Journal ArticleDOI
Aromatase inhibitors for the treatment of endometriosis: a systematic review about efficacy, safety and early clinical development.
Simone Garzon,Antonio Simone Laganà,Fabio Barra,Jvan Casarin,Antonella Cromi,Ricciarda Raffaelli,Stefano Uccella,Massimo Franchi,Fabio Ghezzi,Simone Ferrero +9 more
TLDR
Based on the critical role of estrogens and the rate-limiting step in the production of the estrogens represented by the aromatase enzyme, AIs are a potential therapeutic option for women affected by endometriosis, but further research is needed to clarify the efficacy and safety of AIs.Abstract:
Pharmacotherapy has a key role in endometriosis treatment and management, however, a significant proportion of patients have only intermittent or limited benefits with current treatment options. Th...read more
Citations
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Linzagolix: a new GnRH-antagonist under investigation for the treatment of endometriosis and uterine myomas.
Susan Dababou,Simone Garzon,Antonio Simone Laganà,Simone Ferrero,Giulio Evangelisti,Marco Noventa,Maurizio Nicola D'Alterio,Stefano Palomba,Stefano Uccella,Massimo Franchi,Fabio Barra +10 more
TL;DR: Uterine myomas and endometriosis are benign hormone dependent diseases affecting women of reproductive age as mentioned in this paper, and substantial efforts have been made to develop innovative medical options for treating the...
Journal ArticleDOI
Clinico-pathological assessment of surgically removed abdominal wall endometriomas following cesarean section.
Abdulkarim Hasan,Abdou Deyab,Khaled Monazea,Abdoh Salem,Zahraa Futooh,Mahmoud A. Mostafa,Ahmed Youssef,Mohamed S M Nasr,Nasser Omar,Ali A. Rabaan,Doha Maher Taie +10 more
TL;DR: Patients with suspected AWE should undergo preoperative cytological biopsy to exclude alternative diagnosis and wide surgical excision with margin of less than 1 cm could be accepted especially in case of weak abdominal wall.
Journal ArticleDOI
CTLA4-Linked Autoimmunity in the Pathogenesis of Endometriosis and Related Infertility: A Systematic Review
Mislav Mikuš,Marina Šprem Goldštajn,Ivan Brlečić,Stipe Dumančić,Antonio Simone Laganà,Vito Chiantera,Goran Vujić,Mario Ćorić +7 more
TL;DR: Evidence from clinical studies shows that CTLA4-based autoimmunity is involved in the maintenance of chronic inflammation in the peritoneal environment, with pre-clinical evidence of anti-CTLA antibodies as a potential novel target therapy for endometriosis.
Journal ArticleDOI
Uterine leiomyoma is associated with the risk of developing endometriosis: A nationwide cohort study involving 156,195 women.
TL;DR: In this article, a large nationwide sample with 14 years of data was collected from Taiwan's Longitudinal Health Insurance Database 2000 (LHID2000), where 31,239 women aged ≥20 years diagnosed with leiomyoma were matched with 124,956 controls (1:4) by 5-year age groups and year of diagnosis.
Journal ArticleDOI
LigAdvisor: a versatile and user-friendly web-platform for drug design.
TL;DR: LigAdvisor as discussed by the authors integrates information reported in DrugBank, Protein Data Bank, UniProt, Clinical Trials and Therapeutic Target Database into an intuitive platform, to facilitate drug discovery tasks such as drug repurposing, polypharmacology, target fishing and profiling.
References
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Journal ArticleDOI
Proteomic analysis of peritoneal fluid in women with endometriosis.
Simone Ferrero,David J. Gillott,Valentino Remorgida,Paola Anserini,Kit Yi Leung,Nicola Ragni,J. G. Grudzinskas +6 more
TL;DR: Evaluating differences in the expression of proteins present in the peritoneal fluid of women with and without endometriosis found several molecules had aberrant expression, useful for a better understanding of the pathogenesis of this disease.
Journal ArticleDOI
Current understanding on pharmacokinetics, clinical efficacy and safety of progestins for treating pain associated to endometriosis
TL;DR: This review aims to offer the reader a complete overview of pharmacokinetic (PK) and clinical efficacy of progestins for the treatment of endometriosis.
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Clinical dynamics of Dienogest for the treatment of endometriosis: from bench to bedside.
Antonio Simone Laganà,Salvatore Giovanni Vitale,Roberta Granese,Vittorio Palmara,Helena Ban Frangež,Eda Vrtačnik-Bokal,Benito Chiofalo,Onofrio Triolo +7 more
TL;DR: Progestins (synthetic progestational agents) are used in the management of symptomatic endometriosis both as first-line therapy and after surgery, and progestins are usually well tolerated and offer similar efficacy for the treatment of endometiosis-related CPP and prevention of recurrence with respect to other drugs.
Journal ArticleDOI
Safety of medical treatments for endometriosis
TL;DR: Treatment of endometriosis with progestins may be feasible in women with metabolic or cardiovascular contraindications to estroprogestin and the annual cost of therapy compares favorably with other available medications.
Journal ArticleDOI
Changes in the size of rectovaginal endometriotic nodules infiltrating the rectum during hormonal therapies
Simone Ferrero,Umberto Leone Roberti Maggiore,Carolina Scala,Martina Di Luca,Pier Luigi Venturini,Valentino Remorgida +5 more
TL;DR: 12-month administration of hormonal therapies reduces the volume of rectovaginal endometriotic nodules infiltrating the rectum in the majority of cases.