Journal ArticleDOI
Antiviral Activity of 3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol and its Derivatives Against Influenza A(H1N1)2009 Virus
O. V. Ardashov,Vladimir V. Zarubaev,Anna A. Shtro,Dina V. Korchagina,Konstantin P. Volcho,Nariman F. Salakhutdinov,Oleg I. Kiselev +6 more
TLDR
A number of new derivatives of monoterpenoid with a para-menthane framework 3-methyl-6-(prop-1-en-2- yl)cyclohex-3-ene-1,2-diol (-)-3 were synthesized and the absolute configuration of compound 6 was shown to be critical for its antiviral activity.Abstract:
A number of new derivatives of monoterpenoid with a para-menthane framework 3-methyl-6-(prop-1-en-2- yl)cyclohex-3-ene-1,2-diol (-)-3 were synthesized. The antiviral activity of (-)-3 and its derivatives against the pandemic influenza virus A/California/07/09 (H1N1)v was studied in vitro. Compound (-)-3 was found to be active against this vi- rus (selectivity index 7.5); for mononicotinate (+)-6 the selectivity index was 17. The absolute configuration of compound 6 was shown to be critical for its antiviral activity.read more
Citations
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Journal ArticleDOI
Discovery of a new class of antiviral compounds: camphor imine derivatives.
A. S. Sokolova,Olga I. Yarovaya,Olga I. Yarovaya,Andrey V. Shernyukov,Yuriy V. Gatilov,Yuliya V. Razumova,Vladimir V. Zarubaev,Tatiana S. Tretiak,Andrey G. Pokrovsky,Oleg I. Kiselev,Nariman F. Salakhutdinov +10 more
TL;DR: A new class of compounds featuring a camphor moiety that exhibits potent inhibitory activity against influenza A (H1N1)pdm09 and A(H5N1), and the most potent antiviral compound is imine 2 with therapeutic index more than 500.
Journal ArticleDOI
Monoterpenes as a renewable source of biologically active compounds
TL;DR: In this article, a review of various types of biological activity exhibited by monoterpenes and their derivatives, including analgesic, anti-inflammatory, anticonvulsant, antidepressant and anti-Alzheimer, antiParkinsonian, antiviral, and antibacterial (anti-tuberculosis) effects is presented.
Journal ArticleDOI
Highly Potent Activity of (1R,2R,6S)-3-Methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol in Animal Models of Parkinson’s Disease
O. V. Ardashov,Alla Pavlova,Irina V. Il'ina,Ekaterina A. Morozova,Dina V. Korchagina,Elena V. Karpova,Konstantin P. Volcho,Tatyana G. Tolstikova,Nariman F. Salakhutdinov +8 more
TL;DR: The use of compound 1 resulted in nearly full recovery of the locomotor and exploratory activities and was as effective as the comparator agent (levodopa) in both MPTP and haloperidol animal models.
Journal ArticleDOI
Camphor-based symmetric diimines as inhibitors of influenza virus reproduction
A. S. Sokolova,Olga I. Yarovaya,Olga I. Yarovaya,Dina V. Korchagina,Vladimir V. Zarubaev,Tatiana S. Tretiak,Pavel Anfimov,Oleg I. Kiselev,Nariman F. Salakhutdinov +8 more
TL;DR: Derivatives of camphor can be considered as prospective antiinfluenza compounds active against influenza viruses resistant to adamantane-based drugs.
Journal ArticleDOI
Anti-influenza activity of monoterpene-derived substituted hexahydro-2H-chromenes
Oksana S. Patrusheva,Vladimir V. Zarubaev,Anna A. Shtro,Yana R. Orshanskaya,Sergey A. Boldyrev,Irina V. Ilyina,Svetlana Yu. Kurbakova,Dina V. Korchagina,Konstantin P. Volcho,Nariman F. Salakhutdinov +9 more
TL;DR: Just compound 5i that contains a fluorine substituent exhibited more potent anti-influenza activity along with low cytotoxicity, and two new promising types of antiviral compounds were identified.
References
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Sabah A. A. Jassim,M. A. Naji +1 more
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Book ChapterDOI
Bioactivity of Essential Oils and Their Components
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Journal ArticleDOI
Reactions of Allyl Alcohols of the Pinane Series and of Their Epoxides in the Presence of Montmorillonite Clay
Irina V. Il'ina,Konstantin P. Volcho,Dina V. Korchagina,Vladimir A. Barkhash,Nariman F. Salakhutdinov +4 more
TL;DR: In this paper, the reactivity of allyl alcohols of the pinane series and of their epoxides in the presence of montmorillonite clay in intra-and intermolecular reactions was studied.