Journal ArticleDOI
Aqueous Barbier-Grignard type reaction: Scope, mechanism, and synthetic applications
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This article is published in Tetrahedron.The article was published on 1996-04-15. It has received 421 citations till now. The article focuses on the topics: Barbier reaction & Scope (project management).read more
Citations
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Cross-dehydrogenative coupling (CDC): exploring C-C bond formations beyond functional group transformations.
TL;DR: This work over the past several years to form carbon-carbon bonds directly from two different C-H bonds under oxidative conditions, cross-dehydrogenative coupling (CDC) is described, which provides an alternative to the separate steps of prefunctionalization and defunctionsalization that have traditionally been part of synthetic design.
Journal ArticleDOI
Organic chemistry in water
TL;DR: Water has emerged as a versatile solvent for organic chemistry in recent years and gives completely new reactivity, including pericyclic reactions, reactions of carbanion equivalent, and reactions of carbocation equivalent.
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A highly efficient three-component coupling of aldehyde, alkyne, and amines via C-H activation catalyzed by gold in water
Chunmei Wei,Chao-Jun Li +1 more
TL;DR: A highly efficient three-component-coupling of aldehyde, alkyne, and amine (A3 Coupling) catalyzed by gold via C-H activation was developed in water and nearly quantitative yields of the corresponding propargylamines were obtained.
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Organic syntheses using indium-mediated and catalyzed reactions in aqueous media
Chao-Jun Li,Tak Hang Chan +1 more
TL;DR: Indium-Mediated Barbier-type reactions as discussed by the authors have been used for a variety of purposes, such as the synthesis of sialic acids and carbohydrate homologations.
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Samarium Diiodide Mediated Reactions in Total Synthesis
TL;DR: This Review highlights selected applications of SmI(2) in total synthesis, with special emphasis on novel transformations and mechanistic considerations.
References
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Journal ArticleDOI
Organic reactions in aqueous media - with a focus on carbon-carbon bond formation
TL;DR: In the last decade, there has been increasing recognition that organic reactions carried out in aqueous media may offer advantages over those occurring in organic solvents as discussed by the authors, which is the essence of organic synthesis.
Book
Modern Synthetic Reactions
TL;DR: The Modern Synthetic Reactions as discussed by the authors is a book about modern organic synthesis with a focus on the use of continuous flow reactors, which is a tool for the modern synthesis of organic compounds.
Journal ArticleDOI
Water-Soluble Ligands, Metal Complexes, and Catalysts: Synergism of Homogeneous and Heterogeneous Catalysis
TL;DR: Water-soluble catalysts as mentioned in this paper combine the advantages of homogeneous and heterogeneous catalysis: simple and complete separation of the product from the catalyst, high activity, and high selectivity.
Journal ArticleDOI
Water-Promoted Organic Reactions
TL;DR: The reactions reviewed in this article are those that show an unusual outcome when performed in water or in an aqueous medium, except when they are clearly due to the polarity as for example in nucleophilic substitution reactions.
Related Papers (5)
Organic syntheses using indium-mediated and catalyzed reactions in aqueous media
Chao-Jun Li,Tak Hang Chan +1 more