CTLA4-Linked Autoimmunity in the Pathogenesis of Endometriosis and Related Infertility: A Systematic Review
Mislav Mikuš,Marina Šprem Goldštajn,Ivan Brlečić,Stipe Dumančić,Antonio Simone Laganà,Vito Chiantera,Goran Vujić,Mario Ćorić +7 more
TLDR
Evidence from clinical studies shows that CTLA4-based autoimmunity is involved in the maintenance of chronic inflammation in the peritoneal environment, with pre-clinical evidence of anti-CTLA antibodies as a potential novel target therapy for endometriosis.Abstract:
Several studies, although with conflicting results, have sought to determine the concentration of soluble CTLA4 antigens in peripheral blood plasma and peritoneal fluid in patients with endometriosis-related infertility. A systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) through a search of the following databases: MEDLINE, EMBASE, Global Health, The Cochrane Library, Health Technology Assessment Database and Web of Science, and Clinical Trials research register. We included observational or prospective human and animal studies with any features related to endometriosis and/or infertility studies involving CTLA4-related pathogenesis published in English. The results of studies in which the size and characteristics of the observed groups were not stated were excluded. From the initial pool of 73 publications identified and screened, we finally included 5 articles to summarize the most recent knowledge about CTLA4-linked autoimmunity in the pathogenesis of endometriosis and related infertility. Evidence from clinical studies shows that CTLA4-based autoimmunity is involved in the maintenance of chronic inflammation in the peritoneal environment, with pre-clinical evidence of anti-CTLA antibodies as a potential novel target therapy for endometriosis. However, CTLA4 gene analyses do not support findings of CTLA4-linked autoimmunity as a primary determinant of the pathogenesis of endometriosis. These findings underlie the role of complex interactions within the family of immune checkpoint molecules involved. Further studies are needed to investigate the clinical relevance of anti-CTLA target therapy, taking into account the potential adverse events and repercussions of novel immunologic therapy modalities. However, with the general scarcity of studies investigating this topic, the clinical importance of CTLA4 autoimmunity still remains unclear.read more
Citations
More filters
Journal ArticleDOI
The Risk of Endometrial Cancer and Uterine Sarcoma Following Endometriosis or Pelvic Inflammatory Disease
TL;DR: In this paper , the risk of uterine cancer in patients with endometriosis or pelvic inflammatory disease (PID) was determined in a population-based cohort study, where a total of 135,236 females with either PID and endometria, as well as 135, 236 age-matched controls were included.
Journal ArticleDOI
Nociceptin/Orphanin FQ Opioid Peptide-Receptor Expression in the Endometriosis-Associated Nerve Fibers—Possible Treatment Option?
TL;DR: In this paper , Nociceptin/orphanin FQ peptide (NOP) receptor expression was analyzed in EM-associated nerve fibers (NFs) for the first time.
Journal ArticleDOI
Investigation of the Changes in Concentrations of Vitamin D-Binding Protein and Lactoferin in Plasma and Peritoneal Fluid of Patients with Endometriosis
Barbara Lisowska-Myjak,Ewa Skarżyńska,Monika Wróbel,Grzegorz Mańka,Mariusz Kiecka,M. Lipa,Damian Warzecha,Robert Z. Spaczynski,P. Piekarski,Beata Banaszewska,Artur J Jakimiuk,Tadeusz Issat,Wojciech Rokita,Jakub Mlodawski,Maria Szubert,Piotr Sieroszewski,Grzegorz Raba,Kamil Szczupak,Tomasz Kluz,Marek Kluza,Miroslaw Wielgos,Piotr Laudanski +21 more
TL;DR: In this paper , the concentrations of vitamin D-binding protein and lactoferrin in the plasma and peritoneal fluid may facilitate the elucidation of molecular mechanisms in endometriosis.
Journal ArticleDOI
Inflammatory Markers in Women with Infertility: A Cross-Sectional Study
TL;DR: In this article , a cross-sectional study included 1028 infertile patients who were hospitalized at Jining Medical University between January 2016 and December 2022 to evaluate the independent relationships between each inflammatory marker in women with infertility.
Journal ArticleDOI
Amniotic fluid-derived exosomes attenuated fibrotic changes in POI rats through modulation of the TGF-β/Smads signaling pathway
Nahideh Nazdikbin Yamchi,Shahin Ahmadian,Halimeh Mobarak,Farhad Amjadi,Rahim Beheshti,Amin Tamadon,Reza Rahbarghazi,Mahdi Mahdipour +7 more
TL;DR: In this paper , the regenerative effects of amniotic fluid exosomes (AF-Exos) in a rat model for premature ovarian insufficiency (POI) were investigated.
References
More filters
Journal ArticleDOI
Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy
TL;DR: This work discusses biomarkers for anti-PD1 therapy based on immunological, genetic and virological criteria and suggests mechanism-based insights from such studies may guide the design of synergistic treatment combinations based on immune checkpoint blockade.
Journal ArticleDOI
The PRISMA 2020 statement: An updated guideline for reporting systematic reviews.
Matthew J. Page,Joanne E. McKenzie,Patrick M.M. Bossuyt,Isabelle Boutron,Tammy Hoffmann,Cynthia D. Mulrow,Larissa Shamseer,Jennifer Tetzlaff,Elie A. Akl,Sue E. Brennan,Roger Chou,Julie Glanville,Jeremy M. Grimshaw,Asbjørn Hróbjartsson,Manoj M. Lalu,Tianjing Li,Elizabeth Loder,Evan Mayo-Wilson,Steve McDonald,Luke A McGuinness,Lesley A. Stewart,James Thomas,Andrea C. Tricco,Vivian Welch,Penny Whiting,David Moher +25 more
TL;DR: The PRISMA 2020, an updated reporting guideline for systematic reviews and meta-analyses, was proposed by Page and colleagues as discussed by the authors, who describe the guidelines as "an updated reporting guidelines for systematic review and meta analysis".
Journal ArticleDOI
Rethinking mechanisms, diagnosis and management of endometriosis
TL;DR: A patient-centred, individualized, multi-modal and interdisciplinary integrated approach should be taken to maximize the quality of the patient’s ‘endometriosis life’ and how health-care professionals could rethink endometRIosis diagnosis and management is highlighted.
Journal ArticleDOI
CTLA4 gene polymorphism and autoimmunity
TL;DR: This review discusses recent progress in relating CTLA4 polymorphisms to disease susceptibility and considers the putative mechanisms by whichCTLA4 may act to inhibit autoimmunity.
Journal ArticleDOI
Endometriosis is a chronic systemic disease: clinical challenges and novel innovations
TL;DR: Endometriosis is classically defined as a chronic, gynaecological disease characterised by endometrial-like tissue present outside of the uterus and is thought to arise by retrograde menstruation as discussed by the authors.