Journal ArticleDOI
Antisense oligonucleotides: a new therapeutic principle
Eugen Uhlmann,Anusch Peyman +1 more
Reads0
Chats0
About:
This article is published in Chemical Reviews.The article was published on 1990-06-01. It has received 2224 citations till now. The article focuses on the topics: Antisense RNA.read more
Citations
More filters
Patent
Transgenic non-human animals capable of producing heterologous antibodies
Nils Lonberg,Robert M. Kay +1 more
TL;DR: In this paper, a transgenic non-human animals capable of producing heterologous antibodies and methods for producing human sequence antibodies which bind to human antigens with substantial affinity are described.
Patent
Transgenic non-human animals for producing heterologous antibodies
Nils Lonberg,Robert M. Kay +1 more
TL;DR: In this paper, a transgenes containing sequences of unrearranged heterologous human immunoglobulin heavy chains are introduced into a non-human animal, thereby forming a transgenic animal capable of functionally rearranging transgenio-globulin sequences and producing a repertoire of antibodies.
Patent
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
Nils Lonberg,Robert M. Kay +1 more
TL;DR: In this article, a transgenes containing sequences of unrearranged heterologous human immunoglobulin heavy chains are introduced into a non-human animal, thereby forming a transgenic animal capable of functionally rearranging transgenio-globulin sequences and producing a repertoire of antibodies.
Journal ArticleDOI
PNA hybridizes to complementary oligonucleotides obeying the Watson–Crick hydrogen-bonding rules
Michael Egholm,Ole Buchardt,Leif Christensen,Carsten Behrens,Susan M. Freier,David A. Driver,Rolf H. Berg,Seog K. Kim,Bengt Nordén,Peter E. Nielsen +9 more
TL;DR: It is reported here that PNA containing all four natural nucleobases hybridizes to complementary oligonucleotides obeying the WatsonCrick base-pairing rules, and thus is a true DNA mimic in terms of base- Pair recognition.
Journal ArticleDOI
Aptamers: An Emerging Class of Molecules That Rival Antibodies in Diagnostics
TL;DR: Aptamers are different from antibodies, yet they mimic properties of antibodies in a variety of diagnostic formats, and may play a key role either in conjunction with, or in place of, antibodies in the form of aptamer-based diagnostic products in the market.
Related Papers (5)
Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide
Antisense oligonucleotides as therapeutic agents--is the bullet really magical?
Cy A. Stein,Yung-Chi Cheng +1 more