Journal ArticleDOI
Novel antiviral agents: a medicinal plant perspective
Sabah A. A. Jassim,M. A. Naji +1 more
TLDR
There are innumerable potentially useful medicinal plants and herbs waiting to be evaluated and exploited for therapeutic applications against genetically and functionally diverse viruses families such as Retroviridae, Hepadnaviridae and Herpesviridae.Abstract:
Several hundred plant and herb species that have potential as novel antiviral agents have been studied, with surprisingly little overlap. A wide variety of active phytochemicals, including the flavonoids, terpenoids, lignans, sulphides, polyphenolics, coumarins, saponins, furyl compounds, alkaloids, polyines, thiophenes, proteins and peptides have been identified. Some volatile essential oils of commonly used culinary herbs, spices and herbal teas have also exhibited a high level of antiviral activity. However, given the few classes of compounds investigated, most of the pharmacopoeia of compounds in medicinal plants with antiviral activity is still not known. Several of these phytochemicals have complementary and overlapping mechanisms of action, including antiviral effects by either inhibiting the formation of viral DNA or RNA or inhibiting the activity of viral reproduction. Assay methods to determine antiviral activity include multiple-arm trials, randomized crossover studies, and more compromised designs such as nonrandomized crossovers and pre- and post-treatment analyses. Methods are needed to link antiviral efficacy/potency- and laboratory-based research. Nevertheless, the relative success achieved recently using medicinal plant/herb extracts of various species that are capable of acting therapeutically in various viral infections has raised optimism about the future of phyto-antiviral agents. As this review illustrates, there are innumerable potentially useful medicinal plants and herbs waiting to be evaluated and exploited for therapeutic applications against genetically and functionally diverse viruses families such as Retroviridae, Hepadnaviridae and Herpesviridaeread more
Citations
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Journal ArticleDOI
Biological effects of essential oils - A review
TL;DR: Findings suggest that, at least in part, the encountered beneficial effects of essential oils are due to prooxidant effects on the cellular level.
Journal ArticleDOI
A review on antibacterial, antiviral, and antifungal activity of curcumin.
Soheil Zorofchian Moghadamtousi,Habsah Abdul Kadir,Pouya Hassandarvish,Hassan Tajik,Sazaly AbuBakar,Keivan Zandi +5 more
TL;DR: Previous antimicrobial studies of curcumin are summarized towards its application in the future studies as a natural antimicrobial agent.
Journal ArticleDOI
Bioavailability of Dietary Polyphenols and Gut Microbiota Metabolism: Antimicrobial Properties
TL;DR: This paper revises and discusses these antimicrobial activities of dietary polyphenols and their relevance for human health, shedding light on the importance of polyphenol structure recognition by specific enzymes produced by intestinal microbial taxa.
Journal ArticleDOI
Identification of natural compounds with antiviral activities against SARS-associated coronavirus
Shi You Li,Cong Chen,Haiqing Zhang,Hai Yan Guo,Hui Wang,Lin Wang,Lin Wang,Xiang Zhang,Shi Neng Hua,Jun Yu,Pei-Gen Xiao,Rongsong Li,Xuehai Tan +12 more
TL;DR: The results suggested that four herbal extracts and the compound lycorine are candidates for the development of new anti-SARS-CoV drugs in the treatment of SARS.
Journal ArticleDOI
Essential Oils of Aromatic Plants with Antibacterial, Antifungal, Antiviral, and Cytotoxic Properties – an Overview
TL;DR: Essential oils derived from aromatic medicinal plants have been reported to exhibit exceptionally good antimicrobial effects against bacteria, yeasts, filamentous fungi, and viruses.
References
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Journal ArticleDOI
Flavonoids, a class of natural products of high pharmacological potency
TL;DR: The few existing reports on the careful pharmacodynamic, pharmacokinetic and clinical studies which have been made have been summarized to provide a basis for a full-scale investigation of the therapeutic potential of flavonoids.
Book ChapterDOI
Effect of plant flavonoids on immune and inflammatory cell function
TL;DR: A considerable body of evidence suggests that plant flavonoids may be health-promoting, disease-preventing dietary compounds.
Journal ArticleDOI
A review of the plants of the genus Phyllanthus: their chemistry, pharmacology, and therapeutic potential.
TL;DR: Together this data strongly supports the view that the plants belonging to the genus Phyllanthus have potential beneficial therapeutic actions in the management of hepatitis B, nefrolitiase, and in painful disorders.
Journal ArticleDOI
A phase I trial of andrographolide in HIV positive patients and normal volunteers.
Carlo Calabrese,Sheryl H. Berman,John G. Babish,Xinfang Ma,Lynne Shinto,Melissa Dorr,Kameron Wells,Cynthia A. Wenner,Leanna J. Standish +8 more
TL;DR: Andrographolide may inhibit HIV‐induced cell cycle dysregulation, leading to a rise in CD4+ lymphocyte levels in HIV‐1 infected individuals, according to this phase I dose‐escalating clinical trial.
Journal ArticleDOI
Current lead natural products for the chemotherapy of human immunodeficiency virus (HIV) infection
TL;DR: A large variety of natural products have been described as anti-HIV agents, and for a portion thereof the target of interaction has been identified, and it is shown that L-c hicoric acid owes its anti-hIV activity to a specific interaction with the viral envelope gp120 rather than integrase.