Journal ArticleDOI
Aromatase inhibitors for the treatment of endometriosis: a systematic review about efficacy, safety and early clinical development.
Simone Garzon,Antonio Simone Laganà,Fabio Barra,Jvan Casarin,Antonella Cromi,Ricciarda Raffaelli,Stefano Uccella,Massimo Franchi,Fabio Ghezzi,Simone Ferrero +9 more
TLDR
Based on the critical role of estrogens and the rate-limiting step in the production of the estrogens represented by the aromatase enzyme, AIs are a potential therapeutic option for women affected by endometriosis, but further research is needed to clarify the efficacy and safety of AIs.Abstract:
Pharmacotherapy has a key role in endometriosis treatment and management, however, a significant proportion of patients have only intermittent or limited benefits with current treatment options. Th...read more
Citations
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D-Chiro-inositol and PCOS: between myth and reality. The never-ending story
TL;DR: The aim of this review is to clarify the use of inositols for the treatment of PCOS and the recent scientific theories about D-Chiro-Inositol properties as an ovarian aromatase inhibitor.
Journal ArticleDOI
Altered Endometrial Expression of α-Inhibin Subunit and Its Co-Receptor Betaglycan in Infertile Women with Endometriosis
Cynthia Dela Cruz,Q. T. Vilamil,Maíra Casalechi,Carolina P. Rezende,Wiviane A. Assis,Helen L. Del Puerto,Mauricio Simões Abrão,Fernando M. Reis +7 more
TL;DR: The findings suggest an abnormally increased expression of α-inhibin mRNA (not protein) and betaglycan (mRNA and protein) in the secretory-phase endometrium of women with endometriosis.
Journal ArticleDOI
A Systematic Review of Systematic Reviews on the Use of Aromatase Inhibitors for the Treatment of Endometriosis: The Evidence to Date
Panagiotis Peitsidis,Panagiotis Tsiakaras,Antonio Simone Laganà,Alexandros Laios,Ioannis D. Gkegkes,Christos Iavazzo +5 more
TL;DR: A systematic review of systematic reviews and narrative reviews on the use of aromatase inhibitors in the medical management of endometriosis was performed in this paper , which yielded initially 12,106 studies from different databases.
Journal ArticleDOI
The Search for Biomarkers in Endometriosis: a Long and Windy Road.
Milena Králíčková,Vaclav Vetvicka,Luděk Fiala,Antonio Simone Laganà,Simone Garzon,Simone Garzon +5 more
TL;DR: In this article, the authors summarize the most significant and novel results about biomarkers for the diagnosis and follow-up of women affected by endometriosis and present a comprehensive review.
References
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Journal ArticleDOI
ESHRE guideline: management of women with endometriosis
Gerard A.J. Dunselman,Nathalie Vermeulen,Christian M. Becker,Carlos Calhaz-Jorge,B. De Bie,O. Heikinheimo,L. Kiesel,Annemiek W. Nap,Andrew M. Prentice,Ertan Saridogan,David Soriano,Willianne L.D.M. Nelen +11 more
TL;DR: This guideline was produced by a group of experts in the field using the structured methodology of the Manual for ESHRE Guideline Development, including a thorough systematic search of the literature, quality assessment of the included papers up to January 2012 and consensus within the guideline group on all recommendations.
Journal ArticleDOI
3rd ESO-ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 3)
Fatima Cardoso,Ana Costa,Elżbieta Senkus,Matti Aapro,Fabrice Andre,Carlos H. Barrios,Jonas Bergh,G. Bhattacharyya,Laura Biganzoli,Maria João Cardoso,Lisa A. Carey,D. Corneliussen-James,Giuseppe Curigliano,Véronique Diéras,N.S. El Saghir,Alex Eniu,Lesley Fallowfield,D. Fenech,Prudence A. Francis,Karen A. Gelmon,Alessandra Gennari,Nadia Harbeck,Clifford A. Hudis,Bella Kaufman,Ian E. Krop,Musa Mayer,H. Meijer,Shirley Mertz,S. Ohno,Olivia Pagani,E. Papadopoulos,Fedro A. Peccatori,Frédérique Penault-Llorca,Martine Piccart,Jean-Yves Pierga,Hope S. Rugo,Lillie D. Shockney,George W. Sledge,Sandra M Swain,Christoph Thomssen,Andrew Tutt,Daniel A. Vorobiof,Binghe Xu,Larry Norton,Eric P. Winer +44 more
TL;DR: This ESO-ESMO ABC 5 Clinical Practice Guideline provides key recommendations for managing advanced breast cancer patients, and provides updates on managing patients with all breast cancer subtypes, LABC, follow-up, palliative and supportive care.
Journal ArticleDOI
Clinical practice. endometriosis
TL;DR: A healthy 25-year-old woman presents with worsening dysmenorrhea, pain of recent onset in the left lower quadrant, and dyspareunia.
Journal ArticleDOI
Aromatase inhibitors versus tamoxifen in early breast cancer: patient-level meta-analysis of the randomised trials
TL;DR: Recurrence RRs favoured aromatase inhibitors during periods when treatments differed, but not significantly thereafter, and 10-year breast cancer mortality was lower with switching to arom atase inhibitors than with remaining on tamoxifen, and there were fewer recurrences in these trials.
Journal ArticleDOI
Estrogen receptors alpha and beta form heterodimers on DNA.
TL;DR: It is shown that ERα and ERβ, expressed both in vitro and in vivo, form heterodimers which bind to DNA with an affinity similar to that of ER α and greater than that ofERβ homodimer.