Journal ArticleDOI
Antitumour effect of lymphoid cells activated by interferon.
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TLDR
Evidence is presented that syngeneic lymphoid cells may be similarly activated by interferon and that syNGeneicymphoid cells plusInterferon suppress the growth of tumour cells in vivo.Abstract:
INTERFERON induces a cytotoxic effect in normal mouse spleen cells against allogeneic tumour target cells in tissue culture1,2. We here present evidence that syngeneic lymphoid cells may be similarly activated by interferon and that syngeneic lymphoid cells plus interferon suppress the growth of tumour cells in vivo.read more
Citations
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Journal ArticleDOI
Anti-viral activity induced by culturing lymphocytes with tumor-derived or virus-transformed cells. Enhancement of human natural killer cell activity by interferon and antagonistic inhibition of susceptibility of target cells to lysis.
G Trinchieri,D Santoli +1 more
TL;DR: Cell separation experiments support the hypothesis that interferon enhances the activity of natural killer cells rather than generating a new population of effector cells, and might render the natural killer cell system an inducible selective defense mechanism against tumor and virus-infected cells.
Journal ArticleDOI
Anti-viral activity induced by culturing lymphocytes with tumor-derived or virus-transformed cells. Identification of the anti-viral activity as interferon and characterization of the human effector lymphocyte subpopulation.
TL;DR: The ability of certain cell lines to induce interferon seems to be preferentially associated with tumor origin or with in vitro transformation by certain viruses (Epstein-Barr virus, murine sarcoma virus).
Journal ArticleDOI
Do natural killer cells engage in regulated reactions against self to ensure homeostasis
TL;DR: It is proposed that the suppression of NK cytolysis demonstrated in vitro was a manifestation of regulatory mechanisms modulating the level of NK activity in vivo.
Book ChapterDOI
In Vitro Approaches to the Mechanism of Cell-Mediated Immune Reactions
TL;DR: This chapter focusses on the study of cell-mediated immunity in vitro, principally in terms of explaining the effector process of the response, with general assumptions that all cell- mediated immune reactions have a common basis.
References
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Journal ArticleDOI
Production of Malignancy in Vitro. IV. The Mouse Fibroblast Cultures and Changes Seen in the Living Cells
Wilton R. Earle,Edward L. Schilling,Thomas H. Stark,Nancy P. Straus,Mary F. Brown,Emma Shelton +5 more
Journal ArticleDOI
Inhibition of tumor growth by polyinosinic-polycytidylic acid
TL;DR: The synthetic double-stranded RNA, polyinosinic-cytidylic acid, inhibits the growth of some tumors in mice and results in decreased growth rates of the tumors and increased survival times of the animals.
Journal ArticleDOI
Interferon and the interaction of allogeneic normal and immune lymphocytes with L-cells
TL;DR: Nuclei of immune lymphocytes proved to exert the same destructive effect on target cells as that of intact immune lymphocyte2,3.
Journal ArticleDOI
Synthetic double-stranded RNA: inhibitory effect on murine leukaemia and sarcoma viruses in cell cultures.
TL;DR: The inhibitory effect of poly I : poly C on cellular transformation induced by MSV is confirmed, and the growth of Friend leukaemia virus in mouse embryo cells is described.