Journal ArticleDOI
Antiviral Chinese medicinal herbs against respiratory syncytial virus.
Shuang-Cheng Ma,Jiang Du,Paul Pui-Hay But,Xue-Long Deng,Yong-Wen Zhang,Vincent E.C. Ooi,Hong-Xi Xu,Spencer H. S. Lee,Song Fong Lee +8 more
TLDR
Forty-four medicinal herbs were tested for antiviral activities against respiratory syncytial virus (RSV) by means of the cytopathologic effect (CPE) assay, and anagyrine, oxymatrine, sophoranol, wogonin, and oroxylin A were identified as the potent anti-RSV components.About:
This article is published in Journal of Ethnopharmacology.The article was published on 2002-02-01. It has received 256 citations till now. The article focuses on the topics: Scutellaria baicalensis & Sophora flavescens.read more
Citations
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New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin.
TL;DR: This review is aimed to summarize the research results obtained since the last 20 years and to highlight the recently discovered molecular mechanisms of Scutellaria baicalensis.
Journal ArticleDOI
Lonicera japonica Thunb.: ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine.
TL;DR: The ethnopharmacology, the biological activities, toxicology and phytochemistry of Lonicera japonica, a widely used traditional Chinese medicine, are reviewed to lead to the development of new drugs and therapeutics for various diseases.
Journal ArticleDOI
Small Molecules Blocking the Entry of Severe Acute Respiratory Syndrome Coronavirus into Host Cells
Ling Yi,Zhengquan Li,Kehu Yuan,Xiuxia Qu,Jian Chen,Guangwen Wang,Hong Zhang,Hongpeng Luo,Lili Zhu,Pengfei Jiang,Lirong Chen,Yan Shen,Min Luo,Guoying Zuo,Jianhe Hu,Deliang Duan,Yuchun Nie,Xuanling Shi,Wei Wang,Yang Han,Taisheng Li,Yuqing Liu,Mingxiao Ding,Hongkui Deng,Xiaojie Xu +24 more
TL;DR: Several small molecules were identified that can be used for developing new classes of anti-SARS-CoV drugs and is potentially useful for the high-throughput screening of drugs inhibiting the entry of HIV, hepatitis C virus, and other insidious viruses into their host cells.
Journal ArticleDOI
The genus Scutellaria an ethnopharmacological and phytochemical review
Xiaofei Shang,Xi-Rui He,He Xiaoying,Maoxing Li,Ru-Xue Zhang,Pengcheng Fan,Quanlong Zhang,Zhengping Jia +7 more
TL;DR: The present paper reviews the ethnopharmacology, the biological activities and the correlated chemical compounds of Scutellaria species, which includes about 350 species commonly known as skullcaps, and finds increasing data supports application and exploitation for new drug development.
Journal ArticleDOI
Antiviral activity of four types of bioflavonoid against dengue virus type-2
TL;DR: Results from the study suggest that only quercetin demonstrated significant anti-DENV-2 inhibitory activities and this group of flavonoids, flavonol, could be investigated further to discover the common mechanisms of inhibition of dengue virus replication.
References
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Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine
Hyun Wha Kim,Jose G. Canchola,Carl D. Brandt,Gloria Pyles,Robert M. Chanock,Keith E. Jensen,Robert H. Parrott +6 more
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Antibacterial, antifungal and antiviral activity of propolis of different geographic origin.
TL;DR: It seems that propolis has general pharmacological value as a natural mixture and not as a source of new powerful antimicrobial, antifungal and antiviral compounds.
Journal ArticleDOI
Respiratory syncytial viral infection in infants with congenital heart disease.
Noni E. MacDonald,Caroline B. Hall,Stephen C. Suffin,Chloe Alexson,Peter Harris,James Manning +5 more
TL;DR: Nine of the 11 infants (73 per cent) with congenital heart disease and pulmonary hypertension died during their RSV illness, and the infants with RSV infection had a higher mortality rate than the others.
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Field evaluation of a respiratory syncytial virus vaccine and a trivalent parainfluenza virus vaccine in a pediatric population
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Natural Product Drug Discovery and Development: New Perspectives on International Collaboration
Joe Baker,Robert P. Borris,Brad Carte,Geoffrey A. Cordell,Djaja D. Soejarto,Gordon M. Cragg,Mahabir P. Gupta,Maurice M. Iwu,Domingo R. Madulid,Varro E. Tyler +9 more
TL;DR: A discussion of policies for international collaboration and compensation being implemented by several developed country organizations, and the perspectives on the current developments given by representatives of some of the source countries located in the regions of greatest biodiversity.