. It has received 6 citations till now. The article focuses on the topics: Agonist & Phospholipase A2.read more
Citations
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Journal ArticleDOI
2-Deoxy-disaccharide approach to natural and unnatural glycosphingolipids synthesis
TL;DR: In this article, 2-Deoxydisaccharides were easily converted into glycosylphytosphingosines, as new and efficient precursors of natural and unnatural glycosphingolipids.
Journal ArticleDOI
Phospholipase A2 inhibitors in development.
U Tibes,W G Friebe +1 more
TL;DR: Indications for which PLA2 inhibitors are being pursued include, sepsis, acute pancreatitis, inflammatory skin and bowel diseases, asthma, and rheumatoid arthritis, and there are no likely clinical candidates emerging from the ranks of cPLA2 and iPLA2 inhibitors in development.
Journal ArticleDOI
Expression of the GM1-species, [NeuN]-GM1, in a case of human glioma.
TL;DR: NeuN GM1 is a glioma-associated ganglioside but its exceptional expression limits its relevance as a molecule involved in general tumor biology.
Journal ArticleDOI
Involvement of GD3 in platelet activation. A novel association with Fcgamma receptor.
Francesca Martini,Silvia Riondino,Pasquale Pignatelli,P. P. Gazzaniga,Patrizia Ferroni,Luisa Lenti +5 more
TL;DR: The results suggest that following platelet activation, GD3 is rapidly expressed on the platelet surface and internalised to the cytoskeleton where it transiently associates first with the Src family tyrosine kinase Lyn then with the Fc receptor gamma chain, which leads to an enhanced CD32 expression on the Platelet membrane.
Journal ArticleDOI
Inhibition of Human Platelet Aggregation by Gangliosides
TL;DR: Results indicate that the major pathway(s), but not all, driving to the aggregation process following the interaction of ligand-receptor may be blocked by pretreatment of human platelets with gangliosides.
References
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Journal ArticleDOI
Aggregation of blood platelets by adenosine diphosphate and its reversal.
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Ganglioside-mediated modulation of cell growth. Specific effects of GM3 and lyso-GM3 in tyrosine phosphorylation of the epidermal growth factor receptor.
TL;DR: It is possible that de-N-fatty acylation of gangliosides could be an effective means to modulate EGF receptor function in membranes.
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Adenosine diphosphate-induced platelet aggregation in suspensions of washed rabbit platelets.
TL;DR: On comparison with rabbit platelets prepared from blood taken into EDTA, the only differences observed were the much greater sensitivity to ADP and a higher calcium content; platelet morphology, nucleotide levels, and conversions of 14C‐ATP and 14C-ADP at the platelet membrane were similar.
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Disialogangliosides GD2 and GD3 are involved in the attachment of human melanoma and neuroblastoma cells to extracellular matrix proteins.
TL;DR: Control periodate oxidation of terminal, unsubstituted sialic acid residues on the cell surface not only specifically destroys the antigenic epitopes on GD2 and GD3 recognized by specific Mabs but also inhibits melanoma cell and neuroblastoma cell attachment.
Journal ArticleDOI
Uteroglobin inhibits phospholipase A2 activity.
TL;DR: It is speculated that progesterone may exert its antimotility effects on the uterus via uteroglobin which, by inhibiting PLA2, decreases arachidonic acid release and subsequently reduces prostaglandin levels in this organ.