Journal ArticleDOI
Aromatization of androgens by human breast cancer
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TLDR
Tumors which are capable of transforming dehydroepiandrosterone to estrogens were also able to aromatize testosterone suggesting that the presence of the aromatase enzyme is inherent to certain tumor cells.About:
This article is published in Steroids.The article was published on 1979-02-01. It has received 139 citations till now. The article focuses on the topics: Dehydroepiandrosterone & Estrogen.read more
Citations
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History of Aromatase: Saga of an Important Biological Mediator and Therapeutic Target
TL;DR: The saga of these studies of aromatase and the ultimate utilization of inhibitors as highly effective treatments of breast cancer and for use in reproductive disorders serves as the basis for this first Endocrine Reviews history manuscript.
Journal ArticleDOI
The importance of local synthesis of estrogen within the breast.
W.R. Miller,J. O'Neill +1 more
TL;DR: Assays of aromatase in adipose tissue from the different quadrants of mastectomy specimens from patients with breast cancer indicate that activity was always higher in quadrants associated with tumor as compared with non-involved quadrants, emphasizing the importance of local estrogen synthesis within the breast.
Journal ArticleDOI
Comparison of estrogen concentrations, estrone sulfatase and aromatase activities in normal, and in cancerous, human breast tissues.
TL;DR: The values of E(1)S and E(2) were significantly higher in the tumor tissue than in the area considered as normal, and the sulfatase activity was much higher than aromatase (130-200).
Journal ArticleDOI
Aromatase, 17β-hydroxysteroid dehydrogenase and intratissular sex hormone concentrations in cancerous and normal glandular breast tissue in postmenopausal women
TL;DR: DHEA(S) may constitute a mechanism by which these androgens stimulate cancer growth and a rationale (besides suppression of estrogen precursors) for medical or surgical adrenalectomy in hormone sensitive metastatic mammary cancer.
Journal ArticleDOI
The selective estrogen enzyme modulators in breast cancer: a review.
TL;DR: Quantitative evaluation indicates that in human breast tumor E(1)S 'via sulfatase' is a much more likely precursor for E(2) than is androgens 'via aromatase, which will provide a new possibility in the treatment of this disease.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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Source of Estrogen Production in Postmenopausal Women
TL;DR: The purpose of the present study was to investigate the mechanisms by which estrogen production arises in the human female following the menopause, and the results suggest an increase in conversion of A to E1 with age.
Journal ArticleDOI
Aromatization of androgens by muscle and adipose tissue in vivo.
TL;DR: In seven men the mean +/- SE value for the fractional conversion of androstene tissue was 0.0007 +/-0.0001 for muscle and 0.0012 +/- 0.0002 for adipose tissue, both of these values were significantly less than the respective values of and Frostenedione aromatization to estrone.
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Aromatization of androgens by human abdominal and breast fat tissue.
A. Nimrod,Kenneth J. Ryan +1 more
TL;DR: The results indicate a possible role of adipose tissue as a significant extra-gonadal source of estrogens in human abdominal, breast and axillary fat and testosterone was found to be aromatized as actively as androstenedione.
Journal Article
An Improved Assay for Nuclear Estrogen Receptor in Experimental and Human Breast Cancer
TL;DR: It is found that tumor biopsies may contain cytoplasmic receptor alone or may also have appreciable nuclear receptor, and the possibility that unoccupied receptor might be able to stimulate cell replication in these cases, even in the absence of estrogen.