Journal ArticleDOI
Aromatase inhibitors for the treatment of endometriosis: a systematic review about efficacy, safety and early clinical development.
Simone Garzon,Antonio Simone Laganà,Fabio Barra,Jvan Casarin,Antonella Cromi,Ricciarda Raffaelli,Stefano Uccella,Massimo Franchi,Fabio Ghezzi,Simone Ferrero +9 more
TLDR
Based on the critical role of estrogens and the rate-limiting step in the production of the estrogens represented by the aromatase enzyme, AIs are a potential therapeutic option for women affected by endometriosis, but further research is needed to clarify the efficacy and safety of AIs.Abstract:
Pharmacotherapy has a key role in endometriosis treatment and management, however, a significant proportion of patients have only intermittent or limited benefits with current treatment options. Th...read more
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Linzagolix: a new GnRH-antagonist under investigation for the treatment of endometriosis and uterine myomas.
Susan Dababou,Simone Garzon,Antonio Simone Laganà,Simone Ferrero,Giulio Evangelisti,Marco Noventa,Maurizio Nicola D'Alterio,Stefano Palomba,Stefano Uccella,Massimo Franchi,Fabio Barra +10 more
TL;DR: Uterine myomas and endometriosis are benign hormone dependent diseases affecting women of reproductive age as mentioned in this paper, and substantial efforts have been made to develop innovative medical options for treating the...
Journal ArticleDOI
Clinico-pathological assessment of surgically removed abdominal wall endometriomas following cesarean section.
Abdulkarim Hasan,Abdou Deyab,Khaled Monazea,Abdoh Salem,Zahraa Futooh,Mahmoud A. Mostafa,Ahmed Youssef,Mohamed S M Nasr,Nasser Omar,Ali A. Rabaan,Doha Maher Taie +10 more
TL;DR: Patients with suspected AWE should undergo preoperative cytological biopsy to exclude alternative diagnosis and wide surgical excision with margin of less than 1 cm could be accepted especially in case of weak abdominal wall.
Journal ArticleDOI
CTLA4-Linked Autoimmunity in the Pathogenesis of Endometriosis and Related Infertility: A Systematic Review
Mislav Mikuš,Marina Šprem Goldštajn,Ivan Brlečić,Stipe Dumančić,Antonio Simone Laganà,Vito Chiantera,Goran Vujić,Mario Ćorić +7 more
TL;DR: Evidence from clinical studies shows that CTLA4-based autoimmunity is involved in the maintenance of chronic inflammation in the peritoneal environment, with pre-clinical evidence of anti-CTLA antibodies as a potential novel target therapy for endometriosis.
Journal ArticleDOI
Uterine leiomyoma is associated with the risk of developing endometriosis: A nationwide cohort study involving 156,195 women.
TL;DR: In this article, a large nationwide sample with 14 years of data was collected from Taiwan's Longitudinal Health Insurance Database 2000 (LHID2000), where 31,239 women aged ≥20 years diagnosed with leiomyoma were matched with 124,956 controls (1:4) by 5-year age groups and year of diagnosis.
Journal ArticleDOI
LigAdvisor: a versatile and user-friendly web-platform for drug design.
TL;DR: LigAdvisor as discussed by the authors integrates information reported in DrugBank, Protein Data Bank, UniProt, Clinical Trials and Therapeutic Target Database into an intuitive platform, to facilitate drug discovery tasks such as drug repurposing, polypharmacology, target fishing and profiling.
References
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Journal Article
Laparoscopic surgery in endometriosis.
G H Eltabbakh,N A Bower +1 more
TL;DR: Robotic-assisted laparoscopic surgery promises to provide advantages in the management of women with severe endometriosis secondary to 3-dimensional visualization, decreasing surgeon's fatigue and hand tremors and improving surgical precision.
Journal ArticleDOI
Progestagens and anti-progestagens for pain associated with endometriosis.
TL;DR: There is only limited evidence to support the use of progestagens and anti-progestagens for pain associated with endometriosis.
Journal ArticleDOI
Treatment of symptomatic rectovaginal endometriosis with an estrogen–progestogen combination versus low-dose norethindrone acetate
Paolo Vercellini,Giuliana Pietropaolo,Olga De Giorgi,Roberta Pasin,A. Chiodini,Pier Giorgio Crosignani +5 more
TL;DR: Low-dose norethindrone acetate could be considered an effective, tolerable, and inexpensive first-choice medical alternative to repeat surgery for treating symptomatic rectovaginal endometriotic lesions in patients who do not seek conception.
Journal Article
The epidemiology of endometriosis.
M B Goldman,D W Cramer +1 more
TL;DR: The authors briefly describe the primary pathogenic hypotheses, discuss methodologic issues specific to endometriosis, and offer a brief interpretation of these findings and suggest hypotheses for future research.
Journal ArticleDOI
Unus pro omnibus, omnes pro uno: A novel, evidence-based, unifying theory for the pathogenesis of endometriosis.
Antonio Simone Laganà,Salvatore Giovanni Vitale,Francesca Maria Salmeri,Onofrio Triolo,Helena Ban Frangež,Eda Vrtačnik-Bokal,Lily Stojanovska,Vasso Apostolopoulos,Roberta Granese,Vincenza Sofo +9 more
TL;DR: A hypothesis is presented that deregulation of genes and the Wnt signaling pathway Wnt/β-catenin leads to aberrations and deregulation within the mesoderm, thus, may cause aberrant placement of stem cells.