Journal ArticleDOI
Array detection for speckle reduction in optical coherence microscopy
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TLDR
A spatial-diversity method for speckle suppression in optical coherence microscopy based on combining interference signals from an array of detectors placed in the back focal plane of the objective lens, such that elements receive light backscattered from the sample volume at different angles is introduced.Abstract:
This paper introduces a spatial-diversity method for speckle suppression in optical coherence microscopy. The method is based on combining interference signals from an array of detectors placed in the back focal plane of the objective lens, such that elements receive light backscattered from the sample volume at different angles. Incoherently adding ('compounding') the signals increases the signal-to-noise ratio of the processed image compared to that attainable with a single detector. The speckle-reduction method was demonstrated with a benchtop microscope equipped with a quadrant photodiode. To evaluate its potential application in dermatology, images of living skin acquired with and without compounding were compared. The quality of the compounded images was found to be substantially better. A signal-to-noise gain close to a factor of two (the theoretical maximum attainable using four detectors) was achieved without a significant loss in resolution. The method can be applied to arrays with a larger number of elements, potentially enabling more advanced forms of spatial-diversity and adaptive-optics methods.read more
Citations
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Optical coherence tomography - principles and applications
TL;DR: OCT as discussed by the authors synthesises cross-sectional images from a series of laterally adjacent depth-scans, which can be used to assess tissue and cell function and morphology in situ.
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Optical coherence tomography (OCT): a review
TL;DR: The state of the art of optical coherence tomography (OCT), an interferometric imaging technique that provides cross-sectional views of the subsurface microstructure of biological tissue is reviewed.
Journal ArticleDOI
Speckle in Optical Coherence Tomography
TL;DR: Four speckle-reduction methods-polarization diversity, spatialcompounding, frequency compounding, and digital signal processing-are discussed and the potential effectiveness of each method is analyzed briefly with the aid of examples.
Journal ArticleDOI
Review of polarization sensitive optical coherence tomography and Stokes vector determination.
TL;DR: The theory and calculation of the Stokes vector of light reflected from turbid media is described, application of PS-OCT to contemporary biomedical imaging problems is given and effect of multiple scattering and speckle on the accuracy and noise of the computed Stokes parameters is discussed.
Journal ArticleDOI
Ultrahigh-resolution full-field optical coherence tomography
TL;DR: A white-light interference microscope for ultrahigh-resolution full-field optical coherence tomography of biological media and subcellular-level images of plant, animal, and human tissues are presented.
References
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Journal ArticleDOI
Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TL;DR: OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.
Book ChapterDOI
Optical Coherence Tomography
Eric A. Swanson,J. Izatt,M. Bee,David Huang,Charles P. Lin,Carmen A. Puliafito,Carmen A. Puliafito,James G. Fujimoto +7 more
TL;DR: Optical coherence tomography (OCT) has developed rapidly since its first realisation in medicine and is currently an emerging technology in the diagnosis of skin disease as mentioned in this paper, where OCT is an interferometric technique that detects reflected and backscattered light from tissue.
Journal ArticleDOI
Some fundamental properties of speckle
TL;DR: In this paper, the distribution of scale sizes in a speckle pattern (i.e., the Wiener spectrum) is investigated from a physical point of view, and it is shown that adding M uncorrelated speckles on an intensity basis can reduce the contrast by 1/√M.
Journal ArticleDOI
Speckle in ultrasound B-mode scans
TL;DR: In this paper, the reduction in speckle that can be obtained with a compound scan with maximum amplitude writing is computed and the condition for the independence of two amplitude values is derived.
Journal ArticleDOI
Optical coherence microscopy in scattering media.
TL;DR: In this article, a novel technique, based on optical coherence tomography, was described for enhanced optical sectioning in confocal microscopy, which was demonstrated and compared with the predictions of a single-backscatter theory.
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